Recombinant Mouse Endothelial PAS domain-containing protein 1 (Epas1), partial

1. Increased HIF-2alpha expression is associated with the development of severe pulmonary hypertension. PMID: 29074488
2. EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4thorn T cells. PMID: 28067314
3. Myeloid-specific deletion of Epas1 had no impact on the number of myeloid cells migrating into the eye. PMID: 28112274
4. Defect in nephron formation in PHD2/PHD3 double mutants required intact hypoxia-inducible factor-2 signaling and was dependent on the extent of stromal hypoxia-inducible factor activation. Thus, hypoxia-inducible factor prolyl-4-hydroxylation in renal interstitial cells is critical for normal nephron formation. PMID: 28847650
5. Absence of Hif2a in retinal neuroprogenitor cells causes a marked reduction of proliferating endothelial cells at the angiogenic front. This results in delayed retinal vascular development, fewer major retinal vessels and reduced density of the peripheral deep retinal vascular plexus. PMID: 29615467
6. HIF2alpha is linked to tumor suppression in neuroblastoma. PMID: 28696319
7. HIF-1alpha-dependent, HIF-2alpha-independent angiogenesis and constitutive diuresis is caused by Vhl deletion in renal epithelia PMID: 27528422
8. Data show that Tet1 modulates HIF-2alpha and HIF-1alpha through different mechanisms. PMID: 29036334
9. intestine HIF-2alpha regulates ceramide metabolism mainly from the salvage pathway, by positively regulating the expression of Neu3, the gene encoding neuraminidase 3. These results suggest that intestinal HIF-2alpha could be a viable target for hepatic steatosis therapy PMID: 29035368
10. endothelial EPAS1 has a global protective role during glomerular hypertensive injuries without influencing the hypertensive effect of angiotensin II PMID: 28928136
11. findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 activity PMID: 28848049
12. Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation. PMID: 28527294
13. this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection PMID: 27671111
14. in neurons HIF-1 and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke PMID: 26746864
15. HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors. PMID: 27956697
16. AQP1 deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha. PMID: 26649797
17. HIF1alpha and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments. PMID: 28232488
18. Data identify endothelial HIF-2 as a key transcription factor in the pathogenesis of pulmonary hypertension. PMID: 26976644
19. eIF3e is an angiogenesis suppressor. Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity. PMID: 25758454
20. The regulatory connection between HIF-2alpha and VEGFR-1, VEGFR-2 and MMP2. PMID: 27075652
21. HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon signaling. PMID: 26853750
22. demonstrate that HIF-2alpha is clearly implicated in the TSP1 pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction PMID: 26503986
23. Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction. PMID: 26241779
24. This review emphasizes that sympathetic nervous system homeostasis is dependent on a balance between HIF-2alpha and HIF-1alpha. PMID: 25953833
25. genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO production under conditions of epithelial HIF activation in the kidney. PMID: 26927670
26. Chondrocytes co-cultured with HIF-2alpha-overexpressing fibroblast-like synoviocytes exhibited upregulation of Mmp3 and Mmp13, which is similar to the effects induced by interleukin (IL)-6 treatment of chondrocytes. PMID: 26642431
27. HIF-2alpha inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma. PMID: 26837714
28. HIF-2alpha-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1) and a dysfunctional thermogenic response to cold exposure. PMID: 26572826
29. Activation of the HIF signaling pathway could be an important pathogenetic event in the development and progression of at least a subset of these tumors. PMID: 26348575
30. Loss of Hif-2alpha Rescues the Hif-1alpha Deletion Phenotype of Neonatal Respiratory Distress In Mice PMID: 26422241
31. although Hif-1alpha and Hif-2alpha synergize to suppress the development of acute myeloid leukemia, they are not required for leukemic stem cells maintenance. PMID: 26642852
32. Letter: HIF2alpha is expressed in a distinct spatial and temporal pattern throughout venous thrombus resolution. PMID: 25087887
33. Results show that HIF2-a is up regulated in an in vitro model of nicotine plus lipopolysccharide-stimulated periodontal ligament cell line and primary culture. Its inhibition exhibits anti-inflammatory activity. PMID: 25565665
34. High expression of HIF-2A is associated with leukemia and lymphoma. PMID: 25921247
35. HIF2alpha has a cardiomyogenesis-promoting effect in embryonic stem cells via enhancing the activation of the Wnt/beta-catenin signaling pathway. PMID: 25889500
36. data suggest that targeting intestinal HIF-2alpha has a significant therapeutic potential in SCD pathophysiology PMID: 26296885
37. these results suggest that PTEN is required for apoptosis-mediated cavitation during epithelial morphogenesis by regulating the expression of HIF-2alpha and Bnip3 PMID: 25394489
38. excess in pancreatic beta-cells does not play a significant role in beta-cell function and glucose homeostasis PMID: 25833250
39. details the importance of breast milk iron in neonatal development and uncovers an unexpected molecular mechanism for the regulation of nutritional status of breast milk through intestinal HIF-2alpha PMID: 26124130
40. Hif-2alpha activation augments peroxisome turnover by selective autophagy (pexophagy) and thereby changes lipid composition reminiscent of peroxisomal disorders. PMID: 25440060
41. pivotal role in the pathogenesis of rheumatoid arthritis by regulating fibroblast-like synoviocyte functions, independent of HIF-1alpha PMID: 24914685
42. The PTEN/PI3K/AKT signaling axis controls hypoxia-induced HIF1alpha (HIF1A) and HIF2alpha (EPAS1) stability in macrophages. PMID: 25103499
43. Hypoxia-mediated changes in cardiac mitochondrial function are a conserved target of both HIF-dependent and independent signaling pathways. PMID: 24607765
44. we showed that muscles did not require macrophagic hif1a or hif2a to regenerate. These results indicate that macrophagic HIFs do not play a crucial role during skeletal muscle regeneration induced by sterile tissue damage. PMID: 25750431
45. These results suggest that there is a compensatory pathway involving HIF-1alpha that regulates the expression of some HIF-2alpha target genes. PMID: 25557133
46. 713 HIF-1 and 795 HIF-2 binding sites were identified under hypoxia. Pretreatment with IL-10 altered the binding pattern, with 120 new HIF-1 and 188 new HIF-2 binding sites emerging PMID: 25450522
47. Chronic activation of HIF-2 in renal juxtaglomerular cells leads to a reprogramming of the cells into fibroblast-like cells resembling native erythropoietin-producing cells located in the tubulointerstitium. PMID: 25071089
48. activation of HIF2alpha/VE-PTP signaling via PHD2 inhibition has the potential to prevent the formation of leaky vessels and edema in inflammatory diseases such as ARDS PMID: 25574837
49. Hypoxic treatment of primary keratinocytes induced filaggrin (Flg) gene expression in a HIF1alpha- and HIF2alpha-dependent manner. PMID: 24999590
50. HIF-2alpha/IGF-1R signal loop supports the proliferation and Oct4 maintenance of mouse germline stem cells. PMID: 24598112

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KEGG: mmu:13819

STRING: 10090.ENSMUSP00000024954

UniGene: Mm.1415