Recombinant Human Tribbles homolog 1 (TRIB1)

1. findings support the hypothesis that TRIB1 gene expression in human umbilical vein endothelial cells depends on the duration of intrauterine exposure to hyperglycaemia PMID: 29502537
2. our study reveals that TRIB1 promotes CRC cell migration and invasion by up-regulating the expression of MMP-2 via the activation of FAK/Src and ERK pathways, knockdown of TRIB1 expression in CRC cells abolishes these effects. PMID: 28624785
3. role of TRIB1 in cell cycle and survival that is mediated via the modulation of NFkappaB signaling. PMID: 28087598
4. the co-operativity observed between MYC and TRIB1 in the absence of PML/RARA show that, outside of acute promyelocytic leukemia, gain of both genes may drive selection for trisomy 8. PMID: 27390356
5. The crucial role of TRIB1 in cisplatin-induced enrichment of CSC and drug resistance was verified by knockdown TRIB1. Interestingly, cisplatin treatment also contributed to the increasement of HDAC, the interaction of TRIB1 with HDAC, and inactivation of p53. PMID: 28406482
6. Trib1 formed a complex with pHDAC1. PMID: 26521947
7. Studies indicate that tribbles homolog 1 (Drosophila) protein appear to be involved in some of the most common diseases, such as cancer, metabolic disease and hyperlipidaemia. PMID: 26517921
8. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis. PMID: 26517922
9. Studies indicate that the minor allele of a single nucleotide polymorphism (SNP, rs6982502) in the regulatory sequence reduces the activity of the tribbles homolog 1 (Drosophila) protein (TRIB1) promoter. PMID: 26517924
10. Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 were involved in the pathogenesis of inflammation. PMID: 26517925
11. Studies indicate that tribbles homolog 1 (Drosophila) protein (TRIB1) interacts with the master molecule of Tregs, forkhead box P3 (FOXP3), a transcription factor essential for Treg suppressive activity. PMID: 26517926
12. Studies indicate that tribbles homolog 1 (Drosophila) protein (tribbles-1; TRIB1) is an important modulator of human energy metabolism and metabolic syndromes. PMID: 26517927
13. Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 and TRIB3 in cells and intact organisms, serving as guides for the development of new drugs. PMID: 26517930
14. Studies indicate that overexpression of the wild-type tribbles homolog 1 (Drosophila) protein (Trib1) gene effectively induces leukaemia. PMID: 26517931
15. Studies show that TRIB1 and TRIB2 are highly expressed in molecularly-defined sub-types of acute myeloid leukemia (AML). PMID: 26517933
16. Studies show a remarkable reduction in tribbles 2 protein (Trib2) expression during oocyte maturation whereas tribbles 1 protein (Trib1) and tribbles 3 protein (Trib3) expression was significantly increased during this process. PMID: 26517934
17. SNP rs17321515 associated with plasma triglycerides level and increasing risk of coronary heart disease in male Chinese Han population PMID: 25986010
18. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression. PMID: 25921304
19. TRB1 negatively regulates tumor-suppressor activity of p53 through p53 deacetylation PMID: 25832642
20. trait-specific genetic risk scores are robustly associated with 10-yr changes in lipid levels and three individual SNPs in APOE, TRIB1, and APOA1 were strongly associated with 10-yr changes in lipid levels PMID: 24922540
21. our study indicated that the TRIB1 gene, especially the rs2980879 polymorphism, is related to the development of pancreatic cancer in the Chinese Han population. PMID: 25117373
22. genetic association studies in Japan: Data suggest SNPs in TRIB1 (rs2954021), GCKR (glucokinase regulatory protein, rs780094), and PNPLA3 (patatin-like phospholipase domain containing 3, rs738409) are associated with nonalcoholic fatty liver disease. PMID: 24785259
23. TRIB1 was related to endoplasmic reticulum (ER) pathways. PMID: 24962028
24. association with plasma triglyceride concentrations PMID: 24895164
25. The TRIB1 rs2954029 is associated with serum triglyceride concentrations in Japanese community-dwelling women. PMID: 24910200
26. These data suggested that the modulation of TRIB1 expression affects hepatic lipogenesis and glycogenesis through multiple molecular interactions. PMID: 24389359
27. High TRIB1 expression is associated with prostate cancer. PMID: 24382668
28. Trib1 acts as an activator of the MAPK pathway. PMID: 24161842
29. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial. PMID: 23550039
30. tribbles-1 is a novel binding partner of Foxp3 in regulatory T cells PMID: 23417677
31. Allelic variants of TRIB1 are independently involved in regulation of lipid metabolism and sleep. PMID: 22832862
32. Studies indicate that three loci for lipid levels identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functional variant at SORT1. PMID: 22418572
33. Studies indicate tribbles 1 and tribbles 3 as regulators of lipid level and disease susceptibility genes in metabolic syndrome and type 2 diabetes. PMID: 22274752
34. TRIB1 R107L gain-of-function mutation is associated with acute megakaryocytic leukemia. PMID: 22294728
35. The associations of TRIB1 rs17321515 SNP and serum lipid levels are different between the Mulao and Han populations. PMID: 22145581
36. genetic association studies in Spain: A TRIB1 SNP (rs17321515) is associated with familial hypercholesterolemia. Smoking status and presence of arcus cornealis modulate effect of this TRIB1 SNP on plasma lipid levels in such patients. PMID: 20692138
37. Data show no differences in triglyceride or total cholesterol levels in relation to any allelic variants of ANGPTL3, CILP2, or TRIB1 SNPs. PMID: 21691831
38. TRIB1 polymorphisms were associated with increased risk of ischemic heart disease and myocardial infarction. PMID: 21071687
39. Tribbles homolog 1 (Trib1) functions as a negative regulator of retinoic acid receptors. PMID: 21053424
40. Trib1 may be a key mediator between the RTK-MAPK pathway and the C/EBP transcription factor in myeloid leukemogenesis. PMID: 20610816
41. low trb-1 expression was associated with inactive C/EBPalpha PMID: 20005259
42. Data show that SNPs associated with TG in normolipidemic samples, including APOA5, TRIB1, TBL2, GCKR, GALNT2 and ANGPTL3 were significantly associated with HLP types 2B, 3, 4 and 5. PMID: 19656773
43. Tribbles controls both the extent and the specificity of MAPK kinase activation of MAPK PMID: 15299019
44. used chemical shift perturbation experiments to show the possible SKIP binding interface on PPIL1 PMID: 16595688
45. trb-1 has an important role in vascular smooth muscle cell biology PMID: 17452330

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HGNC: 16891

OMIM: 609461

KEGG: hsa:10221

STRING: 9606.ENSP00000312150

UniGene: Hs.444947