Recombinant Mouse E3 ubiquitin-protein ligase MGRN1 (Mgrn1)

1. Mgrn1 can negatively regulate signaling through the Hedgehog pathway by reducing cell-surface and ciliary levels of Smoothened, an oncoprotein that transmits the Hedgehog signal across the membrane. PMID: 29290584
2. With aging, the neuroprotective e3 ligase MGRN1 relocates from the cytosol to the nucleus of neurons, where it associates with chromatin and potentiates the cellular response to proteotoxic stress. This nuclear shift is due to a proteasome impairment dependent increase of a monoubiquitinated form of MGRN1. PMID: 28475871
3. Findings suggest that mahogunin ring finger-1 contributes to the clearance of toxic mutant copper-zinc superoxide dismutase inclusions likely through autophagic pathway. PMID: 26607786
4. Mahogunin-mediated alpha-tubulin ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation. PMID: 24556679
5. This study indicates the mahogunin deficiency results in the infertility of male mice, disruption of hormones secretion and impaired active progressive motility. PMID: 23210986
6. ATRN also has no effect on prion disease onset or progression and discuss possible mechanisms that could cause vacuolation of the central nervous system in Mgrn1 and Atrn null mutant mice PMID: 23787699
7. pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4. PMID: 23253940
8. Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PMID: 23383230
9. positional cloning of mahoganoid, encoding a novel 494-amino acid protein containing a C3HC4 RING (really interesting new gene) domain that may function as an E3 ubiquitin ligase PMID: 12438443
10. a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion diseases but without accumulation of protease-resistant prion protein PMID: 12560552
11. Mahoganoid mutation (Mgrn1md) on insulin sensitivity suggests that Mgrn1md may be increasing insulin sensitivity via the hypothalamic melanocortin-3 receptor pathway. PMID: 16638826
12. Mgrn1 mutant embryos show abnormal expression of asymmetrically expressed genes involved in LR patterning. PMID: 17075880
13. Our results indicate that reduced levels of MGRN1 cause the pigmentation phenotypes of Mgrn1 mutant mice and that there are no significant differences in the function of the four MGRN1 isoforms in pigment-type switching. PMID: 17083490
14. Loss of E3 ubiquitin ligase MGRN1 in mutant mice causes neurodegeneration via accumulation of its substrates. PMID: 17720281
15. data show that different Mgrn1 isoforms are not functionally equivalent in vivo and that the presence of only isoform I or III is sufficient for normal development, pigmentation, and neuronal integrity PMID: 19422019
16. study shows ASIP-MC1R signaling includes a cAMP-independent pathway through attractin and mahogunin, while the known cAMP-dependent component requires neither attractin nor mahogunin PMID: 19493315
17. Study shows that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration. PMID: 19524515

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KEGG: mmu:17237

STRING: 10090.ENSMUSP00000023159

UniGene: Mm.291326