Recombinant Mouse Dynamin-1-like protein (Dnm1l)

1. Authors found a fragmentation of mitochondria due to an increase in mitochondrial fission associated with an up-regulation of dynamin-related protein 1 (Drp1), and a decrease in mitochondrial fusion associated with a down-regulation of mitofusin 2 (Mnf2) and increased proteolysis of optic atrophy 1 (Opa1). PMID: 28939434
2. These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly. PMID: 29575122
3. the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1), which phosphorylates Drp1 at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes. PMID: 29654945
4. his study demonstrates that inhibition of Drp1 hyperactivation by a Drp1 peptide inhibitor P110 is neuroprotective in a MPTP animal model. Our data also suggest that the protective effects of P110 treatment might be mediated by inhibiting the p53 mediated apoptotic pathways in neurons through inhibition of Drp1-dependent p53 mitochondrial translocation. PMID: 27619562
5. Drp1 phosphorylation mediated by c-Abl is required for oxidative stress-induced cell death in primary cortical neurons. PMID: 29022905
6. Our work unraveled a novel function for cofilin1-dependent actin dynamics in mitochondrial fission, and identified cofilin1 as a negative regulator of mitochondrial DRP1 activity PMID: 28981113
7. Chrysophanol inhibited the LPS-induced production of proinflammatory mediators and cytokines via suppression of mitogen-activated protein kinase/nuclear factor kappa-B activation and reactive oxygen species generation. In addition, chrysophanol downregulated LPS-induced mitochondrial fission by diminishing dynamin-related protein 1 (Drp1) dephosphorylation. PMID: 28703078
8. Results uncovered a novel mechanism of Drp1-mediated mitochondrial fragmentation in senecionine-induced liver injury. PMID: 28282614
9. Mitophagy and mitochondrial spheroid formation are induced by Drp1-deficiency, resulting in fission impairment. PMID: 28324645
10. that laforin and malin are novel regulators of mitochondrial quality control pathway and that the mitochondrial dysfunction resulting from the increased Drp1 levels could underlie neuropathology in Lafora disease PMID: 28063983
11. In organ cultures of the first molar, tooth germ developed to the early bell stage. The amount of dentin formed under DRP1 inhibition was significantly larger than that of the control. PMID: 29223396
12. Found that X-irradiation triggered Drp1 phosphorylation at serine 616 (S616) but not at serine 637 (S637). Reconstitution analysis revealed that introduction of wild-type (WT) Drp1 recovered radiation-induced mitochondrial fission, which was absent in Drp1-deficient cells. PMID: 29217195
13. Findings suggest that a partial reduction of Drp1 decreases the production of phosphorylated Tau, reduces mitochondrial dysfunction, and maintains mitochondrial dynamics, enhances mitochondrial biogenesis and synaptic activity in Tau mice. PMID: 28173111
14. The Drp1 might play a significant role in lamellipodia formation and cell spreading through a different mechanism from that used for regulating mitochondrial dynamics/function. PMID: 28314909
15. The structure and function of Dnm1l protein in mitochondrial fission is reviewed. PMID: 28132464
16. screening a panel of proteins that regulate mitochondrial morphology in bella GCs revealed de-regulation of phospho-Drp1(Ser616), a key mitochondrial fission regulatory factor. Our data provide new insights into the function of Oxr1, revealing that specific isoforms of this novel antioxidant protein are associated with mitochondria. PMID: 27036366
17. PRKAA deletion promoted mitochondrial fragmentation in vascular endothelial cells by inhibiting the autophagy-dependent degradation of DNM1L. PMID: 28085543
18. hepatic stimulator substance could regulate mitochondrial fission and hepatocyte apoptosis during liver ischemia/reperfusion injury by orchestrating the translocation and activation of Drp1 PMID: 28646508
19. Expression of the fission protein DRP1 was increased in the brains of old exercised mice. Exercise training in old mice can improve brain mitochondrial function through effects on electron transport chain function and mitochondrial dynamics without increasing mitochondrial biogenesis. PMID: 28108329
20. Pharmacological inhibition of Drp1 prevents mitochondrial fission and reduces myocardial ischemia-reperfusion injury in diabetic mice. PMID: 28173848
21. Report a novel non-canonical function of the fission protein, DRP1 in maintaining or positively stimulating mitochondrial respiration, bioenergetics and ROS signalling in adult cardiomyocyte, which is likely independent of morphological changes. PMID: 27794519
22. Podocyte apoptosis induced by hyperglycemia can be reversed by polydatin through suppressing Drp1 expression. PMID: 28383775
