Recombinant Mouse Eukaryotic translation initiation factor 2-alpha kinase 3 (Eif2ak3), partial

1. Leishmania infection results in phosphorylation and activation of host PERK enzyme and increased transcription of genes of inhibitor of apoptosis gene family (cIAP) mRNA. PMID: 30036391
2. These results suggest that the translational control mediated by PERK is a critical determinant of extracellular matrix secretion in chondrocytes. PMID: 29335505
3. PERK regulates oligodendrocyte survival during differentiation. PMID: 27416896
4. Data suggest the activation of PERK is part of a protective response to mutant rhodopsin that ultimately limits photoreceptor cell death. PMID: 29036441
5. heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 (GCN2) are sufficient for the integrated stress response; there are no additional eIF2alpha kinases in vertebrates PMID: 27633668
6. In response to endoplasmic reticulum stress, activation of PERK coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis. PMID: 27802424
7. These findings identify DLK as a central regulator of not only JNK but also PERK stress signaling in neurons, with both pathways contributing to neurodegeneration. PMID: 28440222
8. PERK has a role in mediating the internal ribosome entry site-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress PMID: 27141928
9. NDRG2 is a novel ERS-responsive protein and acts as PERK co-factor to facilitate PERK branch, thereby contributing to ERS-induced apoptosis. PMID: 28948615
10. the impaired working memory in forebrain-specific Perk knockout mice may stem from altered Gq protein-coupled intracellular Ca(2+) dynamics in cortical pyramidal neurons. PMID: 27716400
11. Overall, these data demonstrate that hypoxia can suppress adiponectin expression and activate the PERK and IRE1 signaling pathways in differentiated adipocytes, and this two pathways are involved in the suppression of adiponectin expression induced by hypoxia. PMID: 28888981
12. regulates both Ca2+ -dependent working memory and protein synthesis-dependent memory flexibility PMID: 27627766
13. In many endoplasmic reticulum (ER) stress-related disorders, activation of the unfolded protein sensor protein kinase RNA-like ER kinase (PERK) kinase is beneficial. Nonetheless, in Charcot-Marie-Tooth 1B neuropathy mice, we show that activation of PERK in Schwann cells, but not in neurons, is detrimental for myelination. PERK may interfere with myelination, independent of its role in ER stress. PMID: 27807175
14. ER-stressed astrocytes can drive an inflammatory M1-like phenotype in microglia, and this can be attenuated with inhibition of PERK. Importantly, targeting PERK neither disrupted normal cytokine signaling in astrocytes or microglia nor impaired macrophage phagocytosis or T cell polarization. PMID: 27226638
15. These results suggest that PERK signaling promotes medulloblastoma tumorigenesis by attenuating apoptosis of premalignant granule cell precursors during the course of malignant transformation. PMID: 27181404
16. These results suggest that the PERK arm of the unfolded protein response plays a pivotal role in the regulation of satellite cell homeostasis during regenerative myogenesis. PMID: 28332979
17. This study demonstrated that Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy. PMID: 27095827
18. Data show that EIF2AK3/PERK-mediated downregulation of miR-424(322)-503 cluster regulates optimal activation of IRE1 protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress. PMID: 26674075
19. Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases. PMID: 27103515
20. PlGF inhibition attenuates PERK activation, likely by tempering hypoxia in HCC via vessel normalisation. The UPR is able to regulate PlGF expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR PMID: 26753564
21. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses. PMID: 26434994
22. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK. PMID: 26446798
23. Results show that PERK-eIF2alpha-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau PMID: 26450683
24. whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 protein levels and signaling in pancreatic tissues. PMID: 26627716
25. PGRN is a key regulator of insulin resistance and PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2alpha dependent pathway PMID: 26039714
26. findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes PMID: 26449458
27. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation PMID: 25183803
28. interface mutations that disrupt tetramer formation in vitro reduce phosphorylation of PERK and its target eIF2alpha in cells. PMID: 25925385
29. Neoplastic de-differentiation confers multidrug resistance via non-canonical PERK-Nrf2 signaling. PMID: 25203443
30. It mediates eIF2alpha phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in Alzheimer's disease. PMID: 24889041
31. These results suggest that an optimal level of PERK expression is necessary to balance several parameters of beta-cell function and growth in order to achieve normoglycemia. PMID: 24915520
32. Suggest role for PERK in modulating fluoride induced bone formation and bone resorption. PMID: 25132241
33. This study demonistrated that the eIF2alpha kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression in mice. PMID: 24741110
34. PERK signaling provides protection to oligodendrocytes against inflammatory demyelination. PMID: 24481666
35. Findings suggest that protein kinase R-like endoplasmic reticulum kinase (PERK) is required to protect the heart from pressure overload-induced congestive heart failure. PMID: 24958502
36. Disruption of PERK abrogates endoplasmic reticulum stress-induced activation of STAT3 via JAK1. PMID: 25113558
37. PERK activation cell-autonomously enhances the survival and preserves function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases. PMID: 24269558
38. Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug. PMID: 23144714
39. GnRH exerts translational control to modulate physiologically relevant gene expression through EIF2AK3 and MAPK signaling. PMID: 24161835
40. interplay between calcineurin and PERK regulates beta-cell Ca(2+) signaling and insulin secretion, and that loss of this interaction may have profound implications in insulin secretion defects associated with diabetes. PMID: 24114838
41. increased autophagy, secondary to persistent PERK and LKB1-AMPK signaling, can robustly protect cells from anoikis and promote luminal filling during early carcinoma progression PMID: 23160380
42. PERK is a key regulator of mitochondrial morphology and function.Mfn2 is an upstream modulator of PERK PMID: 23921556
43. Perk-dependent cell death and led to a significant decrease in the levels of miRNAs belonging to miR-106b-25 cluster in wild-type (WT) but not in Perk/ MEFs PMID: 22739985
44. The results of this study provided direct evidence that activation of PERK signaling in oligodendrocytes is cytoprotective, protecting mice against EAE. PMID: 23554479
45. An unprecedented role of PERK as a MAMs component required to maintain the ER-mitochondria juxtapositions and propel ROS-mediated mitochondrial apoptosis. PMID: 22705852
46. Deletion of PERK in either young adult or mature adult mice resulted in hyperglycemia associated with loss of islet and beta cell architecture PMID: 23071091
47. Results suggest that compromised induction of Unfolded Protein Response (UPR) and increased NOXA expression contributes to hypersensitivity of PERK(-/-) MEFs to ER stress-induced apoptosis. PMID: 23068609
48. the PERK/eIF2-alpha-P/ATF4 pathway is required not only for translational control, but also for activation of ATF6 and its target genes; findings show that the regulatory networks of the unfolded protein response are fully integrated and help explain biological defects associated with loss of PERK PMID: 21917591
49. PERK is activated in cerebellar dysplasia and medulloblastoma of interferon (IFN)gamma-expressing mice. PMID: 21688289
50. Transcriptional profiling by cDNA microarray combined with reverse genetics revealed phosphorylation of the eukaryotic initiation factor 2-alpha (EIF2A) through the eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3/PERK). PMID: 22253692

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KEGG: mmu:13666

STRING: 10090.ENSMUSP00000034093

UniGene: Mm.247167