TACR1

The protein encoded by TACR1 is tachykinin receptor 1, also known as neurokinin 1 receptor (NK1R). It is a G protein-coupled receptor (GPCR) that primarily binds substance P (SP), mediating signaling through Gq/11 proteins to activate phospholipase C and intracellular calcium mobilization.
TACR1 is involved in neuroinflammatory pathways and pain transmission. Its dysregulation is linked to disorders like migraine, depression, and inflammation. While preclinical studies explored NK1R antagonists for these conditions, clinical success has been limited, with some agents discontinued due to efficacy or safety concerns.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TACR1 Recombinant Monoclonal Antibody (CSB-RA555508A0HU)

Validated Data

Western Blot
Positive WB detected in: THP-1 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, Ntera-2 whole cell lysate, Mouse Brain whole cell lysate
All lanes: TACR1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47, 36 kDa
Observed band size: 50 kDa

TACR1 Antibody (CSB-PA09674A0Rb)

Validated Data

Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA09674A0Rb at dilution of 1:100

Immunofluorescent analysis of NIH/3T3 cells using CSB-PA09674A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following TACR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TACR1 Antibodies

TACR1 Proteins

TACR1 ELISA Kits

TACR1 Antibodies

TACR1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA09674A0Rb	TACR1 Antibody	Human	ELISA, IHC, IF
CSB-PA09674C0Rb	TACR1 Antibody, FITC conjugated	Human
CSB-PA09674D0Rb	TACR1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA023068GA01HU	TACR1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA050201	TACR1 Antibody	Human,Mouse,Rat	WB, IF, ELISA
CSB-RA555508A0HU	TACR1 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB

TACR1 Proteins

TACR1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF688584DO	Recombinant Dog Substance-P receptor (TACR1)	in vitro E.coli expression system
CSB-YP688584DO1 CSB-EP688584DO1 CSB-BP688584DO1 CSB-MP688584DO1 CSB-EP688584DO1-B	Recombinant Dog Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TACR1 Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

Code	Product Name	Source
CSB-CF710711MRA	Recombinant Meriones unguiculatus Substance-P receptor (TACR1)	in vitro E.coli expression system
CSB-YP710711MRA1 CSB-EP710711MRA1 CSB-BP710711MRA1 CSB-MP710711MRA1 CSB-EP710711MRA1-B	Recombinant Meriones unguiculatus Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TACR1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF023068RA	Recombinant Rat Substance-P receptor (Tacr1)	in vitro E.coli expression system
CSB-YP023068RA1 CSB-EP023068RA1 CSB-BP023068RA1 CSB-MP023068RA1 CSB-EP023068RA1-B	Recombinant Rat Substance-P receptor (Tacr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TACR1 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-CF023068GU	Recombinant Guinea pig Substance-P receptor (TACR1)	in vitro E.coli expression system
CSB-YP023068GU1 CSB-EP023068GU1 CSB-BP023068GU1 CSB-MP023068GU1 CSB-EP023068GU1-B	Recombinant Guinea pig Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TACR1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF023068MO	Recombinant Mouse Substance-P receptor (Tacr1)	in vitro E.coli expression system
CSB-YP023068MO1 CSB-EP023068MO1 CSB-BP023068MO1 CSB-MP023068MO1 CSB-EP023068MO1-B	Recombinant Mouse Substance-P receptor (Tacr1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TACR1 Proteins for Lithobates catesbeiana (American bullfrog) (Rana catesbeiana)

Code	Product Name	Source
CSB-CF839654LQA	Recombinant Lithobates catesbeiana Substance-P receptor (TACR1)	in vitro E.coli expression system
CSB-YP839654LQA1 CSB-EP839654LQA1 CSB-BP839654LQA1 CSB-MP839654LQA1 CSB-EP839654LQA1-B	Recombinant Lithobates catesbeiana Substance-P receptor (TACR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TACR1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP023068HU CSB-BP023068HU CSB-MP023068HU CSB-EP023068HU-B	Recombinant Human Substance-P receptor (TACR1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023068HU	Recombinant Human Substance-P receptor (TACR1), partial	E.coli

TACR1 ELISA Kit

TACR1 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E08362m	Mouse substance P receptor,SP-R ELISA Kit	serum, plasma, cell lysates, tissue homogenates	1.95 pg/mL

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TACR1

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