23. Heat acclimation and heat shock cause changes in mitochondrial morphology of muscle cells by acting on Drp1, which results in favoring mitochondrial fusion and fission, respectively. PMID: 27730652
24. findings provide new insights into the role of the Drp1-dependent mitochondrial pathway in the osteogenic dysfunction during inflammation, indicating that this pathway may be a target for the development of new therapeutic approaches for the prevention and treatment of inflammation-induced bone destruction PMID: 28388678
25. Drp1 binds a mitochondrial enzyme that produces phosphatidic acid, MitoPLD, and regulates mitochondrial division. PMID: 27635761
26. Loss of Rip3 significantly delays the degeneration of Drp1-KO Purkinje neurons. Rip3 loss also helps Drp1-KO Purkinje cells maintain the elongated morphology of the mitochondrial tubules. PMID: 27640145
27. Drp1 does not control insulin secretion via its effect on proton leak but instead via modulation of glucose-fueled respiration. PMID: 28174288
28. These results suggest that neuropathology and combined cognitive decline can be attributed to hyperactivation of Drp1 in the pathogenesis of AD. Therefore, inhibitors of excessive mitochondrial fission, such as Drp1 inhibitors, may be a new strategy for AD. PMID: 28432138
29. MiD51 can suppress Mff-dependent enhancement of Drp1 GTPase activity. PMID: 27076521
30. These findings may have implications for the development of Drp1 based therapeutics for Alzheimer's disease patients. PMID: 27677309
31. these data unmasked a role for mitochondrial fission in leptin sensitivity and glucose sensing of POMC neurons. PMID: 28190775
32. Our results provide a molecular explanation for the contribution of Drp1 to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO-Parkin pathway may be a novel therapeutic target to treat PD PMID: 27267045
33. The data of this study demonstrated that dynamin 1 is required for the formation, functional maturation, and subsequent survival of the calyx of Held. PMID: 27251629
34. This study reveals an essential role of SUMOylated FADD in Drp1- and caspase-10-dependent necrosis. PMID: 27799292
35. sustained phosphorylation of Akt by Abeta directly activates Drp1 and inhibits autophagy through the mTOR pathway. Together, these changes elicit abundant mitochondrial fragmentation resulting in ROS-mediated neuronal apoptosis. PMID: 27599716
36. Thus, Drp1-linked excessive mitochondrial fission contributed to VMC and midivi1 may be a potential therapeutic approach. PMID: 28131843
37. In the absence of Drp1, connected mitochondria transiently depolarize. The transient depolarization is independent of calcium signaling and uncoupling protein 2. PMID: 27181353
38. Parkin protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1. PMID: 27597885
39. knockdown of Mfn2 in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 during chondrogenesis resulted in a loss of differentiation ability PMID: 26638184
40. Drp1 regulates mitochondrial transport in growing dendrites of Purkinje cells and is required for dendritic arborization. PMID: 26689905
41. Mff cannot bind to assembly-deficient mutants of Drp1, suggesting that Mff selectively interacts with higher-order complexes of Drp1. PMID: 26446846
42. Loss of Drp1 compromises the intrinsic bioenergetic function of axonal mitochondria, thus revealing a mechanism by which disrupting mitochondrial dynamics can cause dysfunction of axons. PMID: 25880092
43. Drp1 is required for functionally active mitochondria, and supplementing with ATP can restore the defects induced by Drp1 suppression. PMID: 26514444
44. These findings strongly suggest that Drp1 plays an important role in determining the fate of cells after irradiation via the regulation of mitochondrial dynamics. PMID: 26466676
45. our in vivo observations clarify the role of mitochondrial fission in neurons, demonstrating that Drp1 ablation in adult forebrain neurons compromises critical neuronal functions without causing overt neurodegeneration. PMID: 25909888
46. enhanced ERK signaling in Drp1-knockdown macrophages is implicated in the potentiation of NLRP3 inflammasome activation, via mediating mitochondrial localization of NLRP3 to facilitate the assembly of NLRP3 inflammasome PMID: 26489382
47. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. PMID: 26997499
48. membrane-anchored Mff differentially regulates various Drp1 isoforms. PMID: 26578513
49. These findings provide a mechanism wherein the multimeric states of both Mff and Drp1 regulate their collaborative interaction. PMID: 26578514
50. Results showed that DRP1 participated in pulmonary arterial angiogenesis through promoting the migration, stimulating the proliferation, and inhibiting the apoptosis of pulmonary artery endothelial cells via mitochondrial Ca2+. PMID: 25752284

Show More

Hide All

KEGG: mmu:74006

UniGene: Mm.218820