Recombinant Mouse Actin, aortic smooth muscle (Acta2)

1. In murine myocardial infarction, infiltration of the infarct border zone with abundant a-SMA-positive myofibroblasts was associated with scar contraction. Isolated cardiac fibroblasts cultured in plates showed high a-SMA expression localized in stress fibers, exhibited activation of focal adhesion kinase (FAK), and synthesized large amounts of extracellular matrix proteins. PMID: 27825850
2. These data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an important determinant for some aspects of TGFbeta1-induced epithelial-mesenchymal transition via alphaSMA expression induction. PMID: 27194451
3. The level of alpha-SMA expression by intramuscular fibrogenic cells does not correlate positively with the level of collagen gene expression or the severity of skeletal muscle fibrosis in the mdx5cv mice. alpha-SMA is not a functional marker of fibrogenic cells in skeletal muscle fibrosis associated with muscular dystrophy PMID: 29320561
4. Data suggest that membrane-proximal signaling complexes constrained by AKAP220 impact the actin barrier dynamics and AQP2 trafficking to ensure water homeostasis. PMID: 27402760
5. Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA, and COL1a1 expression in a liver fibrosis disease model. PMID: 28467108
6. Disruption of smooth muscle Acta2 increases reactive oxygen species levels, activates NF-kappaB signaling and increases AngII receptor type I a expression. PMID: 28461455
7. The expression levels of alpha-smooth muscle actin (alpha-SMA, a marker of fibroblast activation) in fibrotic livers were significantly higher than those in control livers. PMID: 27538444
8. this study identifies Rac1 as a downstream target for SMA to inhibit smooth muscle cell proliferation and migration. PMID: 27176050
9. the coordinated up-regulations of desmin and alpha- actinin specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response. PMID: 26529187
10. site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta variants containing an R267A mutation exhibited reduced binding affinity for purine-ric... PMID: 27064749
11. Alpha-smooth muscle actin protein and mRNA are enhanced from brain blood vessels in an Alzheimer's disease animal model. PMID: 27463512
12. Astragaloside can delay the renal fibrosis process in diabetic mice by influencing the TGF-beta/SMADS signaling pathway and down-regulating TGF-beta1, SMAD2/3, and alpha-SMA expression. PMID: 26261569
13. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA during scleral chondrogenesis accompany myopia development. PMID: 25684979
14. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A. PMID: 25690651
15. Results suggest that the atypical motif asparaging-cysteine-systeine Asn(17)-Cys(18)-Cys(19) is crucial for the normal surface trafficking and function of hydroxycarboxylic acid receptor 2 protein hGPR109A. PMID: 25690654
16. The results suggest that the expression level of TGF-b1 and a-SMA in stromal fibroblasts may have prognostic significance in patients with clinical stage I-IIIA NSCLC after curative resection PMID: 24711139
17. alphaSMA is a useful marker for further understanding the molecular and cellular characteristics of non-hematopoietic cells in the lymph nodes. PMID: 24845380
18. This in vitro expression study revealed the additional profibrotic role of IL-6 in fibroblast to myofibroblast transition and in alpha smooth muscle actin induction. PMID: 23613464
19. Data indicate that NRG-1beta up-regulated the gene expressions of Nkx2.5, GATA4, alpha-actin, MLC-2v, and ANF in a time-dependent regulation of ErbB/ERK1/2 pathways. PMID: 23606057
20. these studies identify a pathway that culminates in the post-transcriptional regulation of utrophin A through increases in mRNA stability. PMID: 23591991
21. sustained Akt1-induced alphaSMA synthesis markedly decreased upon RNA silencing of SRF and myocardin. PMID: 24106278
22. This structural arrangement suggests that the cooperative assembly of the dimeric Purbeta repressor on the sense strand of the ACTA2 enhancer is dictated by the association of each subdomain with distinct purine-rich binding sites within the enhancer. PMID: 23724822
