Recombinant Human cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A), partial

1. PDE3A is downregulated in chemoresistant NSCLC cells due to DNA hypermethylation. PMID: 28678321
2. Vulnerability to antineoplastic phosphodiesterase inhibitors inhibitors has been associated with co-expression of PDE3A and SLFN12 in various tumor types. PMID: 29107068
3. We found a novel heterozygous missense mutation c.1336T>C in exon 4 of the PDE3A gene in a Japanese family with multiple HTNB patients. This mutation was found to be completely linked to the family members who inherited this condition. PMID: 27053290
4. The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF response in a large UK rheumatoid arthritis cohort. PMID: 27180831
5. PDE3A is a low-affinity and high-velocity enzyme for hydrolysis of cUMP in cardiac myocytes. PMID: 27975297
6. Chemical proteomics results show that besides known interactors such as 14-3-3 family proteins, PDE3A was found to associate with a PP2A complex composed of a regulatory, scaffold and catalytic subunit. PMID: 26205238
7. We found a highly significant association between PDE3A-SLCO1C1 and the clinical response to TNF blockers PMID: 25403996
8. A heterozygous missense mutation in PDE3A causes autosomal dominant hypertension with brachydactyly. PMID: 25961942
9. PDE3A is part of a SERCA2 signaling complex in cardiac myocytes. PMID: 25593322
10. the genotypic and allelic frequencies of the rs7134375 SNP are different between the Mulao and Han populations. the PDE3A rs7134375 SNP is associated with serum TG levels in the Mulao population, however, not in the Han population. PMID: 24604378
11. The PDE3A-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF treatment response. PMID: 23651021
12. PI3Kgamma coordinates the coincident signaling of the major cardiac PDE3 and PDE4 isoforms, thus orchestrating a feedback loop that prevents calcium-dependent ventricular arrhythmia. PMID: 23008439
13. Anagrelide suppresses megakaryocytopoiesis by reducing the expression levels of GATA-1 and FOG-1 via a PDEIII-independent mechanism that is differentiation context-specific and does not involve inhibition of MPL-mediated early signal transduction events PMID: 20586925
14. Data show that PDE3A inhibition augments CFTR-dependent submucosal gland secretion and actin skeleton disruption decreases secretion. PMID: 20089840
15. There was a concentration-dependent inhibition in the increase of intracellular Ca2+ with PDE3 inhibition and significantly less with PDE2 inhibition. PMID: 12038792
16. These findings suggest that alternative processing of the PDE3A gene results in the generation of two mRNAs and three protein isoforms in cardiac myocytes that differ in intracellular localization and may be regulated through different signaling pathways. PMID: 12154085
17. PDE3A gene transcript levels are increased in the intrapulmonary and resistance pulmonary arteries by chronic hypoxia. PMID: 12466227
18. Presence of phosphodiesterase type 3 A (PDE 3A) mRNA was confirmed in human germinal vesicle-stage (GV) oocytes. A selective PDE 3 inhibitor, Org 9935, arrested oocytes retrieved from immature follicles in prophase I for up to 72 h. PMID: 12773402
19. PDE3, but not of PDE5, extends to all major processes in thrombus formation: assembly of platelets into aggregates, secretion of autocrine products, and procoagulant activity. PMID: 15041473
20. 14-3-3 Proteins can discriminate between sites in a region of multisite phosphorylation on PDE3A; the cytoskeletal cross-linker protein plectin-1 coimmunoprecipitated with PDE3A independently of 14-3-3 binding. PMID: 16153182
21. cGMP may amplify cAMP-mediated signaling in intracellular compartments of myocardium by PDE3-dependent and PDE3-independent mechanisms. PMID: 16172121
22. structure-function analysis of the catalytic region of human platelet phosphodiesterase 3A PMID: 16873361
23. The positive-feedback loop described in this review is regulated by phosphodiesterase 3A and inducible cAMP early repressor (ICER) and is pathologically important in adult hearts. PMID: 17332439
24. activation/phosphorylation of PDE3A via Akt signaling pathway participates in regulating cAMP during thrombin activation of platelets. PMID: 17392505
25. platelet activation stimulates PKC-dependent phosphorylation of PDE3A on Ser(312), Ser(428), Ser(438), Ser(465), and Ser(492) leading to a subsequent increase in cAMP hydrolysis and 14-3-3 binding. PMID: 19261611

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HGNC: 8778

OMIM: 112410

KEGG: hsa:5139

STRING: 9606.ENSP00000351957

UniGene: Hs.386791