Recombinant Human WAS/WASL-interacting protein family member 1 (WIPF1)

1. WIP deficiency should be considered as a cause for autosomal-recessive immunodeficiency PMID: 27742395
2. the present study identifies the WIPF1 gene as having novel oncogenic functions and playing an important role in the invasiveness and aggressiveness of thyroid cancer when aberrantly up-regulated by the BRAF V600E/MAPK pathway through its promoter demethylation. PMID: 27863429
3. WIP controls tumor growth by boosting signals that stabilize the YAP/TAZ complex via a mechanism mediated by the endocytic/endosomal system. PMID: 27851961
4. Results suggest that local invasiveness of ameloblastoma is dependent upon the migratory potential of its tumour cells as defined by their distribution of cortactin, N-WASP and WIP in correlation with F-actin cytoskeletal dynamics. PMID: 26752341
5. establish a new cancer stem cell signalling pathway downstream of mtp53 in which AKT2 regulates WIP and controls YAP/TAZ stability. PMID: 28166194
6. Knocking down WIP expression in A549 cells significantly reduced RhoA levels and WIP was found to interact with RhoA suggesting that WIP might be executing its function by regulating RhoA. PMID: 27939884
7. Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation. PMID: 27009365
8. WIP was shown to interact with various binding partners, including the signaling proteins Nck, CrkL and cortactin. PMID: 22837718
9. These findings reveal WIP as a previously unreported regulator of neuronal maturation and synaptic activity PMID: 21810783
10. These findings indicate that WIP deficiency should be suspected in patients with features of WAS in whom WAS sequence and mRNA levels are normal. PMID: 22231303
11. show that the N-WASP EVH1 domain specifically binds a 25 residue motif from the WASP Interacting Protein (WIP) PMID: 12437929
12. Only in the presence of WASP-interacting protein (WIP) can human WASP suppress the growth defect of Saccharomyces cerevisiae las17Delta strain. PMID: 16488394
13. A 1.3 mD multiprotein complex consisting of WASp-interacting protein (WIP), Wiskott-Aldrich syndrome protein (WASp), actin, and myosin IIA formigg during NK cell activation was identified with a role in complex formation and NK cell activity regulation. PMID: 16606694
14. WASP-interacting protein stabilizes Wiskott-Aldrich syndrome protein(WASP) and suggest that it may also be important for its function PMID: 17213309
15. In this review, in addition to its WASP-independent functions, the role of WIP is to regulate the activity and stability of WASP and shuttle WASP to areas of actin assembly. PMID: 17949983
16. WIP is involved in lytic granule transport and is essential for regulation of Natural killer cell cytotoxic function PMID: 18258743
17. Groups of colorectal cancer, breast cancer, and glioma patients with low expression of the WIPF1 co-expression module generally had a favorable prognosis. PMID: 19399471

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HGNC: 12736

OMIM: 602357

KEGG: hsa:7456

STRING: 9606.ENSP00000352802

UniGene: Hs.128067