Recombinant Human Trafficking kinesin-binding protein 2 (TRAK2), partial

Code CSB-YP024220HU
MSDS
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Source Yeast
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Code CSB-EP024220HU
MSDS
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Source E.coli
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Code CSB-EP024220HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP024220HU
MSDS
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Source Baculovirus
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Code CSB-MP024220HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
TRAK2
Uniprot No.
Alternative Names
ALS2CR 3; ALS2CR3; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein; CALS C; GRIF 1; GRIF1; KIAA0549; OIP98; Trafficking kinesin-binding protein 2; Trafficking protein kinesin binding 2; Trak2; TRAK2_HUMAN
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.
Gene References into Functions
  1. This study showed that the TRAK2 was more prevalent in dendrites of hippocampal neurons. In cortical neurons, TRAK2 was equally distributed between axons and dendrites. PMID: 25653102
  2. The results of this study established a key role for mammalian TRAK2 proteins in axonal and dendritic targeting of mitochondria. PMID: 23395375
  3. identification, molecular cloning and characterization PMID: 12034717
  4. GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1 PMID: 15644324
  5. analysis of the GRIF-1 binding domain of the kinesin, KIF5C, which substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes PMID: 16835241
  6. Binds to Kir2.1 and facilitates trafficking of this channel to the cell surface. PMID: 16895905

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Subcellular Location
Cytoplasm. Early endosome. Mitochondrion.
Tissue Specificity
Widely expressed, with highest expression in heart.
Database Links

HGNC: 13206

OMIM: 607334

KEGG: hsa:66008

STRING: 9606.ENSP00000328875

UniGene: Hs.152774

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