Recombinant Human T-cell leukemia virus 1 Protein Tax-1 (tax)

1. Suggest that HBZ-mediated Foxp3 expression is partly associated with the pathogenesis of HTLV-I-seropositive Sjogren's syndrome. PMID: 29600938
2. High tax expression is associated with persistent HTLV1 infection and leukemogenesis. PMID: 29358408
3. By fluorescence resonance energy transfer (FRET), we detected the direct binding of Tax to DLG1 within the cell. The interaction specifically affects the cellular distribution of not only DLG1, but also Tax. The aggregates distribute into the Golgi apparatus in spatial association with the microtubule-organizing center (MTOC). PMID: 29168728
4. HTLV-1 Tax protein interacts with the central helicase core domain of UPF1 and freezes it, which leads to nonsense-mediated mRNA decay inhibition, which in turn helps HTLV-1 to ensure its own genome expression. PMID: 29382845
5. A Luciferase Functional Quantitative Assay for Measuring NF-kB Promoter Transactivation Mediated by HTLV-1 and HTLV-2 Tax Proteins. PMID: 28357663
6. Human T-lymphotropic virus 1 Tax protein impairs K63-linked ubiquitination of STING and disrupted the interactions between STING and TBK1 to evade host innate immunity. PMID: 28119118
7. Tax interacts with the host OGT/OGA complex and inhibits the activity of OGT-bound OGA. PMID: 28742148
8. Human T-cell leukemia virus type 1 (HTLV-1) Tax directly binds to BCL11B. Tax enhances BCL11B degradation through proteasome pathway. Loss of BCL11B enhances cell growth in HTLV-1-infected cells. PMID: 28669733
9. these results lead us to propose a novel model in which the hybrid-chain-dependent oligomerization of the IkappaB kinase (IKK) complex triggered by Tax leads to trans-autophosphorylation-mediated IKK activation. PMID: 28103322
10. Tax effect on ERalpha induced activation of genes by the classical pathway by testing its influence on E2-induced expression of Eestrogen response element promoter-driven luciferase reporter , is reported. PMID: 27420286
11. In HIV-infected primary resting CD4(+) T cells, Tax-1 reactivated HIV-1 transcription up to five fold in an ex vivo latency model, these results confirm that HTLV-1/Tax hijacks cellular partners, promoting HIV-1 transcription. PMID: 28152383
12. Tax and semaphorin 4D released from lymphocytes infected with human lymphotropic virus type 1 and inhibit neurite growth in a neuron cell line. PMID: 26389656
13. evaluated Tax secretion in peripheral blood mononuclear cell cultures from human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis patients (HAM/TSP) and asymptomatic carriers; also, Tax plasma level was evaluated from other HAM/TSP patients and asymptomatic carriers PMID: 26241614
14. EGR-1 overexpression in Jurkat cells transfected to express Tax, promoted the activation of several genes, especially those that contained AP-1 (Jun/c-Fos), but knockdown of endogenous EGR-1 by siRNA reduced Tax-mediated JNK-1 transcription PMID: 26573109
15. Our studies revealed the biochemical function of Tax in the process of IKK activation PMID: 27082114
16. Tax1-mediated cell survival and death depend on the cell growth phase. PMID: 26829041
17. Thus, CIITA inhibits cytoplasmic and nuclear steps of human T cell lymphotropic virus type 1 Tax-1-mediated NF-kappaB activation. PMID: 26792751
18. HIC specifically interacts with HTLV-1 Tax and negatively regulates Tax transactivational activity by altering its subcellular distribution and stability. PMID: 26469549
19. Study used molecular combing techniques to study the effect of the oncoprotein Tax on DNA replication and found that replication forks have difficulties replicating complex DNA, fork progression is slower, and they pause or stall more frequently in the presence of Tax expression. PMID: 25185513
20. unveiled a previously unidentified role of Foxp3 in T cell transformation, providing a molecular basis for HTLV-1 tax protein transformation of CD4+Foxp3+ T cells PMID: 26381169
21. Study shows selective phosphorylation of PKCdelta in HTLV1infected T cells where Tax activates NFkappaB through PKCdelta activation. PMID: 25625567
22. These results suggest that HTLV-I induces CD83 expression on T cells via Tax1 -mediated NF-kappaB activation, which may promote HTLV-I infection in vivo. PMID: 26129803
23. Mechanistically, MEF-2 was recruited to the viral promoter (LTR, long terminal repeat) in the context of chromatin, and constituted Tax/CREB transcriptional complex via direct binding to the HTLV-1 LTR. PMID: 25809782
