Recombinant Mouse Hepatocyte nuclear factor 1-alpha (Hnf1a)

1. TCF-1 controls T cell fate is through its widespread ability to target silent chromatin and establish the epigenetic identity of T cells. PMID: 29466756
2. Tcf1 binding reduced the activity of a Gzmb-associated regulatory element, and this accounted for the reduced Gzmb expression in Tcf1-expressing NK cells. PMID: 28723565
3. Transcriptional analysis revealed 4 important genes involved in sphingolipid metabolism to be deregulated in HNF1A deficiency: Ormdl1, sphingosine kinase-2, neutral ceramidase, and ceramide synthase-5. PMID: 29109103
4. This is attributed in part to ineffective repression of Tcf1 expression in knockout T cells, as DNMT3a localizes to the Tcf7 promoter and catalyzes its de novo methylation in early effector WT CD8(+) T cells. These data identify DNMT3a as a crucial regulator of CD8(+) early effector cell differentiation and effector versus memory fate decisions. PMID: 27582468
5. We identified PD-1 to be specifically expressed in PLZF(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3, ID2, and TCF-1 was critical. Importantly, induction of ILC lineage commitment required only transient expression of NFIL3 prior to ID2 and TCF-1 expression. PMID: 27705792
6. Knockdown of MACF1 in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin/TCF1-Runx2 axis. PMID: 28621459
7. Lef1 and Tcf1 showed oncogenic effect in colonic carcinogenesis. Cellular context of miRNAs might play important roles in carcinogenesis by altering the expression pattern of Lef/Tcfs members. PMID: 27433921
8. this study found that virus-specific CD8(+) T cells that sustained the T cell response during chronic viral infection are defined by, and depended on, the expression of Tcf1 PMID: 27533016
9. data demonstrate a novel miR-24-TCF1 pathway in controlling effector cytokine production by T cells and further suggest miR-24 could function as a key upstream molecule regulating TCF1-mediated immune responses. PMID: 28404635
10. HNF1alpha plays a crucial role in hepatocyte lipid metabolism and hepatocarcinogenesis PMID: 28547778
11. Data show that TCF1 proteindeficiency relieved most manifestations of autoimmune lymphoproliferative syndrome (ALPS)-like phenotype, which were caused by Fas protein mutation in TCF1(-/-) lpr/lpr mice. PMID: 28349581
12. Data show that the Wnt-effector hepatocyte nuclear factor 1-alpha (Tcf1) is recruited to and triggers transcription of the Ink4/Arf tumor suppressor locus, such as as p15Ink4b, p16Ink4a and p19Arf. PMID: 28346462
13. this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1, GATA-3 and Runx1) activate Bcl11b for T cell commitment PMID: 27376470
14. this study shows that the transcription factors Tcf1 and Lef1 suppress CD4+ T lineage genes in CD8+ T cells through intrinsic histone deacetylase activity PMID: 27111144
15. Results show that Tcf1 binding to Zfp703 inhibits beta-catenin/Tcf1 complex formation. PMID: 27090637
16. this study shows that Tcf1 short isoforms are adequate in supporting developing thymocytes to traverse through maturation steps and in regulating the expression of most Tcf1 target genes PMID: 28348272
17. HNF1alpha plays a key role in the constitutive expression of megalin and cubilin, hence regulating endocytosis in the proximal tubule of the kidney. PMID: 27083284
18. leukemic stem cells are therefore more sensitive to loss of Tcf1 and Lef1 than Hematopoietic Stem Cells in their self-renewal capacity. PMID: 27044748
19. Sp5/8 bind directly to GC boxes in Wnt target gene enhancers and to adjacent, or distally positioned, chromatin-bound T-cell factor (Tcf) 1/lymphoid enhancer factor (Lef) 1 to facilitate recruitment of beta-catenin to target gene enhancers. PMID: 26969725
20. TCF1 is required for the T follicular helper cell response to viral infection functioning through negative feedback loops with IL-2 and Blimp1. PMID: 26365183
21. Our data demonstrate that HNF1A is an important cell-intrinsic transcription factor in adult B lymphopoiesis PMID: 26800876
22. This paper demonstrates a cell-intrinsic requirement for transcription factors TCF1 and LEF1 for the development of all subsets of Natural Killer T cells. PMID: 26490636
