Recombinant Human THO complex subunit 7 homolog (THOC7)

Code CSB-YP746911HU
MSDS
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Source Yeast
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Code CSB-EP746911HU
MSDS
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Source E.coli
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Code CSB-EP746911HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP746911HU
MSDS
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Source Baculovirus
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Code CSB-MP746911HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
THOC7
Uniprot No.
Alternative Names
FLJ23445; fSAP24; Functional spliceosome associated protein 24; Functional spliceosome-associated protein 24; hTREX30; Ngg1 interacting factor 3 like 1 binding protein 1; Ngg1 interacting factor 3 like protein 1 binding protein 1; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1 binding protein 1; NIF3L1-binding protein 1; NIF3L1BP1; THO complex 7 homolog (Drosophila); THO complex 7 homolog; THO complex subunit 7 homolog; THOC 7; thoc7; THOC7_HUMAN
Species
Homo sapiens (Human)
Expression Region
2-204
Target Protein Sequence
GAVTDDEVI RKRLLIDGDG AGDDRRINLL VKSFIKWCNS GSQEEGYSQY QRMLSTLSQC EFSMGKTLLV YDMNLREMEN YEKIYKEIEC SIAGAHEKIA ECKKQILQAK RIRKNRQEYD ALAKVIQHHP DRHETLKELE ALGKELEHLS HIKESVEDKL ELRRKQFHVL LSTIHELQQT LENDEKLSEV EEAQEASMET DPKP
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.; The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Gene References into Functions
  1. THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly. PMID: 19059247
Subcellular Location
Cytoplasm. Nucleus. Nucleus speckle.
Protein Families
THOC7 family
Database Links

HGNC: 29874

OMIM: 611965

KEGG: hsa:80145

STRING: 9606.ENSP00000295899

UniGene: Hs.288151

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