Purity
Greater than 90% as determined by SDS-PAGE.
Research Area
Neuroscience
Alternative Names
Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK-1 receptor; NK-1R; NK1 receptor; NK1R; NK1R_HUMAN; NKIR; SPR; Substance P receptor; Substance-P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor (substance P receptor neurokinin 1 receptor); Tachykinin receptor 1 (substance P receptor neurokinin 1 receptor); Tachykinin receptor 1; TACR1
Species
Homo sapiens (Human)
Target Protein Sequence
MDNVLPVDSDLSPNISTNTSEPNQFVQPA
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Tag Info
N-terminal GST-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the
glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer,
6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
Amino acids 1-29 form the expressed segment for recombinant Human TACR1. The theoretical molecular weight of the TACR1 protein is 30.1 kDa. Expression of this TACR1 protein is conducted in e.coli. The TACR1 coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant TACR1 protein in following stages of expression and purification.
The substance P receptor is officially known as the Tachykinin receptor 1 (TACR1) or neurokinin-1 receptor (NK1R). This receptor is a G protein-coupled receptor that binds specifically to substance P, a neuropeptide involved in neurotransmission, inflammation, and pain signaling. TACR1 is primarily expressed in the central and peripheral nervous systems and plays a crucial role in mediating the effects of substance P. Upon binding of substance P to TACR1, various intracellular signaling pathways are activated, leading to neurogenic inflammation, vasodilation, and modulation of pain perception. The TACR1 receptor is implicated in numerous physiological and pathological processes, making it a significant target for research in areas such as neuroscience, pain biology, and immunology. Understanding TACR1 function is crucial for developing therapeutic interventions related to pain management and inflammatory disorders.
