SLC17A1 Antibody

1. A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level. PMID: 27899376
2. I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans. PMID: 27906618
3. Data suggest that single nucleotide polymorphisms (SNPs) of solute carrier family 17 member 1 (SLC17A1) are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men. PMID: 26524967
4. Data suggest that single nucleotide polymorphisms (SNPs) rs9467596 and rs2096386 of the solute carrier family 17 (sodium phosphate), member 1 protein (SLC17A1) gene may have a correlation between hyperuricemia and alcohol drinking among Uygur patients. PMID: 26663070
5. Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males. PMID: 26290326
6. NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. PMID: 25252215
7. NPT1 is responsible for urate excretion under physiological conditions and its impairment is linked with the occurrence of gout. [review] PMID: 23876149
8. We observed a clear effect of SLC17A1 genotype on fructose load in Europeans but not Polynesian subgroups. PMID: 23852697
9. Renal urate transporter SLC17A1 is the third locus associated with gout at a genome-wide level of significance. PMID: 22541845
10. results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions PMID: 20566650
11. data suggest that SLC17A1 polymorphisms are associated with the development of gout. PMID: 19556210
12. structure and promoter activity, molecular cloning PMID: 11704559

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HGNC: 10929

OMIM: 182308

KEGG: hsa:6568

STRING: 9606.ENSP00000244527

UniGene: Hs.205816