Recombinant Mouse Autoimmune regulator (Aire)

1. The Aire fl/fl strain is a suitable model to scrutinize the cell specific function of Aire in distinct biological processes. Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Aire was also shown to be expressed in cells of hematopietic and reproductive lineages. PMID: 29193031
2. Aire associates with spindle-associated proteins in mouse embryonic stem cells. Loss of function analysis revealed that Aire was important for centrosome number regulation and spindle pole integrity specifically in mouse embryonic stem cells. PMID: 28742026
3. allelic variants of one AIRE SNP may differentially shape the melanoma antigen-specific T cell repertoire potentially influencing susceptibility to melanoma PMID: 27563821
4. In an insulin-promoter model, lack of Aire in medullary thymic epithelial cells, but not in BM-derived APCs, impaired clonal deletion and Treg production. In an Aire-promoter Tg model, both mTECs and BM-derived APCs independently induced clonal deletion without Aire. Treg production was impaired by the lack of Aire in mTECs, but not in BM-derived APCs, suggesting an essential but not universal role for Aire in tolerance. PMID: 29101311
5. the maternal microbiome influences Treg differentiation in the thymus of offspring through GPR41-mediated Aire expression PMID: 29021375
6. A mutation in LYN, an inhibitory protein tyrosine kinase that is implicated in systemic autoimmunity, combines with an Aire mutation to provoke organ-specific autoimmunity. PMID: 27571405
7. Aire exerts multi-faceted autoimmune control that extends to a population of innate-like T cells. PMID: 27851927
8. this study shows that Aire enforces immune tolerance by ensuring that distinct autoreactive T cell specificities differentiate into the Treg cell lineage PMID: 27130899
9. This finding is the first direct evidence that Aire also plays a role in controlling medullary thymic epithelial cells-thymocyte adhesion. PMID: 27505711
10. findings identified two novel stages in the differentiation program of Aire(+) Medullary thymic epithelial cells. PMID: 27401343
11. this study shows that Aire and some of its partners, notably those implicated in the DNA-damage response, preferentially localize to and activate long chromatin stretches that are overloaded with transcriptional regulators, known as super-enhancers PMID: 28135252
12. Results indicated that AIRE influenced gene expression in germ cell 1 spermatogonial (GC1-spg) cells by acting at multiple levels, including transcription, translation, RNA processing, protein transport, protein localization, and protein degradation, thus setting the foundation in understanding the functional role of AIRE in germ cell biology. PMID: 27281783
13. this study provides insight into the complex molecular mechanisms that control the medullary thymic epithelial cells-specific expression of Aire PMID: 27941786
14. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398
15. we found that Aire up-regulated TLR3 expression and modulated the downstream cytokine expression and nuclear factor-kappaB (NF-kappaB) of the TLR3 signaling pathway. PMID: 27916941
16. Aire-expressing dendritic cells inhibited TCR signaling pathways and decreased quantity of CD4+IFN-gamma+ autoreactive T cells. Aire plays role in maintenance of peripheral immune tolerance. PMID: 26729097
17. Aire may have a role in inducing Th1 and Th17 differentiation by upregulating cytokine expression in dendritic cells. PMID: 26548750
18. androgen control of an intrathymic Aire-mediated tolerance mechanism contributes to gender differences in autoimmunity. PMID: 27072778
19. results indicate that in females, estrogen induces epigenetic changes in the AIRE gene, leading to reduced AIRE expression under a threshold that increases female susceptibility to autoimmune diseases. PMID: 26999605
20. Our results identify Aire as an important regulator of peripheral T cell homeostasis in gastrointestinal tissues. Given a suitable trigger the absence of peripheral Aire leads to dysregulated T cell proliferation and disease. PMID: 26112418
21. Data indicate a highly conserved noncoding DNA element that is essential for Autoimmune regulator (Aire) gene expression. PMID: 26527800
22. Aire's unique property of generating a self-tolerant T cell repertoire is functional only in medullary thymic epithelial cells. PMID: 26453754
23. Molecular characterization of the functional domains of Aire has revealed multiple binding partners that assist Aire's function in altering gene transcription and chromatin remodeling. PMID: 26579596
