Recombinant Mouse Cytochrome P450 1B1 (Cyp1b1)

1. Hepc decreases in Cyp1b1-/- and gestational vitamin A deficiency mice resulted in stellate activation and lipogenesis suppression. PMID: 28583802
2. Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, the study tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. hCYP1B1 genotype did not impact lung tumor multiplicity, but tended to enhance incidence compared to Cyp1b1 wild-type mice (P = 0.07). PMID: 26990437
3. CYP1B1 contributed to the development of Ang II-induced abdominal aortic aneurysm and associated pathogenic events in mice, likely by enhancing oxidative stress and associated signaling events PMID: 27301358
4. Miroestrol suppressed beta-naphthoflavone increases in CYP1B1. PMID: 26893163
5. Findings provide evidence that CYP1B1 is directly involved in the development of cardiac hypertrophy. PMID: 28251434
6. Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha and PPARalpha. PMID: 27036855
7. hypertension, and associated pathogenesis in ApoE(-/-)/Cyp1b1(+/+) mice on an atherogenic diet are most likely dependent on CYP1B1-generated oxidative stress and increased plasma lipid levels independent of blood pressure and absorption of lipids. PMID: 26573711
8. Follicle stimulating hormone functions via p38 MAPK-induced dephosphorylation at Ser(727) of STAT1 to downregulate Cyp1b1 expression and maintain the estradiol levels in mouse dominant follicles. PMID: 25315223
9. Cyp1b1 contributes to angiotensin II induced hypertension and its pathogenesis in male mice. PMID: 25870196
10. Suggest that Cyp1b1 plays a critical role in female mice in protecting against renal dysfunction and end-organ damage associated with ANG II-induced hypertension. PMID: 25694484
11. Data indicaate that adduct formation in cytochrome P450 Cyp1b1 knockout mice was significantly reduced compared to wild-type mice receiving dibenzo[def,p]chrysene (DBC). PMID: 25868132
12. Cyp1b1 deletion substantially alters the expression of genes associated with fatty acid homeostasis PMID: 25703193
13. Data indicate that hepatic stearoyl-CoA desaturase 1 (SCD1) expression was decreased in cytochrome P450 1B1 (CYP1B1)-null mice. PMID: 24684199
14. Using inhibitors of p38 and MSKs, as well as mouse embryonic cells derived from p38alpha-deficient and MSK1/2 double knockout mice, we show here that TNF-alpha potentiates CYP1B1 upregulation via the p38/MSK1 kinase cascade PMID: 25233930
15. a direct role for mitochondrial CYP1B1 in PAH-mediated oxidative and chemical damage to mitochondria. PMID: 24497629
16. Cyp1B1 expression in vascular cells plays an important role in the regulation of the cellular reductive state, thrombospondin (TSP)2 expression, and NF-kappaB activation. PMID: 24088896
17. Metabolic activity of CYP1B1 contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of Postn expression. PMID: 23979599
18. In the present study we show that [a] NQO1 protein locates to cytosol, ER and mitochondria. PMID: 23692925
19. important role for Cyp1B1 expression in the regulation of pericyte proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappaB expression and/or activity PMID: 23568032
20. Dexamethasone in combination with methylisobutylxanthine (DM) induces Cyp1b1 and a 6.7 kb mouse Cyp1b1 promoter-luciferase reporter in each cell type prior to adipogenesis. An 18 base sequence (at -6.11 kb) (PaxE) which was essential for this reporter stimulation in 3T3-L1 cells bound the transcription factor Pax6. PMID: 23376040
21. in DOCA-salt hypertension in mice, cytochrome P450 1B1 plays a pivotal role in cardiovascular dysfunction, renal damage, and inflammation, and increased levels of catecholamines, vasopressin, and endothelin-1 PMID: 23108654
22. CYP1B1-mediated estrogen metabolism promotes the development of pulmonary arterial hypertension, likely via the formation of mitogens, including 16alpha-hydroxyestrone. PMID: 22859684
23. Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice. PMID: 22184325
24. The results indicate that downregulation of testicular CYP1B1 by estradiol was independent of PKA activity and was not mediated by estrogen receptors in MA-10 cells. PMID: 21785971
25. results identify protein kinase A as the major signaling pathway involved in the LH-mediated regulation of testicular CYP1B1 expression in Leydig tumor cells PMID: 21389345
26. CYP1B1 gene plays an important role in the development of the anterior chamber angle. Deletion of this gene leads to abnormalities in the trabecular meshwork. PMID: 18953896
27. Data suggest that cytochrome P450 1B1 contributes to angiotensin II-induced hypertension and associated pathophysiological changes. PMID: 20805442
28. CYP1B1 and eNOS cooperate in different ways to lower oxidative stress and thereby to promote capillary morphogenesis in vitro and angiogenesis in vivo. PMID: 20032512
29. CYP1A1 polymorphisms probably predispose to an earlier onset of breast cancer and might be associated with higher c-erbB-2 protein level, but further studies on a much larger group are required to substantiate our findings. PMID: 20088394
30. CYP1B1-deficient mice exhibit abnormalities in their ocular drainage structure and trabecular meshwork that are similar to those reported in human PCG patients [review] PMID: 17914928
31. Cyp1b1 bioactivation of dibenzo(a,1)pyrene occurs in fetal target tissues, following transplacental exposure, with the thymus and lung as primary and secondary targets, respectively. PMID: 19138945
32. In the developing mouse embryo Cyp1b1 exhibits asymmetric expression along the axes of development. PMID: 15359218

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KEGG: mmu:13078

STRING: 10090.ENSMUSP00000024894

UniGene: Mm.214016