Recombinant Mouse Hepatoma-derived growth factor(Hdgf)

Code CSB-YP010249MO
Size US$2474
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP010249MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Hdgf.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP010249MO could indicate that this peptide derived from Yeast-expressed Mus musculus (Mouse) Hdgf.
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names Hdgf
Uniprot No. P51859
Research Area Cancer
Alternative Names Hdgf; Tdrm1; Hepatoma-derived growth factor; HDGF
Species Mus musculus (Mouse)
Source Yeast
Expression Region 1-237aa
Target Protein Sequence MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKKSCAAEPEVEPEAHEGDGDKKGSAEGSSDEEGKLVIDEPAKEKNEKGTLKRRAGDVLEDSPKRPKESGDHEEEDKEIAALEGERPLPVEVEKNSTPSEPDSGQGPPAEEEEGEEEAAKEEAEAQGVRDHESL
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 30.3kDa
Protein Length Full Length
Tag Info N-terminal 10xHis-tagged and C-terminal Myc-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).
Gene References into Functions
  1. liver cancer cell-derived HDGF can induce Foxp3(+) T cells; the latter has immune suppressor functions on CD8(+) T cell activities PMID: 25569374
  2. Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma. PMID: 23536873
  3. HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue. PMID: 22014102
  4. HDGF exploits the innate properties of both cell surface heparan sulfates and membrane receptor via the HATH domain to affect related cell signalling processes PMID: 20964630
  5. HDGF plays a pro-fibrogenic role during liver fibrosis in mice through activation of TGF-beta pathway. PMID: 19913322
  6. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus PMID: 11751870
  7. Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development. PMID: 12447878
  8. Increased HDGF expression is correlated with disease progression of hepatocellular carcinoma and represent a specific prognostic factor in patient with liver cancer. PMID: 14508832
  9. we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action. PMID: 14662017
  10. HDGF is a novel type of neurotrophic factor harbored in the nucleus and it functions in an autocrine manner. PMID: 15140875
  11. hepatoma-derived growth factor has roles in development and intestinal neoplasms PMID: 15604097
  12. HDGF is a novel trophic factor for motor neurons and it might play a protective role against motor neuron degeneration. PMID: 16987236
  13. The lack of obvious biochemical and morphological phenotypes in HDGF-deficient mice demonstrates that in vivo HDGF is dispensable for normal development in mice. PMID: 18570251

Show More

Hide All

Subcellular Location Cytoplasm, Nucleus
Protein Families HDGF family
Tissue Specificity Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen.
Database Links

KEGG: mmu:15191

STRING: 10090.ENSMUSP00000005017

UniGene: Mm.292208

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved. 鄂ICP备15011166号-1