Recombinant Human T-box transcription factor TBX3 (TBX3)

1. TBX3 is not only required for development of posterior forelimb bones (ulna and digits 4 and 5), but also for a subset of posterior muscles (lateral triceps and brachialis) and their bone eminence attachment sites. PMID: 27491074
2. High TBX3 expression is associated with invasive breast cancer. PMID: 27553211
3. genetic variation of Tbx3 is associated with left ventricular mass in a healthy Japanese population [meta-analysis] PMID: 27195777
4. Study demonstrates that miR-206 directly targets Tbx3, that miR-206 and Tbx3 mRNA are inversely correlated in human breast cancer and that Tbx3 repression is necessary to elicit a significant functional effect of miR-206 in breast cancer cells. PMID: 27100732
5. The c.1423C>T (p.Q475*) nonsense mutation in exon 6 of the TBX3 gene associated with ulnar-mammary syndrome. PMID: 28145909
6. Tbx3 was found to be overexpressed in 46 of 98 human gastric cancer samples PMID: 27553355
7. Paracrine WNT signaling is stimulated by estrogen and progesterone, while autocrine WNT signaling is induced by the embryonic T-box transcription factor TBX3 PMID: 25350852
8. Overexpression of Tbx3 is associated with pancreatic carcinoma. PMID: 25743805
9. Polymorphisms in several genes involved in the Wnt signaling pathway were associated with hepatic fibrosis or inflammation risk in HCV-infected males. PMID: 24386373
10. TBX3 gene variants may contribute to indirect inguinal hernia as a rare risk factor by reducing TBX3 levels PMID: 25455105
11. An enhancement in TBX3 protein expression both in glomerular and tubular regions. PMID: 25158279
12. The pleiotropic effects of TBX3 mutations in humans and mice likely result from disrupting at least two molecular functions of this protein: transcriptional regulation and pre-mRNA splicing. PMID: 24675841
13. TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion. PMID: 24098938
14. TBX3 plays a pivotal role in mediating the antiproliferative and promigratory role of TGF-beta1 in breast epithelial cells and skin keratinocytes. PMID: 24025717
15. TBX3 exon 2 mutation is rare in most human tumors PMID: 23656610
16. Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion. PMID: 23190890
17. TBX3 gene polymorphism is associated in the development of colorectal cancers. PMID: 23266556
18. Data show that Tbx3 is up-regulated in tissue samples of head and neck squamous cell cancer (HNSCC) patients and that Tbx3 represses PTEN transcription. PMID: 23082988
19. the sequence variants within the TBX3 gene promoter did not contribute to VSD etiology. PMID: 23116943
20. TBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent manner. PMID: 22865636
21. TBX3 CPG island methylation predicts progression in bladder cancer. PMID: 22284968
22. Tbx3 overexpression promotes squamous carcinoma cell survival displaying an epithelial-mesenchymal transition phenotype. PMID: 22154512
23. In situ hybridization reveals Tbx3 and Sox4 to co-localize extensively in the embryo including the atrioventricular and outflow tract cushion mesenchyme and a small area of interventricular myocardium. PMID: 21538160
24. identify a Sp1 element and two CCAAT boxes to be essential for basal TBX3 promoter activity PMID: 21784138
25. Study indicate mutation of TBX3 gene in the family. PMID: 21199695
26. Tbx3 expression was found to be suppressed by AFLL when the expression of tumor suppressor genes p14 and p53 were activated PMID: 20702496
27. Data show that estrogen signaling expands the pool of functional breast cancer stem-like cells through a paracrine FGF/FGFR/Tbx3 signaling pathway. PMID: 21098263
28. pathway that up-regulates TBX3 expression and provides additional evidence that increased levels of TBX3 contribute to metastasis. PMID: 20942798
29. TBX3 mRNA expression was significantly higher in metastatic breast cancer than in non-metastatic tumors. PMID: 19218121
30. Studies identified Tbx3 as a key regulator of the SAN phenotype. PMID: 20133910
31. The mRNA and protein expressions of Tbx3 are markedly upregulated in breast cancer cell lines and tissue samples. PMID: 19403417
32. Mutations in Tbx3 are responsible for ulnar-mammary syndrome (UMS), an autosomal dominant disorder affecting limb, tooth, hair, apocrine gland and genital development. PMID: 11689487
33. Results demonstrate the structural consequences of T-box domain protein 3 point mutations observed in Ulnar-Mammary syndrome and Holt-Oram syndrome patients. PMID: 12005433
34. The results are consistent with the previous finding that UMS is caused by haploinsufficiency of TBX3. PMID: 12116211
35. Overexpression of TBX3 is associated with breast cancer PMID: 15289316
36. increased expression of truncated cSHMT, Tbx3 and utrophin in plasma samples obtained from patients at early stages of ovarian cancer and breast cancer PMID: 16049973
37. A literature review of TBX3 combined with a novel TBX3 mutation in a family with ulnar-mammary syndrome finds an association in mutations that disrupt the TBX3 DNA-binding domain and a higher frequency of severe upper limb malformations and teeth defects. PMID: 16530712
38. Required for heart and limb formation, and is mutated in ulnar-mammary syndrome. PMID: 16556916
39. Data show that Tbx3 plays an important role in osteogenic differentiation and proliferation of human mesenchymal stem cells derived from adipose tissue. PMID: 16955224
40. Nyx2-5 confines recombinant hTBX3 expression to the sinoatrial node & sinus horns in mice. Tbx3 suppresses chamber differentiation--another mechanism by which the Tbx3-positive sinoatrial node is shielded from differentiating into atrial myocardium. PMID: 17234970
41. TBX3 repression to its targets is dependent on HDAC activity. TBX3 may serve as a biomarker for breast cancer. PMID: 18245468

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HGNC: 11602

OMIM: 181450

KEGG: hsa:6926

STRING: 9606.ENSP00000257566

UniGene: Hs.744016