23. Smooth muscle alpha-actin is not necessary for myofibroblast formation and function and for wound closure, and smooth muscle gamma-actin and skeletal muscle alpha-actin may be able to functionally compensate for the lack of smooth muscle alpha-actin in myofibroblasts PMID: 23253249
24. It was found that binding between Porphyromonas gingivalis fimbriae and integrin alpha5beta1 on osteoblasts, and subsequent peripheral condensation of actin, are essential for entry of Porphyromonas gingivalis into osteoblasts. PMID: 23305098
25. Gefitinib offers protection against lung fibrosis induced by bleomycin in mice probably by inhibiting the downstream signals of EGFR and by downregulating the expression of alpha-SMA. PMID: 21177177
26. Monocytes and macrophages that express alpha actin preserve primitive hematopoietic cells in the bone marrow. PMID: 22983360
27. Scx and Id1 are involved in the BMP4-Smad1-SMA signal transduction pathway besides the TGFbeta1-Smad1-SMA signaling pathway and modulate phenotypic changes in MCs in diabetic nephropathy. PMID: 22474292
28. Data show that Acta2 deficient mice have a remarkable mammary phenotype such that dams lacking Acta2 are unable to nurse their offspring effectively. PMID: 22123032
29. expression in mammary myoepithelial cells has the functional consequence of enhancing contractile force generation required for milk ejection PMID: 21368298
30. Undifferentiating pericytes do not express alphaSMA. PMID: 21515289
31. Over expression of alpha-SMA in asthmatic lung tissue is closely related to the onset of asthma. GABAAR antagonist bicuculline could inhibit the expression of alpha-SMA. PMID: 20848783
32. alpha-SMA may be used as an effective indicator for the mid- and late stage incised wound of mice skin. PMID: 20225612
33. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments. PMID: 20630939
34. TGF-beta(1) increased the expression of alpha-SMA in BALB/c 3T3 fibroblasts and affected the Egr-1 protein expression during the early course of fibroblasts differentiation into myofibroblasts. PMID: 17651609
35. vascular smooth muscle alpha-actin gene transcription is regulated by purbeta PMID: 12874279
36. smooth muscle alpha-actin expression requires a transforming growth factor-beta control element PMID: 12970361
37. Interplay between Pur repressor isoforms and Sp1 and Smad coactivators may regulate alpha-actin enhancer output in TGFbeta1-activated myofibroblasts during episodes of wound repair and tissue remodeling. PMID: 15282343
38. The level of lung fibroblast alpha-smooth muscle actin (SMA) correlates with level of CCAAT/enhancer-binding protein beta isoform expression; SMA expression levels progressively decrease in cells from C/EBP beta wild-type to homozygous knockout mice. PMID: 15383601
39. Pur alpha and Pur beta repress smooth muscle alpha-actin gene transcription by means of DNA strand-selective cis-element binding and cell type-dependent protein-protein interactions PMID: 16436378
40. Smooth muscle alpha-actin suppresses the pro-fibrotic properties of myofibroblasts, highlighting the significance of smooth muscle-related proteins in moderating chronic organ fibrosis under pathological conditions. PMID: 17090535
41. In connective tissue fibroblasts, alpha-SMA is located within nuclear invaginations in close proximity to the nuclear membrane, but not in the nucleoplasm. PMID: 17310383
42. although both smooth muscle cells and myofibroblasts express smooth muscle alpha-actin, they use distinct transcriptional control mechanisms for regulating its expression PMID: 17823374
43. Activation of the normally silent SM alpha A gene in reprogrammed adult cardiomyocytes is linked to elevated interaction of serum response factor with Pur-alpha/Pur-beta. PMID: 18344281
44. Barx2 cooperates with other muscle-expressed transcription factors to regulate the early cytoskeletal remodeling events that underlie efficient myoblast differentiation. PMID: 19269978
45. These findings indicate the existence of alpha-smooth muscle actin-positive endothelial cells in adult aortic endothelium and the possible association with progression of atherosclerosis. PMID: 19285011
46. Study uncovers a strong reciprocal interdependence between Nck and PI(4,5)P(2) in promoting localized N-WASp-mediated actin polymerization in cells. PMID: 19917259

Show More

Hide All

KEGG: mmu:11475

STRING: 10090.ENSMUSP00000048218

UniGene: Mm.213025