Recombinant Mouse Glycoprotein hormones alpha chain (Cga)

Code CSB-YP005293MO
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Source Yeast
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Code CSB-EP005293MO
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Source E.coli
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Code CSB-EP005293MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005293MO
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Source Baculovirus
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Code CSB-MP005293MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Cga
Uniprot No.
Alternative Names
CgaGlycoprotein hormones alpha chain; Anterior pituitary glycoprotein hormones common subunit alpha; Follicle-stimulating hormone alpha chain; FSH-alpha; Follitropin alpha chain; Luteinizing hormone alpha chain; LSH-alpha; Lutropin alpha chain; Thyroid-stimulating hormone alpha chain; TSH-alpha; Thyrotropin alpha chain
Species
Mus musculus (Mouse)
Expression Region
25-120
Target Protein Sequence
LPDGDF IIQGCPECKL KENKYFSKLG APIYQCMGCC FSRAYPTPAR SKKTMLVPKN ITSEATCCVA KAFTKATVMG NARVENHTEC HCSTCYYHKS
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Gene References into Functions
  1. Data suggest that expression of Rps6ka5 in gonadotroph cell line is up-regulated by GnRH signaling and is required for Cga expression; GnRH-activates Rps6ka5 targets at the first nucleosome just downstream from the transcriptional start site. (Rps6ka5= mitogen and stress-activated protein kinase 1; GnRH = gonadotropin-releasing hormone; Cga = gonadotropin alpha subunit) PMID: 29054929
  2. TSH improves insulin sensitivity in skeletal muscle by increasing Irs1 gene expression. PMID: 27452800
  3. Oncogene-induced senescence is initiated in Braf(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 expression by upregulating the PI3K/AKT pathway and inhibiting OIS, resulting in tumor progression. PMID: 26477313
  4. the Cga eRNA mediates the physical interaction between genomic regions and determines the chromatin structure of the proximal promoter to allow gene expression PMID: 25810254
  5. Data suggest that highly bioactive luteinizing hormone (LH; both alpha [Cga] and beta [Lhb] subunits) is produced by embryo/blastocyst at time of implantation; LH bioactivity remains constant in blastocyst on days 5-10 after fertilization. PMID: 23464498
  6. Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH. PMID: 23524969
  7. We have identified a post-transcriptional regulatory network active during mouse pituitary development in which the expression of the hormone alphaGSU is increased by let7b/c through downregulation of KSRP PMID: 22844247
  8. results suggest that in alphaT3-1 cells, dopamine D(2) receptors negatively regulate pituitary gonadotropin alpha subunit gene expression in association with the cAMP-dependent pathway PMID: 12297539
  9. These results suggest that ADCYAP1 mainly increases Cga through activation of PKA and MAPK3/1, as well as through an additional unknown pathway. PMID: 17596563

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Subcellular Location
Secreted.
Protein Families
Glycoprotein hormones subunit alpha family
Database Links
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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