Recombinant Mouse Caspase-6 (Casp6)

1. Intact motor axons of Casp6 null mice had normal electrophysiological properties but, as tested serially during axonal degeneration (AxD), there was attenuated loss of excitability. Following transection, morphological features of AxD were evident in both wild type and Casp6-/- mice but the latter had evidence of slowed progression. PMID: 29229552
2. Caspase-6 is posttranslationally palmitoylated by the palmitoyl acyltransferase HIP14 and that the palmitoylation of Caspase-6 inhibits its activation. PMID: 27911442
3. The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b gene, known to be detrimental in murine melioidosis. Expression of the IL-10 gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 rendered mice more susceptible against B. pseudomallei challenge PMID: 28686630
4. caspase-6 could regulate breast cancer cell invasion by modulating MMP-2 and MMP-9 expression in 4T1 tumor-associated macrophages PMID: 27325699
5. Casp6 is unlikely to be involved in colitis-associated tumors. PMID: 25470254
6. p53 activity is an important upstream regulator of caspase-6 activity in muscle tissue. PMID: 24070868
7. TNFalpha-induced RIP1-independent caspase-6 activation was involved in regulating the relationship between autophagy and necroptosis. PMID: 23941769
8. CASP6 released from axonal terminals regulates microglial TNF-alpha secretion, synaptic plasticity, and inflammatory pain. PMID: 24531553
9. Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume. PMID: 22262731
10. This study demonistrated that elimination of caspase-6 protein and activity in the BACHD mouse model does not prevent the production of a 586 aa Htt proteolytic fragment in the brain. PMID: 22649225
11. Neutrophil/macrophage contact activates CASP-6, producing interleukin-1 receptor-associated kinase-M (IRAK-M) cleavage and de-repression of alveolar macrophages; CASP-6 deletion protects mice from death caused by bacterial peritonitis. PMID: 21098228
12. Lamin A/C and caspase-6 could be valuable tools in the knowledge of oocyte in vitro destiny PMID: 20130288
13. p53 activation enhances XIAP inhibition-induced cell death by promoting mitochondrial release of second mitochondria-derived activator of caspases (SMAC) and by inducing the expression of caspase-6. PMID: 19897582
14. CREB-binding proteins are specifically targeted by caspases and calpains at the onset of neuronal apoptosis PMID: 14657026
15. caspase-6 and caspase-7 are activated by teratogens in early postimplantation mouse embryos PMID: 14686614
16. Taken together, these results suggest that activation of caspases (6 and 7) and the subsequent cleavage of lamin A/C and PARP are involved in the morphological changes of apoptotic macrophages infected with Actinobacillus actinomycetemcomitans. PMID: 17893180
17. Casp6 may regulate both B cell activation and differentiation PMID: 18981099
18. results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease PMID: 19225519

Show More

Hide All

KEGG: mmu:12368

STRING: 10090.ENSMUSP00000029626

UniGene: Mm.281379