23. Beta-catenin's function in regulating mouse embryonic stem cells is highly context specific and its interaction with TCF1 promotes differentiation. PMID: 26459597
24. HNF1alpha, but not HNF1beta, is the primary positive regulator of PCSK9 transcription in mouse liver PMID: 25652089
25. IP3R-mediated Ca2+ signaling reinforces Tcf-1 activity to both ensure normal development and to prevent thymocyte neoplasia. PMID: 25215520
26. critical for suppression of CD8-positive T-cell function PMID: 25355919
27. TCF-1 physically interacted with Runx3 to cooperatively silence Cd4. PMID: 24836425
28. Deletion of intestinal SIRT1 impairs DCoH2-HNF-1alpha-FXR signaling and alters systemic bile acid homeostasis. PMID: 24389307
29. the data strongly supports a critical role for HNF4a and Hnf1a in the tissue-specific regulation of drug handling and differentiation toward a PT-like cellular identity. PMID: 24038112
30. Loss of TCF-1 expression impaired the capacity of these innate lymphoid cell subsets to produce IL-5, IL-13, and IL-22 and resulted in crippled responses to intestinal infection with Citrobacter rodentium. PMID: 24038093
31. Lack of Tcf1 induces thymic lymphomas with high frequency. PMID: 23185135
32. Among all Muc5ac regulators, only GATA-6 and HNF-4a expression was concomitant to that of Muc5ac in the developing stomach. PMID: 22554936
33. HNF1alpha might regulate beta-cell mass or function at least partly by modulating Hgfac expression. PMID: 22877752
34. Dynamic changes in gene expression occur on pancreatitis induction, determining altered exocrine and endocrine function. This analysis uncovers roles for Hnf1alpha in the regulation of acinar cell determination and function. PMID: 21948943
35. The miR-192/-194 cluster was markedly down-regulated in liver of Tcf1(-/-) mice. PMID: 21887698
36. Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress. PMID: 21784843
37. Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis PMID: 21747169
38. a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels PMID: 21628466
39. Report the opposing effects of Tcf3 and Tcf1 control Wnt3a stimulation of embryonic stem cell self-renewal. PMID: 21685894
40. data suggest a model where Notch signals induce TCF-1, and TCF-1 in turn imprints the T-cell fate by upregulating expression of T-cell essential genes PMID: 21814277
41. Hnf1-alpha regulates MafA in beta-cells and compromised MafA expression contributes to beta-cell dysfunction in maturity onset diabetes of young mice. PMID: 21193557
42. These findings reveal a novel nutrient-dependent interaction between Sirt1 and HNF-1alpha which results in regulation of Crp expression. PMID: 21176092
43. Data indicate that HNF1alpha is a more potent activator of AFM promoter than is HNF1beta. PMID: 20979532
44. Although the phenotype of the Hnf1a-null mouse is complex, metabolomics has opened the door to investigation of several physiological systems in which Hnf1alpha may be a critical regulatory component. PMID: 20943816
45. HNF1alpha directly regulates the expression of ClC-5 in the renal proximal tubule PMID: 20810608
46. beta-catenin, Lef1 & Tcf1 are needed for Bmp4 expression maintaining Shh expression in the dental ectoderm. The number of incisors from one placode can be varied through local changes of a mesenchymal signaling circuit involving these proteins. PMID: 20883686
47. central role of DNA methylation in the kidney-specific expression of amino acid transporters thus determining both the tissue distribution of their master regulator, Hnf1alpha, and its interaction with downstream PMID: 20555317
48. a functional role for Hnf1alpha in regulating adult intestinal growth and sustaining the functions of intestinal epithelial cell lineages PMID: 20808783
49. findings provide an in vivo strategy to study combinatorial gene regulation and reveal how Hnf1alpha and Hnf4alpha control a common islet-cell regulatory program that is defective in human monogenic diabetes PMID: 20523905
50. Study identifies new direct target genes of the Hnf1a transcription factors and shows that they play crucial roles in both defining cell fate and controlling terminal functions in the gut epithelium. PMID: 20388655

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KEGG: mmu:21405

STRING: 10090.ENSMUSP00000031535

UniGene: Mm.332607