Recombinant Human cGMP-dependent protein kinase 1 (PRKG1)

1. our study provides the first genome-wide evidence regarding a mechanism by which traumatic life events interact with human genetic variation of PRKG1 in relation to alcohol misuse PMID: 28265120
2. Disulfide-activated PKGIalpha regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response. PMID: 27782102
3. PRKG1, known to induce apoptosis when activated, is increased in all patient derived glioblastoma spheres PMID: 27564115
4. redox-mediated guidance required PKG1 and consequently, its deficiency in vivo resulted in defective repair and enhanced neuropathic pain after nerve injury. PKG1-dependent repair functions will outweigh its signaling functions in spinal nociceptive LTP, so that inhibition of PKG1 is no option for neuropathic pain. PMID: 27978504
5. Oxidant signaling underlies PKGIalpha modulation of Ca2+ sparks and BKCa in myogenically active arterioles PMID: 27729549
6. These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG II. PMID: 28793191
7. Hence, SO2 exerted its vasodilatory effects at least partly by promoting disulfide-dependent dimerization of sGC and PKG, resulting in an activated sGC/cGMP/PKG pathway in blood vessels. These findings revealed a new mode of action and mechanisms by which SO2 regulated the vascular tone. PMID: 27009048
8. these data indicate PKG as an intermediary in EGFR-mediated cell death, likely via apoptotic pathway. PMID: 27381222
9. The heterozygous c.530G>A:p.Arg177Gln PRKG1 variant was associated with early-onset thoracic aortic aneurysm and dissection in a Spanish family. PMID: 27442293
10. cAMP is a partial agonist for PKG, and we elucidate the mechanism for cAMP partial agonism through the comparative NMR analysis of the apo, cGMP-, and cAMP-bound forms of the PKG cyclic nucleotide-binding domain B. PMID: 26370085
11. Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing PMID: 25900831
12. The C42-C42' disulfide bond dramatically stabilizes PRKG1. PMID: 26132214
13. The Golgi apparatus regulates PKGIalpha compartmentation and proteolysis. PMID: 25855081
14. Study of genetic heterogeneity in systemic lupus erythematosus, the top associations in European ancestry were protein kinase, cyclic GMP-dependent, type I (PRKG1) rs7897633 (P(Meta) = 2.75 x 10(-8)) and purine nucleoside phosphorylase (PNP) rs1049564 (P(Meta) = 1.24 x 10(-7)). PMID: 25338677
15. Expression levels of miR-517a-3p and its target mRNA PRKG1 were inversely correlated in NK cells before and after obstetric delivery. PMID: 25273530
16. miR-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells PMID: 25447536
17. Data show that functional cGMP/protein kinase G type 1 (PKG1) is expressed in pancreatic adenocarcinoma cells. PMID: 24826884
18. These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function. PMID: 23755100
19. Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design. PMID: 25271401
20. Leucine296 and Arginine297 are key residues of PKG I that mediate cGMP selectivity. PMID: 24239458
21. These data suggest that increased PKG II activity attenuates bFGFinduced proliferation and migration by inhibiting the MAPK/ERK signaling pathway, whereas PKG I does not PMID: 23404188
22. nitration of Tyr(247) and the attenuation of cGMP binding is an important mechanism regulating in PKG-1alpha activity and SMC proliferation/differentiation PMID: 24469460
23. Authors show for the first time that PKG is also able to stably interact with a viral substrate, West Nile virus NS5, in cell culture and in vitro. PMID: 23876037
24. These findings indicate that PRKG1 risk alleles associate with salt-sensitivity related to a loss of the inhibitory control of renal Na(+) reabsorption, suggestive of a blunt pressure-natriuresis response. PMID: 24060892
25. left ventricular systolic radial function was associated with common polymorphisms in PRKG1. PMID: 24060898
26. Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. PMID: 23910461
27. activation of PKGI with cGMP regulated SSG1 intracellular distribution. PMID: 23831687
28. ANP attenuates the inflammatory actions of histamine via endothelial GC-A/cGMP/cGKI signaling and inhibitory phosphorylation of TRPC6 channels. PMID: 23814119
29. The data suggest that PKGIbeta enhances breast cancer cell motility and invasive capacity, at least in part, by phosphorylating CaD. PMID: 23418348
30. PKG positively regulates proteasome activities and proteasome-mediated degradation of misfolded proteins, likely through posttranslational modifications to proteasome subunits. PMID: 23770744
31. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner PMID: 23686857
32. The cyclic GMP-dependent kinase Ialpha -induced RhoA activation is dependent on the activity of ROCK and serine/threonine phosphatases. PMID: 23195829
33. Studies indicate the presence of the switch helix (SW), a novel motif that promotes the formation of a domain-swapped dimer in the asymmetric unit. PMID: 23416533
34. Low myocardial PKG activity in heart failure with preserved ejection fraction was associated with raised cardiomyocyte F(passive) and was related to increased myocardial nitrosative/oxidative stress. PMID: 22806632
35. RhoA is a PKGIalpha target and direct binding of activated PKGIalpha to RhoA is central to cGMP-mediated inhibition of the VSMC Rho kinase contractile pathway PMID: 23066013
36. Downregulation of PKG1 was associated with malignant and benign breast tumors. PMID: 22791569
37. These results suggest that DAPK2 is one of the targets of cGK-I in apoptosis induction. PMID: 22580283
38. PKGIbeta inhibited cell growth and inducd apoptosis in breast cancer cells. PMID: 22095901
39. cGMP-dependent protein kinase (PKG) Ialpha transfection significantly attenuated the hypoxia-induced down-regulation of the expressions of SM-alpha-actin, MHC and calponin. PMID: 22293199
40. found in smooth muscle wall of blood vessels transversing the clitoral supepithelial and stromal space PMID: 21697861
41. Cyclic 3',5'-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia. PMID: 21563174
42. cGMP dependent kinase 1 alpha interacts with and phosphorylates transient receptor potential cation channel subfamily C member 7 PMID: 21402151
43. data suggest that activation of PKG signaling in pericytes inhibits focal adhesion formation by inhibiting Rac1 PMID: 21451103
44. NO, depending on its concentration, may act in human PBMCs as a stimulator of IL-6 expression and modulator of NF-KB involving the sGC/cGMP/PKG pathway PMID: 21414799
45. The mechanism of cyclic nucleotide binding to PKG was investigated by determining crystal structures of the amino-terminal cyclic nucleotide-binding domain (CNBD-A) of human PKG I bound to either cGMP or cAMP. PMID: 21526164
46. The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury. PMID: 21479273
47. These findings provide evidence of a physical and compartmentalized association between SERT and PKGIalpha that supports. PMID: 19656393
48. A novel mechanism has been elucidated that is able to increase PKG-I protein content in contractile cells, with hypotensive consequences in rat thoracic aorta. PMID: 21160032
49. disruption of the IP3R1-IRAG calcium regulation system is a novel cause of dysfunctional osteoclasts unrelated to defects in attachment proteins or acid secretion PMID: 20567233
50. structure provides molecular details of this unique leucine/isoleucine zipper, revealing specific hydrophobic and ionic interactions that mediate dimerization and demonstrating the topology of the GKAP interaction surface. PMID: 20826808

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HGNC: 9414

OMIM: 176894

KEGG: hsa:5592

UniGene: Hs.407535