Recombinant Human V-type proton ATPase subunit G 1 (ATP6V1G1)

Code CSB-EP002408HU
Size $224
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity
Greater than 90% as determined by SDS-PAGE.
Target Names
ATP6V1G1
Uniprot No.
Research Area
Transport
Alternative Names
ATP 6G; ATP 6J; ATP6G; ATP6G1; ATP6GL; Atp6v1g1; ATPase H+ transporting lysosomal (vacuolar proton pump) member J; ATPase H+ transporting lysosomal 13kD V1 subunit G isoform 1; ATPase H+ transporting lysosomal 13kDa V1 subunit G1; ATPase H+ transporting lysosomal member J; ATPase H+ transporting lysosomal subunit G isoform 1; DKFZp547P234; V ATPase 13 kDa subunit 1; V ATPase G subunit 1; V-ATPase 13 kDa subunit 1; V-ATPase subunit G 1; V-type proton ATPase subunit G 1; Vacuolar ATP synthase subunit G 1; Vacuolar ATP synthase subunit G1; Vacuolar ATP synthase subunit M16; Vacuolar H+ ATPase G1; Vacuolar H+ ATPase subunit G 1; Vacuolar proton pump G subunit 1; Vacuolar proton pump subunit G 1; Vacuolar proton pump subunit M16; VATG1_HUMAN; Vma 10; Vma10
Species
Homo sapiens (Human)
Source
E.coli
Expression Region
2-118aa
Target Protein Sequence
ASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
40.6kDa
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal GST-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.
Gene References into Functions
  1. RILP regulates vacuolar ATPase through interaction with the V1G1 subunit PMID: 26180254
  2. genome-wide association study in population in China: Data suggest 4 SNPs upstream of ATP6V1G1 (rs10817638, rs7851259, rs10982287, rs4979427) are associated (in bivariate manner) with age at menarche and bone density. [includes META-ANALYSIS] PMID: 26312577
  3. RILP regulates the activity of the V-ATPase through its interaction with V1G1. PMID: 24762812
Subcellular Location
Apical cell membrane.
Protein Families
V-ATPase G subunit family
Tissue Specificity
Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level). Ubiquitous.
Database Links

HGNC: 864

OMIM: 607296

KEGG: hsa:9550

STRING: 9606.ENSP00000363162

UniGene: Hs.388654

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