CYP1B1

CYP1B1, also known as Cytochrome P450 Family 1B Member 1, is a heme-thiolate monooxygenase involved in the metabolism of various xenobiotics and endogenous compounds. It plays a crucial role in the regulation of signaling molecules and hormone metabolism. CYP1B1 is expressed in various tissues, including liver, lung, colon, eye, and kidney, and is involved in the metabolism of steroids, fatty acids, melatonin, and vitamins. It contributes to the activation of environmental carcinogens and is associated with tumor development and metabolic diseases such as obesity, hypertension, and atherosclerosis. Research on CYP1B1 inhibitors has led to potential therapeutic targets for cancer and metabolic disorders.
CYP1B1 functions in multiple signaling pathways, including those involving peroxisome proliferator-activated receptors (PPARs), estrogen receptor (ER), and retinoic acid receptors (RARs). Its dysregulation is linked to various diseases, including cancer, glaucoma, and metabolic diseases. Current drug development efforts are focused on identifying CYP1B1 inhibitors that can modulate its activity and potentially treat related diseases.