24. Aire expression in thymic epithelial cells was decreased in germ-free mice without commensal bacteria. PMID: 25157574
25. Aire's collaboration with the bromodomain-containing protein, Brd4, uncovered correspondence between those genes induced by Aire and those inhibited by a small-molecule bromodomain blocker. PMID: 26216992
26. Aire increased the diversity of the thymic epithelial cell transcriptome and seemed to target genes expressed in a minority of cells, and increased expression of its target genes. PMID: 26237550
27. Data indicate that keratin 17 (k17) regulates autoimmune regulator Aire to promote skin tumorigenesis. PMID: 26168014
28. Data show that sirtuin 1 (Sirt-1) mediated deacetylation of Aire protein was required for the transcriptional-transactivational potential of Aire. PMID: 26006015
29. AIRE-dependent versus AIRE-independent tissue-restricted antigens project nonredundant representations of peripheral tissues in the thymus. PMID: 26034170
30. expressed in thymic but not peripheral B cells PMID: 26070482
31. subfertility in Aire(-/-) mice is dependent on a functional adaptive immune system thus confirming its autoimmune aetiology. PMID: 25689230
32. Aire promotes the perinatal generation of a distinct compartment of Foxp3(+)CD4(+) regulatory T (Treg) cells, which stably persists in adult mice. PMID: 25791085
33. The results reveal a cooperation between medullary thymic epithelial cells and CD8alpha+ dendritic cells for presentation of Aire-induced self-antigens to developing thymocytes. PMID: 25220213
34. Results indicate the roles of Aire in the differentiation program of medullary thymic epithelial cells (AEL-mTECs). PMID: 24516201
35. Aire-containing complexes include 7SK RNA, the latter interaction disrupted by HNRNPL knockdown, suggesting that HNRNPL may partake in delivering inactive P-TEFb to Aire PMID: 24434558
36. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance PMID: 24464130
37. There is an age-related association between Aire and regulatory T cells (Tregs) in the susceptibility to experimental autoimmune encephalomyelitis. PMID: 23849800
38. These findings add to the understanding of how specific DC subtypes regulate the early responses during T cell-dependent antibody responses within the spleen and further define the role of AIRE in the periphery as regulator of self-antigen expression and lymphocyte migration. PMID: 23265639
39. Aire can facilitate early chondrocyte differentiation by expression of Bmp2 through altering the histone modification status of the promoter region of Bmp2. PMID: 23850677
40. These findings reveal a mutual interdependence of miRNA and Aire in the regulation of promiscuous gene expression in purified mouse and human thymic epithelial cells PMID: 23589212
41. Aire can play a role as a controller of transcription of miRNAs located within genomic regions encompassing ORF and/or mRNA genes. PMID: 22883565
42. Aire deficiency promotes TRP-1-specific immune rejection of melanoma. PMID: 23370329
43. Blockade of B7-1/B7-2 in NOD.AireGW/+ mice results in fulminant, early-onset autoimmune peripheral neuropathy. PMID: 23487421
44. transcriptional activity determines expression profile of peripheral tissue antigen genes in medullary thymic epithelial cells PMID: 22564670
45. [review] The autoimmune regulator Aire is a critical transcription factor for generating central tolerance in the thymus and is highly conserved between human and mouse AIRE proteins. PMID: 23456700
46. Data indicate that Aire requires its PHD2 domain to effectively impose immunological tolerance. PMID: 23319629
47. These results indicate a unique DNA methylation profile that is independent of Aire in medullary thymic epithelial cells. PMID: 23116172
48. These findings suggest that the capacity of Aire to regulate expression of a huge array of tissue-restricted antigens relies solely on an unconventional transcriptional mechanism, without intermediary transcription factors. PMID: 23041971
49. Aire-mediated expression of peripheral tissue antigens drives the thymic development of a subset of organ-specific T(regs), which are likely coopted by tumors developing within the associated organ. PMID: 23471412
50. Aire promotes the self-renewal of embryonic stem cells through the activation of Lin28 and the inhibition of the let-7 microRNA family. PMID: 22540148

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KEGG: mmu:11634

STRING: 10090.ENSMUSP00000114904

UniGene: Mm.35300