Recombinant Mouse Alpha-defensin 1(Defa1)

Code CSB-YP006652MO
Size US$1916
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names Defa1
Uniprot No. P11477
Research Area Immunology
Alternative Names Defa1; Defcr; Defcr1Alpha-defensin 1; Cryptdin-1; Defensin-related cryptdin peptide
Species Mus musculus (Mouse)
Source Yeast
Expression Region 59-93aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 31.1kDa
Protein Length Full Length of Mature Protein
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium.
Gene References into Functions
  1. Mouse adenovirus 2 infection was enhanced by enteric alpha-defensins. PMID: 28622386
  2. Decreased alpha-defensin is associated with intestinal inflammation in a model of inflammatory bowel disease. PMID: 20222124
  3. cryptdin-1 and cryptdin-4 exhibit circadian oscillation PMID: 16129697
  4. the Arg5-Glu13 salt bridge in alpha-defensin is conserved for defensin in vivo stability PMID: 16246847
  5. MMP-7 activates mouse paneth cell pro-alpha-defensins PMID: 16822871

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Subcellular Location Secreted
Protein Families Alpha-defensin family
Tissue Specificity Paneth cells of the small bowel.
Database Links

KEGG: mmu:13216

UniGene: Mm.425522

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