ERCC3

General transcription and DNA repair factor IIH helicase subunit XPB is a protein in humans that is encoded by ERCC3 gene. ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

ERCC3 Antibodies

ERCC3 Antibodies for Homo sapiens (Human)

ERCC3 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

ERCC3 Proteins

ERCC3 Proteins for Homo sapiens (Human)

ERCC3 Proteins for Mus musculus (Mouse)

ERCC3 Proteins for Bos taurus (Bovine)

ERCC3 Proteins for Rattus norvegicus (Rat)

ERCC3 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

ERCC3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

ERCC3 Proteins for Gallus gallus (Chicken)

ERCC3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

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