Recombinant Mouse Hepatoma-derived growth factor(Hdgf)

Code CSB-EP010249MO
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Source E.coli
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Code CSB-EP010249MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP010249MO
Size Pls inquire other sizes
Source Baculovirus
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Code CSB-MP010249MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Hdgf
Uniprot No. P51859
Alternative Names Hdgf; Tdrm1; Hepatoma-derived growth factor; HDGF
Species Mus musculus (Mouse)
Expression Region 1-237
Target Protein Sequence MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCAA EPEVEPEAHE GDGDKKGSAE GSSDEEGKLV IDEPAKEKNE KGTLKRRAGD VLEDSPKRPK ESGDHEEEDK EIAALEGERP LPVEVEKNST PSEPDSGQGP PAEEEEGEEE AAKEEAEAQG VRDHESL
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).
Gene References into Functions
  1. liver cancer cell-derived HDGF can induce Foxp3(+) T cells; the latter has immune suppressor functions on CD8(+) T cell activities PMID: 25569374
  2. Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma. PMID: 23536873
  3. HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue. PMID: 22014102
  4. HDGF exploits the innate properties of both cell surface heparan sulfates and membrane receptor via the HATH domain to affect related cell signalling processes PMID: 20964630
  5. HDGF plays a pro-fibrogenic role during liver fibrosis in mice through activation of TGF-beta pathway. PMID: 19913322
  6. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus PMID: 11751870
  7. Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development. PMID: 12447878
  8. Increased HDGF expression is correlated with disease progression of hepatocellular carcinoma and represent a specific prognostic factor in patient with liver cancer. PMID: 14508832
  9. we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action. PMID: 14662017
  10. HDGF is a novel type of neurotrophic factor harbored in the nucleus and it functions in an autocrine manner. PMID: 15140875
  11. hepatoma-derived growth factor has roles in development and intestinal neoplasms PMID: 15604097
  12. HDGF is a novel trophic factor for motor neurons and it might play a protective role against motor neuron degeneration. PMID: 16987236
  13. The lack of obvious biochemical and morphological phenotypes in HDGF-deficient mice demonstrates that in vivo HDGF is dispensable for normal development in mice. PMID: 18570251

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Subcellular Location Cytoplasm, Nucleus
Protein Families HDGF family
Tissue Specificity Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen.
Database Links

KEGG: mmu:15191

STRING: 10090.ENSMUSP00000005017

UniGene: Mm.292208

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