Recombinant Human Wiskott-Aldrich syndrome protein family member 3 (WASF3)

1. Study demonstrated that the expression levels of WAVE3 in pancreatic cancer tissues were prominently higher than those in the non-cancerous tissues which seems to be associated with lymphatic metastasis, poorly differentiated tumors. Furthermore, findings suggest that WAVE3 influences cell proliferation, migration and invasion via the AKT pathway. PMID: 29845225
2. Results suggest that Wiskott-Aldrich syndrome verprolin-homologous protein 3 (WAVE3) may be pivotal in ovarian cancer cell motility, invasion and oncogenesis. PMID: 28476025
3. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion PMID: 28794159
4. we show that WASF3 is present in the HER2 immunocomplex and suppression of WASF3 function leads to suppression of invasion even in the presence of HER2 expression.The engagement of WASF3 with the HER2/HER3 complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2/HER3 activation of JAK/STAT signaling. PMID: 26804171
5. It was concluded that WAVE3 may represent a new adverse prognostic factor for patients with ICC. PMID: 26971088
6. studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis PMID: 28233357
7. Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 cells through their interaction with the ARP2/3 complex. PMID: 26977009
8. stabilization of WASF3 function occurs through its interaction with ATAD3A and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles PMID: 25823022
9. We show that WAVE3-mediated modulation of NFkappaB is required for invadopodia formation as well as MMP9 expression and activity that are needed for cancer cells to degrade the ECM PMID: 25329315
10. WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells. PMID: 25661390
11. WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail. PMID: 25378074
12. miR-217 functions as a tumor-suppressive miRNA and inhibits the osteosarcoma tumorigenesis through targeting WASF3. PMID: 25289936
13. Upregulated WAVE3 expression is essential for TGF-beta-mediated EMT and metastasis of triple-negative breast cancer cells. PMID: 24197660
14. ZEB1/2 upregulation by WASF3 results from downregulation of KISS1, leading to the release of inhibition of nuclear factor (NF)kappaB by IkappaBalpha PMID: 23318438
15. these results define a novel signaling network whereby JAK2/STAT3 signaling creates a feed-forward loop to raise activated WASF3 levels that promote cancer cell motility. PMID: 23677069
16. MMP-9 and WAVE3 were over-expressed in colorectal cancer tissues compared with normal mucosa. PMID: 22806308
17. demonstrate WASF3 is a HIF1A-regulated gene and suggests a mechanism to explain the observation of elevated expression of WASF3 in advanced stage tumors PMID: 22581642
18. increased expression levels of WAVE3 are associated with the progression and metastasis of triple negative breast cancer PMID: 22952619
19. WAVE3-depleted breast cancer cells move more slowly but more persistently on a 2-dimensional matrix. They typically only show one lamellipod. WAVE3 appears to have no role in driving invasiveness. Lamellipodial persistence is not crucial in 3-dimensions. PMID: 22909346
20. HSP90 and HSP70 proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein. PMID: 22315230
21. coordinated expression patterns of the WASF3 metastasis promoter gene and the KISS1 metastasis suppressor gene appear to exert their influence through inhibition of NF-kappaB signaling, which in turn regulates MMP-9 production facilitating invasion. PMID: 21544801
22. The study also identifies a critical role for WAVE3, downstream of miR-31, in the invasion-metastasis cascade. PMID: 21105030
23. WAVE3 is pivotal in controlling the invasiveness of prostate cancer cells. PMID: 19395286
24. Studies identified a novel mechanism for the regulation of WAVE3 expression in cancer cells, which controls the invasive properties and morphology of cancer cells associated with their metastatic potential. PMID: 19801681
25. patient with ganglioneuroblastoma carries an apparently balanced t(1:13)(q21:q12) reciprocal translocation. Positional cloning of the translocation breakpoint on chromosome 13 resulted in the mapping of the breakpoint between coding exon 2 and 3 of WAVE3 PMID: 12185600
26. during megakaryocytic differentiation, platelets expressed WAVE-1 and WAVE-2, whereas WAVE-3 expression was hardly to be detected. WAVE-3 expression was not changed by the differentiation PMID: 15670045
27. all three Scar/WAVE isoforms behave similarly and are likely to participate in the same kinds of protein complexes that regulate actin assembly PMID: 15752430
28. WAVE3-mediated migration in MDA-MB-231 cells via lamellipodia formation is activated downstream of PI3K and induced by PDGF PMID: 15826941
29. The WAVE3 is a member of the WASP/WAVE family of proteins, which play a critical role in the regulation of actin polymerization, cytoskeleton organization, and cell motility. PMID: 15907837
30. the activation of WAVE3 to promote actin remodeling is enhanced by the c-Abl-mediated tyrosine phosphorylation of WAVE3. PMID: 17623672

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HGNC: 12734

OMIM: 605068

KEGG: hsa:10810

STRING: 9606.ENSP00000335055

UniGene: Hs.618732