Recombinant Mouse Forkhead box protein Q1 (Foxq1)

Code CSB-YP008845MO
MSDS
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Source Yeast
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Code CSB-EP008845MO
MSDS
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Source E.coli
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Code CSB-EP008845MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP008845MO
MSDS
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Source Baculovirus
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Code CSB-MP008845MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Foxq1
Uniprot No.
Alternative Names
Foxq1; Hfh1; Hfh1lForkhead box protein Q1; HFH-1l; HNF-3/forkhead-like protein 1; HFH-1; Hepatocyte nuclear factor 3 forkhead homolog 1
Species
Mus musculus (Mouse)
Expression Region
1-400
Target Protein Sequence
MKLEVFVPRA AHGDKMGSDL EGAGSSDVPS PLSAAGDDSL GSDGDCAANS PAAGSGAGDL EGGGGERNSS GGPSAQDGPE ATDDSRTQAS AAGPCAGGVG GGEGARSKPY TRRPKPPYSY IALIAMAIRD SAGGRLTLAE INEYLMGKFP FFRGSYTGWR NSVRHNLSLN DCFVKVLRDP SRPWGKDNYW MLNPNSEYTF ADGVFRRRRK RLSHRTTVSA SGLRPEEAPP GPAGTPQPAP AARSSPIARS PARQEERSSP ASKFSSSFAI DSILSKPFRS RRDGDSALGV QLPWGAAPCP PLRAYPALLP AAPGGALLPL CAYGASEPTL LASRGTEVQP AAPLLLAPLS TAAPAKPFRG PETAGAAHLY CPLRLPTALQ AAAACGPGPH LSYPVETLLA
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Plays a role in hair follicle differentiation.
Gene References into Functions
  1. FOXQ1 is a novel factor involved in regulating hepatic gluconeogenesis, and the decreased FOXQ1 expression in liver may contribute to the development of type 2 diabetes. PMID: 27421728
  2. R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla in mice. PMID: 23489430
  3. This study has elucidated the functional impact of FoxQ1 on epithelial differentiation. PMID: 20717954
  4. satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation PMID: 16835220
  5. Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi. PMID: 18544931
  6. Transcription factor foxq1 controls MUC5AC gene expression and granule content in mouse stomach surface mucous cells. PMID: 18558092

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Involvement in disease
Defects in Foxq1 are the cause of the satin (sa) phenotype and results in a silky coat with high sheen arising from structurally abnormal medulla cells and defects in differentiation of the hair shaft.
Subcellular Location
Nucleus.
Tissue Specificity
Expressed in kidney and stomach. Expression in the outer medulla of the kidney and the transitional epithelium. Expressed in the hair follicle medulla.
Database Links
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