BRS3

BRS3 encodes bombesin receptor subtype-3, a G protein-coupled receptor (GPCR) with limited homology to other bombesin receptors. Also known as BB3R, it lacks high-affinity binding for canonical bombesin peptides, suggesting distinct ligand specificity. Its activation modulates intracellular calcium signaling and MAPK pathways, though endogenous ligands remain incompletely characterized.
BRS3 is linked to metabolic regulation, with roles in energy homeostasis and glucose metabolism. Aberrant expression may contribute to obesity and type 2 diabetes, while emerging evidence implicates it in certain cancers. Drug development focuses on selective agonists/antagonists to target metabolic disorders, with preclinical studies exploring therapeutic potential in metabolic syndrome and obesity management.