Recombinant Human General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)

1. This study demonstrates that CpG-specific DNA methylation in the ERCC3 promoter region may be involved in benzene-induced epigenetic modification and it may contribute to benzene-induced hematotoxicity. PMID: 28813025
2. An essential role of MYC-ERCC3 interactions in PDAC. PMID: 27384421
3. similar to tumors arising in the background of homologous repair defects, mutations in nucleotide excision repair genes such as ERCC3 could constitute potential therapeutic targets in a subset of hereditary breast cancers. PMID: 27655433
4. results reveal a previously unknown role for transcription factor IIH in ATR kinase activation in non-replicating, non-cycling cells PMID: 28592488
5. Study shows that: mRNA synthesis is sensitive to the inhibition of the ATPase activity of XPB; mRNA synthesis accommodates the depletion of XPB; XPB-depleted TFIIH participates in mRNA synthesis, and finally, XPB ATPase overcomes transcription initiation block imposed by its helicase motifs. PMID: 28157507
6. findings suggest that benzene exposure may be associated with hypermethylation in ERCC3, and that genetic variants in EPHX1 may play an important role in epigenetic changes and hematotoxicity among benzene-exposed workers PMID: 23797950
7. The crystal structure of the C-terminal half of the XPB subunit of TFIIH (residues 494-782) is reported, containing XPB helicase domain (HD)2 and a C-terminal extension which shares structural similarity with RIG-I. PMID: 23385459
8. Phenotype-specific adverse effects of XPD mutations on human prenatal development implicate impairment of TFIIH-mediated functions in placenta. PMID: 22234153
9. reduction in ERCC3 by siRNA interference in human melanocytes in vitro reduced their tyrosinase production ability PMID: 22615732
10. These results indicated that persistent HBV infection might trigger NER impairment in part through upregulation of miR-192, which suppressed the levels of ERCC3 and ERCC4. PMID: 21672525
11. Results show that a deficiency in functional XPB paradoxically renders cells more sensitive to the genotoxic effects of oxidative stress while reducing the cytotoxic effects. PMID: 19840190
12. The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. PMID: 21157430
13. The C1D gene has been identified as one of the major genes whose expression is significantly upregulated by restoring XPB function. PMID: 20530579
14. results demonstrated that a) XP-G/CS mutations affect the disassembly state of TFIIH resulting in the dissociation of CAK, but not XPD from core TFIIH PMID: 20543986
15. TFIIH core subunit p89, but not other subunits of TFIIH, associates with the centrosomes and the adjacent parts of the mitotic spindle during mitosis. PMID: 20208140
16. p52 mediates function within the transcription/repair factor TFIIH. PMID: 12080057
17. Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. PMID: 12393803
18. TFIIH from trichothiodystrophy patients, but not from xeroderma pigmentosum patients, exhibit a significant in vitro basal transcription defect in addition to a reduced intercellular concentration. PMID: 12820975
19. High XRB mRNA levels is associated with Clear cell tumors of epithelial ovarian cancer PMID: 14614013
20. identification of a new, evolutionarily conserved, core TFIIH subunit is essential for our understanding of TFIIH function in transcription, DNA repair and human disease PMID: 15220921
21. Reduced expression of ERCC3 was correlated with esophageal cancer progression PMID: 15375507
22. data support an additional role for XPB in promoting the incision of the damaged DNA fragment and reveal a point of nucleotide excision repair regulation on TFIIH without interference in its transcription activity PMID: 15549133
23. Single Nucleotide Polymorphism in the ERCC3 is associated with lung cancer PMID: 16835333
24. XPB could inhibit the proliferation of hepatoma cells and had a positive effect on the expression of p53 and p21(waf1/cip1) but a negative effect on c-myc. PMID: 16914395
25. Multiple proteins both known and unknown to interact with RAD52 were identified by the "dual-tagging" proteomic method. PMID: 19338310
26. Single Nucleotide Polimorphisms in VEGF and ERCC3 were associated with alterations in White Blood Cells and WBC subtype counts in workers exposed to benzene, even at relatively low levels of exposure below 1 ppm. PMID: 19773279

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HGNC: 3435

OMIM: 133510

KEGG: hsa:2071

STRING: 9606.ENSP00000285398

UniGene: Hs.469872