Recombinant Mouse Beta-1 adrenergic receptor(Adrb1),partial

Code CSB-YP001391MO1
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Source Yeast
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Code CSB-EP001391MO1
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Source E.coli
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Code CSB-EP001391MO1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001391MO1
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Source Baculovirus
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Code CSB-MP001391MO1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adrb1
Uniprot No. P34971
Alternative Names Adrb1; Adrb1rBeta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity).
Gene References into Functions
  1. Cardiac specific expression of the mutated Cav1.2PKA_P2(-/-) gene reduces Cav1.2 alpha1c protein concentration, calcium current (ICa), and the beta-adrenergic stimulation of L-type ICa in cardiomyocytes. PMID: 28778765
  2. Proliferation in cardiac fibroblasts induced by beta1-adrenoceptor autoantibody results in endomyocardial fibrosis. PMID: 27577254
  3. the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins. PMID: 28487987
  4. ghrelin has a critical role in preventing hypoglycemia and promoting survival during severe caloric restriction, a process that requires cell-expressed beta1AR PMID: 27548523
  5. knocking out of the beta1/2 receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25. PMID: 27978539
  6. Computer simulations model the responses to moderate stimulation/inhibition of the beta1-adrenergic signaling system and its components in mouse ventricular myocytes. PMID: 26936457
  7. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure. PMID: 26796036
  8. Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy. PMID: 26464333
  9. Knockout of the C5aR1 attenuated the effect of beta1-AR in the heart, suggesting an association between the beta1-AR and C5aR1, although further investigation is required to determine if this is a direct or causal association PMID: 26727203
  10. The beta1-AR may play an important role in the development of atrial fibrillation. PMID: 26203906
  11. Partial gap junction uncoupling increased propensity and amplitude of Ca(2+) alternans, and made them more sensitive to reversal by beta-AR activation, as in isolated myocytes. PMID: 25828762
  12. These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response. PMID: 25944088
  13. Myocardial adrenergic receptor beta 1 preferentially associates with AC5. PMID: 25677623
  14. role of beta-ARs in early muscle regeneration PMID: 25000590
  15. Phosphorylation of beta1-AR by PKA stimulates active Ca(2+)influx through TRPV5. PMID: 24828496
  16. Sustained beta1-adrenoceptor activation in the diseased heart exacerbates left ventricular remodelling and therefore may promote disease progression from compensatory hypertrophy to heart failure PMID: 23750586
  17. This study report that both beta1- and beta2-ARs are expressed in a majority of GABAergic interneurons in the medial prefrontal cortex of mice. PMID: 24215978
  18. Calcium {Ca(2+)} entry through beta-adrenergic-stimulated LTCC underlies hypoxia-induced [Ca(2+)]i overload and the ensuing loss of mitochondrial function in intact heart. PMID: 24041537
  19. Data indicate that ischemic injury coupled to G protein-coupled receptor beta1/2 adrenergic receptors activation required GRK2 (GPCR kinase 2) activation. PMID: 24170934
  20. Our findings indicate a novel function for beta1AR-mediated beta-arrestin1 signaling activated by carvedilol in miR biogenesis. PMID: 24334028
  21. a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells. PMID: 24121510
  22. beta1-adrenergic receptor recycles via a membranous organelle, recycling endosome, by binding with sorting nexin27. PMID: 23780416
  23. We demonstrate that restoration of cardiac plasma membrane levels of S1PR1 produces beneficial effects that counterbalance the deleterious beta1AR overstimulation in heart failure. PMID: 23969695
  24. Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR endocytic responses. PMID: 23965992
  25. CREB-binding protein (CBP) regulates beta-adrenoceptor (beta-AR)-mediated apoptosis. PMID: 23579242
