Recombinant Mouse G protein-coupled receptor kinase 6 (Grk6)

1. Conditions for optimal dendritic cells guidance are perfectly provided by the CCL21 gradients measured in vivo. Furthermore, CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo. PMID: 28457871
2. These studies suggest a previously unrecognized and novel role for GRK6 in neutrophil migration specific to pulmonary tissue during bacterial infection. PMID: 28939643
3. Silencing of GRK6 expression by siRNA impairs CXCR4-serine 339 phosphorylation and migration of cardiac stem cellss caused by SCF. In vivo, knockdown of GRK6 impairs the ability of CSCs to migrate into peri-infarcted areas. PMID: 27245949
4. This work demonstrates the importance of GRK6 in regulation of hematopoietic stem cell self-renewal and reveals its potential role in participation of stress response. PMID: 27882944
5. GRK6-mediated OXTR desensitization in labor is necessary for normal uterine contractile patterns and optimal fetal outcome. PMID: 26886170
6. It regulates apoptotic engulfment in phagocytes. (review) PMID: 26234352
7. these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. PMID: 24510965
8. data demonstrate that GRK6 plays a feedback regulatory role in CXCR2-mediated tumor development, invasion and metastasis PMID: 23589623
9. G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance. PMID: 23443560
10. Chemokine receptor CXCR2 interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis. PMID: 22869904
11. Results identify GRK5/6 as novel kinases for the single transmembrane receptor LRP6 during Wnt signaling. PMID: 19801552
12. deficiency causes defective lymphocyte chemotaxis PMID: 12032308
13. Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity. PMID: 12718862
14. In the absence of GRK6, the G-CSF-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF, significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice. PMID: 14704365
15. The results suggest that mouse G-protein-coupled receptor kinase isoform 6-C may be considered a basic, prototypic representative of the GRK4-like kinases. PMID: 16302968
16. GRK6 and -2, but not GRK5, are involved in the pathogenesis of acute arthritis in the K/BxN model. In particular, GRK6 may dampen inflammatory responses by regulating granulocyte trafficking toward chemoattractants. PMID: 18662895
17. Data show an important protective role for GRK6 against post-inflammatory visceral hyperalgesia. PMID: 18977289
18. these results suggest that GRK6 may play a role in regulating some, but not all morphine-mediated responses. PMID: 19497686

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KEGG: mmu:26385

STRING: 10090.ENSMUSP00000001115

UniGene: Mm.10193