Recombinant Mouse Homeobox protein Nkx-2.2 (Nkx2-2)

1. The transient hypoxia at P7 altered the expression of Nkx2.2, resulting in delayed myelination in the external capsule. PMID: 28546087
2. This suggests that Nkx2.2 is not only required in the early pancreatic progenitors, but has additional essential activities within the endocrine progenitor population. PMID: 28071588
3. Lmx1a is expressed in enterochromaffin cells and functions downstream of Nkx2.2. PMID: 27287799
4. nuclear import of Nkx2-2 is mediated not only by the classical import pathway but also directly by imp beta1 or imp 13 PMID: 27956177
5. Demonstrate that a rare mature enteroendocrine cell subpopulation that is demarcated by Nkx2.2 expression display stem cell properties during normal intestinal epithelial homeostasis, but is not easily activated upon injury. PMID: 26492922
6. that Nkx2.2 and Nkx2.9 proteins play no role in the development of branchiovisceral motor neurons in hindbrain rostral to rhombomere 4. PMID: 25919494
7. These data identify Nkx2.2 as key regulator to determine neuronal subtypes in the p3 domain of the central nervous system. PMID: 25840610
8. The study demonstrates a previously unrecognized mechanism that controls insulin expression through c-Abl-regulated NKx2.2 and GLUT2. PMID: 24835010
9. Our studies reveal that a subset of mouse perineurial cells are CNS-derived, express Nkx2.2, and are essential for motor nerve development. PMID: 24979729
10. NKX2-2 and MNX1 are etiological genes for neonatal diabetes. PMID: 24411943
11. Nato3 induces ectopic Foxa2-positive cells and indirectly downregulates Nkx2.2 expression. PMID: 24401371
12. Nkx2.2 functions as a major 'switch' to turn off Pdgfra signaling in oligodendrocyte precursor cells and initiate the intrinsic program for oligodendrocyte differentiation. PMID: 24449836
13. Sirt2 enhances CG4 oligodendroglial differentiation and report a novel mechanism through which Nkx2.2 represses CG4 oligodendroglial differentiation via Sirt2. PMID: 21669943
14. The NKX2-2 can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
15. Nkx2.2 acts by reinforcing the transcriptional networks initiated by Pax4 and Arx in early committed beta- and alpha-cell, respectively. PMID: 21880149
16. Mutation of the endogenous Nkx2.2 tinman (TN) domain in mice abolishes the interaction between Nkx2.2 and Grg3 and disrupts beta-cell specification PMID: 22056672
17. these experiments identify novel genetic interactions between Nkx2.2 and Arx within the endocrine progenitor cells that ensure the correct specification and regulation of endocrine hormone-producing cells PMID: 21856296
18. sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 are differently regulated in medulloblastoma and astrocytoma PMID: 21059263
19. Data argue that the Nkx2.2 and Nkx2.9 transcription factors contribute crucially to the formation of neuronal networks that function as central pattern generators for locomotor activity in the spinal cord. PMID: 21068056
20. Nkx2.2 can bind to ghrelin promoter;results suggest upregulation of ghrelin in Nkx2.2 null mice is not due to loss of repression of ghrelin promoter in nonghrelin islet cells; Nkx2.2 may contribute to activation of ghrelin in mature islet epsilon-cells PMID: 19965928
21. co-expression of Nkx2.2 and Nkx6.2 transcription factors in myelinating oligodendrocytes suggests their functional interactions in the regulation of myelin sheath formation and/or maintenance PMID: 19780200
22. Expression profiling of Nkx2.2-/- mice during embryogenesis has allowed identification of known and novel pancreatic genes that function downstream of Nkx2.2 to regulate pancreas development. PMID: 20003319
23. regulates expression of genes selectively expressed in islet beta cells PMID: 12426319
24. role of Pax4 appears to be accomplished via its genetic interaction with another homeobox gene, Nkx2.2 PMID: 14729487
25. Nkx2.2 and Pax4 are required to specify or maintain differentiation of the beta cell fate. PMID: 14970313
26. Data show that FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. PMID: 16847327
27. The control of oligodendrocyte differentiation by Olig2, Sox10 and Nkx2.2 is a dosage-dependent developmental process and can be affected by both haploinsufficiency and over-dosage. PMID: 17098222
28. Nkx2.2 functions predominantly as a transcriptional repressor during specification of endocrine cell types in the pancreas. PMID: 17202186
29. indicate a previously undiscovered role for Nkx2.2 in the maintenance of mature beta-cell function and the formation of normal islet structure PMID: 17456846
30. These studies identify a novel role for Nkx2.2 in intestinal endocrine cell development and reveal the regulatory similarities between cell type specification in the pancreatic islet and in the enteroendocrine population of the intestine. PMID: 18022152
31. During development, Phox2b and Nkx2.2 form a non-cell-autonomous feedback loop that links the neural crest with the pancreatic epithelium, and regulates the size of the beta-cell population. PMID: 18506029
32. These results together imply that Nkx2.2 antisense RNA has a certain biological function which is likely to be not only based on the affect on transcription level of Nkx2.2 coding gene in cis, but also on the other mechanisms. PMID: 18538132
33. NKX2.2 functions in immature endocrine cells to control neuroendocrine differentiation in normal intestine and is expressed in most neuroendocrine tumors of the gut PMID: 18987169
34. These data provide important insights into specific functions of PAX6 and NKX2.2 during glial cell specification that have so far remained largely unexplored. PMID: 19258013

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KEGG: mmu:18088

STRING: 10090.ENSMUSP00000069666

UniGene: Mm.330639