  26. TNFalpha-induced betaAR desensitization is mediated by GRK2 and is independent of Gbetagamma, uncovering a hitherto unknown cross-talk between TNFalpha and betaAR function, providing the underpinnings of inflammation-mediated cardiac dysfunction. PMID: 23785004
  27. Adrb1 activates Epac2 to induce sarcoplasmic reticulum calcium leakage via a pathway that contributes to arrhythmia and reduced cardiac function. PMID: 23363625
  28. In muscararinic M2 receptor knockout mice,heart function is not much affected; as possible mechanisms of this normal cardiac function, decreases of gene expression and receptor binding of beta1- and beta2-adrenoceptors should be considered PMID: 23093370
  29. A potential cooperative role for beta(1) and beta(2) adrenergic receptors in stress-induced reinstatement. PMID: 22593095
  30. The beta(1) signaling pathway mediates most of the sympathetic nervous system stimulation of adaptive thermogenesis. PMID: 22728333
  31. beta1- and beta2-adrenergic signaling exert opposite effects on bone- beta1 exerting a predominant anabolic stimulus in response to mechanical stimulation and during growth, whereas beta2-adrenergic receptor signaling mainly regulates bone resorption during aging. PMID: 22407956
  32. Data show that overexpression of beta1- and beta2-adrenergic receptors in hepatocytes from young mice and rats increased cellular lipid content. PMID: 22457517
  33. Norepinephrine regulates intestinal mucosal immune responses mediated by intestinal intraepithelial lymphocytes via beta adrenoreceptors. PMID: 22398028
  34. Induction of Fos by ssadrenergic signaling is critical for the full activation of CA1 pyramidal neurons in response to excitatory input from CA3 pyramidal neurons conveying retrieved contextual information. PMID: 21377513
  35. beta-Adrenergic receptor-PI3K signaling crosstalk in mouse heart PMID: 22028912
  36. Confinement of beta 1- and beta 2-adrenergic receptors in the plasma membrane of cardiomyocytes is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins PMID: 21680711
  37. High (stress) levels of epinephrine directly compromise the activity of neonatal mouse skin fibroblasts through the activation of beta1-, beta2- and beta3-adrenoceptors, but not through alpha1- and alpha2-adrenoceptors. PMID: 21366703
  38. renin expression was found to be significantly lower at all developmental stages in the kidneys of adrenergic beta(1)/beta(2) knockout mice PMID: 21389089
  39. b1-adrenoceptors are the predominant b-adrenoceptor in mouse astrocytes and are primarily responsible for cAMP production in response to b-adrenoceptor stimulation PMID: 21138422
  40. negative inotropy and heart hypertrophy occur in total adrenergic beta receptor deficiency PMID: 20406048
  41. Results suggest that catecholamines induce myocyte necrosis primarily through beta(1)-AR-mediated increases in L-type calcium channel activity, but other mechanisms are also involved in rodents. PMID: 20495143
  42. the unique signaling effects of enhanced beta(2)AR and AC5, which have the potential to afford benefit in heart failure, failed to salvage ventricular function in beta(1)AR-mediated cardiomyopathy. PMID: 20443853
  43. beta-Adrenergic receptors transmit sympathetic signals to the ion secretory elements of the colonic epithelial cells stimulating a transient Cl ion secretion and a sustained K ion secretion. PMID: 20413718
  44. This work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart. PMID: 19945464
  45. [beta]1-AR play a significant role in regulating LPS-mediated mortality and inflammation. PMID: 19333138
  46. vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse PMID: 12006674
  47. Pathogenesis of DCM in CREB(A133) mice does not appear to involve abnormal betaAR signaling PMID: 12054854
  48. modulates receptor trafficking and signaling in cardiac myocytes PMID: 12097326
  49. betaAR signaling required for diet-induced thermogenesis and obesity resistance. PMID: 12161655
  50. role in obesity and cold sensitivity and response to fasting PMID: 12387862

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Subcellular Location Cell membrane, Multi-pass membrane protein, Early endosome
Protein Families G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB1 sub-subfamily
Database Links

KEGG: mmu:11554

STRING: 10090.ENSMUSP00000040847

UniGene: Mm.46797

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