Recombinant Mouse Four and a half LIM domains protein 2 (Fhl2)

1. Fhl2 anticipates the emerging inflammation and specifically the development of psoriatic arthritis by impeding the Adam17-mediated release of TNF PMID: 28823868
2. FHL2 facilitates ovarian granulosa cell tumor progression via controlling AKT1 transcription. PMID: 27415427
3. Loss of FHL2 is associated with liver fibrosis. PMID: 28223370
4. loss of Fhl2 leads to an altered immune response to myocardial ischemia, which results in smaller infarcts and better hemodynamic performance up to 21 days after myocardial ischemia reperfusion. PMID: 26921632
5. also found that phosphorylation of ERK1/2 is markedly attenuated in FHL2-KO lung PMID: 26222912
6. Overexpression of FHL2 alone had no effect on Erbin expression, but in the presence of MITF, Erbin expression was decreased. PMID: 26025865
7. these data identify a previously unrecognized role for FHL2 in the pathogenesis of pulmonary granulomatous inflammation PMID: 26300344
8. we conclude that FHL2 has both structural and functional protein-protein interactions with b-catenin in the podocyte nucleus and that FHL2 protein inhibition can mitigate Wnt/b-catenin-induced podocytopathy. PMID: 25855776
9. FHL2 serves as a protective factor and that, rather than promoting the pathology, the upregulation of FHL2 in RA occurs in frame of a regenerative attempt. PMID: 25125695
10. FHL2 regulates hematopoietic stem cell functions under transplantation-induced stress conditions. PMID: 25179730
11. The LIM-only protein FHL2 reduces vascular lesion formation involving inhibition of proliferation and migration of smooth muscle cells. PMID: 24736599
12. a database of genes that are regulated by FHL2 in liver PMID: 24453047
13. FHL2-deficient mice developed a severe and long-lasting lung pathology due to enhanced expression of tenascin C and impaired activation of inflammation-resolving macrophages. PMID: 24260575
14. Early Wnt/beta-catenin-dependent transcriptional activation mediated by FHL2 is important for the transition to and expansion of early cardiogenic mesodermal cells. PMID: 23341242
15. Deficiency of FHL2 reduced susceptibility to diethylnitrosamine-induced hepatocarcinogenesis, correlating with the activator function of FHL2 in NF-kappaB signaling. PMID: 23775124
16. Deficiency of FHL2 results in aggravation of murine liver fibrosis. PMID: 23311569
17. Ex vivo analysis showed decreased basal and Wnt3a-induced Wnt5a and Wnt10b mRNA expression in FHL2-deficient bone marrow cells, further indicating that this defect may contribute to the reduced osteoblast function in FHL2 deficient mice PMID: 23201222
18. The four and a half LIM-only protein 2 regulates liver homeostasis and contributes to carcinogenesis. PMID: 22796152
19. ROCK2 is essential for the development of cardiac hypertrophy and that up-regulation of FHL2 may contribute to the antihypertrophic phenotype that is observed in cardiac-specific ROCK2-deficient mice. PMID: 23271052
20. Deficiency of FHL2 impairs ischemia-induced neovascularization, and these suppressive effects may occur through a reduction in proangiogenic cell mobilization, migration, and vasculogenesis functions. PMID: 23413425
21. FHL2 might play an important role in ameloblast and odontoblast differentiation, secretion of enamel and dentin matrix, mineralization of enamel, molar crown morphogenesis, as well as root formation. PMID: 22461197
22. Observed is increased expression of isoproterenol-activated NFAT target genes in Fhl2-/- mice. PMID: 22851699
23. FHL2-mediated induction of IL-6 was regulated by the activation of IL-6 promoter through stimulating NF-kappaB and p38 MAPK signaling pathway. PMID: 22633286
24. role of FHL2 in intestinal tumorigenesis in which activation of the Wnt pathway by mutations in the adenomatous polyposis coli gene (Apc) or in beta-catenin constitutes the primary transforming event PMID: 20442768
25. Collectively, these studies define a Fhl2-Foxk1 cascade that regulates the myogenic progenitor cell activity in adult skeletal muscle and enhances our understanding of muscle regeneration. PMID: 20013826
26. A role for FHL2 is demonstrated in atherogenesis, the regulation of circular nitric oxide release, and expression of gap junctions within aortic endothelium. PMID: 20096293
27. FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells PMID: 15117962
28. data describe a novel differential regulation of Hand1 heterodimers versus homodimers by association of the cofactor FHL2 and provide insight into the potential for a tertiary level of control of Hand1 activity in the developing heart PMID: 15509787
29. antagonizes induction of smooth muscle genes by competing with the coactivator MAL/MRTF-A for SRF binding PMID: 15610731
30. Fhl2 increases the transcriptional activity of runt-related transcription factor 2 (Runx2) PMID: 16079911
31. FHL2 plays an important role in osteoblast differentiation and bone formation. PMID: 16355270
32. four-and-a-half LIM 2 has a role in bone mineral content and bone mineral density in femur and tibia bones PMID: 16927043
33. MuRF3 has an essential role in maintaining cardiac integrity and function after acute myocardial infarction and turnover of FHL2 and gamma-filamin contributes to this cardioprotective function of MuRF3 PMID: 17360532
34. Fhl2 is a lipid-triggered signaling molecule in mesenchymal cells regulating migration and contraction during cutaneous wound healing. PMID: 17420295
35. Role of FHL2 in bundling of focal adhesion structures, in integrin-mediated ERK activation, and subsequently in proper allocation of matrix proteins on the cell surface. PMID: 18356303
36. The decreased chemical-induced corneal angiogenesis found in the FHL2-null mice in this study indicated that FHL2 protein plays a role in inhibiting inflammatory angiogenesis. PMID: 18708619
37. FHL2 is an important factor regulating collagen expression in the early phase of wound healing. PMID: 18950620
38. deregulation of FHL2 contributes to the development of human myeloid disorders. PMID: 19369964

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KEGG: mmu:14200

STRING: 10090.ENSMUSP00000008280

UniGene: Mm.6799