Recombinant Mouse Bombesin receptor subtype-3 (Brs3), partial

Code CSB-YP002820MO1
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Source Yeast
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Code CSB-EP002820MO1
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Source E.coli
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Code CSB-EP002820MO1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002820MO1
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Source Baculovirus
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Code CSB-MP002820MO1
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Brs3
Uniprot No.
Alternative Names
Brs3; Bombesin receptor subtype-3; BRS-3
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Gene References into Functions
  1. Data suggest that the failure to detect an existing endogenous bombesin-like receptor 3 (BRS-3) ligand in the parabiotic mice could be due to limited cross-circulation and a ligand's short half-life. PMID: 26562312
  2. Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination. PMID: 24326363
  3. Data from knockout mice suggest that Brs3 involvement in regulation of body temperature is via a central mechanism, upstream of sympathetic efferent pathways to stimulate brown adipose tissue. PMID: 24452453
  4. This sstudy demonistrated comprehensive mapping of BRS-3 mRNA in the mouse brain and double in situ hybridization was performed to determine whether BRS-3 colocalizes with other neurotransmitters or neuropeptides. PMID: 22911445
  5. Data suggest that the bombesin receptor subtype-3 agonist indirectly inhibited orexin neurons through GABAergic input and directly activated orexin neurons. PMID: 20467915
  6. BRS-3-deficient mice remained longer in the open arms of the maze. Analyses of risk assessment behavior revealed that BRS-3-deficient mice exhibited increased 'stretched attend posture' behavior in both the L-D box and elevated plus maze tests. PMID: 11803457
  7. BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days for lungs PMID: 12959933
  8. BRS-3 gene deletion upsets the mechanism by which leptin decreases the expression of MCH-R. PMID: 14988239
  9. Hyperphagia is a major factor leading to increased body weight and hyperinsulinemia in BRS-3 KO mice. PMID: 18039774

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Database Links
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