24. Tax interacted with and activated TRAF6, and triggered its mitochondrial localization, where it conjugated four carboxyl-terminal lysine residues of MCL-1 with lysine 63-linked polyubiquitin chains PMID: 25340740
25. Tax-1 but not Tax-2 induces cell transformation and increased plasmatocyte proliferation. PMID: 25995252
26. The Tax oncogene enhances ELL incorporation into p300 and P-TEFb containing protein complexes to activate transcription. PMID: 26188510
27. Results indicate that Tax-induced downregulation of Bim in HTLV-1-infected T cells promotes their IL-2-independent growth, thereby supporting the persistence of HTLV-1 infection in vivo. PMID: 25175936
28. Tax confers apoptosis resistance to HTLV-1-infected T cells by suppressing the expression of Bim and Bid. PMID: 25522269
29. Tax is responsible for suppressing BCL11B protein expression in HTLV-1-infected T-cells; Tax-mediated repression of BCL11B is another mechanism that Tax uses to promote oncogenesis of HTLV-1-infected T-cells. PMID: 25613934
30. Tax potently inhibits the activity of DEx(D/H) box helicases RIG-I and MDA5 as well as Toll-dependent TIR-domain-containing adapter-inducing interferon-beta (TRIF), which function as cellular sensors or mediators of viral RNA. PMID: 25694597
31. study identified TCF1 and LEF1 as Tax antagonistic factors in vivo, a fact which may critically influence the peripheral T-cell tropism of this virus PMID: 25646419
32. Data suggest that Tax recruitment of autophagic molecules to lipid rafts is a dominant strategy to deregulate autophagy in the context of HTLV-1 transformation of T cells. PMID: 24362528
33. HTLV-1 Tax is recruited into the TBK1/IKKvarepsilon complexes as a scaffolding-adaptor protein that enhances IFN-beta gene expression. PMID: 25531185
34. exosomes released from HTLV-1-infected Tax-expressing cells contributed to enhanced survival of exosome-recipient cells when treated with Fas antibody PMID: 24939845
35. HTLV-1 Tax SUMOylation is not required for NF-kappaB-driven gene induction. PMID: 24991007
36. Tax transactivates the ELL2 promoter in HTLV-1-infected T-cells. PMID: 25058508
37. The interaction between human T cell lymphotropic virus type-I Tax and calreticulin was determined by confocal microscopy and coimmunoprecipitation. PMID: 24321043
38. NF-kappaB-binding cofactor inhibitor of NF-kappaB-zeta (IkappaB-zeta) is constitutively expressed in HTLV-I-infected T cell lines and ATL cells, and Tax transactivates the IkappaB-zeta gene, mainly through NF-kappaB. PMID: 24027435
39. Brd4 as a key regulator for Tax-mediated NF-kappaB gene expression PMID: 24189064
40. Inhibition of HSP90 activity in HTLV-1-transformed cells elicited proteasomal degradation of Tax in the nuclear matrix and inhibition of NF-kappaB and HTLV-1 long terminal repeat activation. PMID: 24109220
41. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1 infections. PMID: 23816512
42. These findings indicate that Tax enhances the expression of high mobility group box 1 gene at the transcriptional level, possibly by interacting with C/EBP. PMID: 23534754
43. USP10 is a host factor that inhibits stress-induced ROS production and apoptosis in HTLV-1-infected T cells; however, its activities are attenuated by Tax. PMID: 23775713
44. Our results suggest that HTLV-1 Tax1 fails to activate the canonical pathway of NF-kappaB in non-hematopoietic cell lines. PMID: 23791017
45. Authors identified acetyltransferase p300 and deacetylase HDAC7 as enzymes modulating human T cell leukemia virus type 1 Tax protein acetylation. PMID: 23880157
46. Group I p21-activated kinases augment Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats in a kinase-independent manner. PMID: 23622267
47. Tax-specific cytotoxic T-lymphocyte cell treatment significantly decreases human soluble IL-2Rgamma serum concentrations and prolongation of survival time in a mouse model of human adult T cell leukemia/lymphoma. PMID: 23733874
48. These findings revealed a new function of LKB1 and salt-inducible kinases as negative regulators of HTLV-1 transcription. PMID: 23577667
49. Nevertheless, both human T cell leukemia virus type 2 and human T cell leukemia virus type 2 Tax preferentially immortalized CD4(+) T cells, but not CD8(+) T cells. PMID: 23054433
50. Both Tax-1 and Tax-2 activate the NF-kappaB pathway via similar mechanisms involving ubiquitination and sumoylation. PMID: 23217160

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KEGG: vg:1491938