Recombinant Insulin-like receptor (daf-2), partial

1. neuron-class-specific alternative splicing determined by the combinatorial action of RBFOX proteins (ASD-1 and FOX-1), UNC-75/CELF and PTB-1/PTB PMID: 27198602
2. Suggest mbk-1 as a novel regulator of C. elegans longevity upon both, germline ablation and DAF-2 inhibition, and provide evidence for mbk-1 regulating DAF-16 activity in germline-deficient animals. PMID: 28562327
3. Five MMP alleles proved to be novel dauer-enhancing mutations, including one new allele in the previously uncharacterized C-terminus of DAF-2 CRISPR-Cas9 genome editing was used to confirm the phenotypic consequence of six of these DAF-2 mutations and to replicate an allelic series of known human disease mutations in a highly conserved tyrosine kinase active site residue PMID: 27856697
4. Cholesterol is required for the fasting-induced upregulation of transcriptional target genes such as the insulin/IGF-1 pathway effector DAF-16, and cholesterol deprivation suppresses the long lifespan of the insulin/IGF-1 receptor daf-2 mutant. Remarkably, we found that cholesterol plays an important role in the fasting-induced nuclear accumulation of DAF-16. PMID: 27989925
5. this study shows that heat shock increases the life span of wild type Caenorhabditis elegans upon pathogenic encounter; similar increase in resistance towards pathogenesis observed in long-lived C. elegans daf-2 mutants PMID: 27317398
6. this study shows that daf-2(-) mutants are hyper-immune and exhibit reduced pathological consequences during challenge with Coxiella burnetii PMID: 27884946
7. Results indicates a contribution of daf-2-mediated insulin signalling in the transition from local area search to dispersal in food-associated behaviour in adult C. elegans PMID: 27209024
8. The long-lived mutant daf-2(m41) worms are metabolically youthful compared to wild-type worms, but this relative youth only appears in middle age. PMID: 26381038
9. daf-2(e1370) mutation improves quality of life and lifespan extension. PMID: 26586186
10. These results reveal a new function for daf-2 signaling, and, most importantly, demonstrate that genetic programming contributes to freezing survival. PMID: 26635120
11. Insulin signalling regulates gene expression during cold tolerance. Insulin released from pheromone-sensing neurons is received by the intestine and neurons regulating gene expression for cold habituation. PMID: 25048458
12. When daf-2 animals were incubated at 20 degrees C they remained long-lived, but nuclear appearance changed at similar rate as in the wild type. PMID: 24671263
13. Integrated our proteomic data set together with a selection of other data in an attempt to reconstruct and resolve the intricacies of altered daf-2 metabolism. PMID: 24555535
14. in the presence of food, the DAF-2 insulin-like receptor signals through the RAS-ERK pathway to drive meiotic prophase I progression and oogenesis; in the absence of food, there is downregulation of the RAS-ERK pathway, and oogenesis is stalled. PMID: 24120884
15. Reconciliation of daf-2 suppression by elt-3 in Caenorhabditis elegans from Tonsaker et al. (2012) and Kim et al. (2012). PMID: 23262285
16. The modulation of DAF-2 protein level by nutritional status may constitute an important component in the irreversible commitment to dauer arrest. PMID: 22123849
17. The daf-2 insulin-signaling mutant is able to reduce uterine masses at extreme age. PMID: 22562940
18. Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegans. PMID: 22116032
19. The daf-2 pathway suppressed vitellogenesis through transcriptional mechanisms reflecting reproductive phenotypes, as well as distinct posttranscriptional mechanisms. PMID: 21749693
20. Data show that glucose stress, oga-1 mutants, and ogt-1 mutants each result in an increase in daf-2 carbohydrate storage. PMID: 21441213
21. Proteomic analyses of the environmentally resistant and 'nonaging' C. elegans dauer stage and long-lived daf-2 mutants has provided a unique insight into the protein changes which mediate survival against endogenously produced toxins. PMID: 20392130
22. daf-2(e1370) and daf-2(e1370);pept-1(lg601) animals were compared with a focus on genes that showed significantly higher changes in expression levels in daf-2;pept-1 than in daf-2. PMID: 20550516
23. These results suggest that polyunsaturated fatty acids (PUFA) act as mediators of daf-2/insulin signaling and that daf-16 might be involved in fatty acid homeostasis under the control of PUFA. PMID: 20226839
24. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly, demonstrates no extension in long-term memory with age. PMID: 20502519
25. analysis of how divergent mechanisms control hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway PMID: 19936206
26. daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the signaling pathway of this protein PMID: 12654727
27. daf-2 mutants were resistant to killing by Enterococcus faecalis, Staphylococcus aureus, and Pseudomonas aeruginosa PMID: 12817143
28. Role of DAF-2 in longevity and aging, and interactions with DAF-16, are reviewed. PMID: 14516929
29. findings show that reducing daf-2 mutant activity further by subjecting weak daf-2 mutants as young larvae to dal-2 RNA interference (RNAi) produced larger increases in life-span without triggering dauer formation PMID: 14576426
30. The DAF-2 pathway happens in several organisms and mounted drug discovery programs around those targets. PMID: 15217602
31. DAF-2 signaling controls mitochondrial bioenergetics by adjusting the rate of ATP synthesis to the rate of ATP utilization and by regulating the heat-producing proton leak pathway. PMID: 15708444
32. Data show that an activated Ras mutation, let-60, weakly suppresses constitutive dauer diapause in daf-2 and age-1 (PI3K) mutants. PMID: 16164423
33. REVIEW: role of DAF-2/insulin signaling on lifespan PMID: 16441841
34. daf-2 has a role in conversion of fat to carbohydrate, and conservation of ATP stocks PMID: 16522328
35. isolated dauer-formation mutations in C. briggsae, a species closely related to the model organism C. elegans and identified mutations in orthologs of C. elegans genes daf-2, daf-3 and daf-4 PMID: 17660533
36. 86 proteins identified that were more or less abundant in long-lived daf-2 mutant worms; genetic studies on a subset of the proteins indicated they act in one or more processes regulated by DAF-2, including entry into the dauer developmental stage & aging PMID: 17673661
37. Gene silencing dramatically shortens daf-2 mutant longevity but less dramatically shorten daf-2 life span. PMID: 18006689
38. mutation of daf-12 marginally reduced life span in daf-2(+) hermaphrodites, as in plate-cultured populations, it did not in daf-2(+) males. PMID: 18056973
39. consolidate and extend our understanding of the complex genetics of daf-2 and its underlying molecular biology in Caenorhabditis elegans. PMID: 18245374
40. Hypoxia-mediated defects in nervous system development depended on signaling through the insulin-like receptor DAF-2, which serves to control the level of reactive oxygen species that also affects axon pathfinding. PMID: 18587389
41. Pathogen resistance of daf-2, akt-1, and akt-2 mutants is associated with restricted bacterial colonization, and daf-2 mutants are better able to clear an infection after challenge with Pseudomonas aeruginosa. PMID: 18782349
42. Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans. PMID: 18927620

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KEGG: cel:CELE_Y55D5A.5

STRING: 6239.Y55D5A.5a

UniGene: Cel.8775