Recombinant Mouse Homer protein homolog 3 (Homer3)

Code CSB-YP860797MO
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP860797MO
MSDS
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Source E.coli
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Code CSB-EP860797MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP860797MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP860797MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Homer3; Homer protein homolog 3; Homer-3
Species
Mus musculus (Mouse)
Expression Region
1-356
Target Protein Sequence
MSTAREQPIF STRAHVFQID PTTKRNWIPA GKHALTVSYF YDATRNVYRI ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQQLT QFAEKFQEVK EAARLAREKS QDGGEFTSTG LALASHQVPP SPLVSTNGPG EEKLFRSQSA DTPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNQRLA GALREANAAA TQWRQQLEVQ RAEAELLRQR VAELEAQVAV EPVRAGEKEA TSQSVEQLEA RVQTKDQTLK NQSTGTREAP DTAEREETQQ QVQDLETRNA ELEQQLRSME CNLEEARAER ERARAEVGRA AQLLDVRLFE LSELREGLAR LAEAAP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
Gene References into Functions
  1. impaired mTORC1-Homer-3 activity underlies PC susceptibility in Spinocerebellar ataxia type 1 and presents a promising therapeutic target PMID: 26748090
  2. Expression of Homer 3a/b is restricted to the developing cerebellum, hippocampus, and neonatal olfactory bulb, and is concentrated in the dendritic spines of Purkinje cells and their axons. PMID: 15116392
  3. Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity. PMID: 18480293
Subcellular Location
Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse.
Protein Families
Homer family
Tissue Specificity
Expressed in the cerebellum, hippocampus, lung and thymus.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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