EIF2AK3

Eukaryotic translation initiation factor 2-alpha kinase 3 is a protein in humans that is encoded by EIF2AK3 gene. Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

EIF2AK3 Antibodies

EIF2AK3 Antibodies for Homo sapiens (Human)

EIF2AK3 Proteins

EIF2AK3 Proteins for Homo sapiens (Human)

EIF2AK3 Proteins for Mus musculus (Mouse)

EIF2AK3 Proteins for Rattus norvegicus (Rat)

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