HOMER3

HOMER3 encodes Homer protein homolog 3, a postsynaptic scaffolding protein belonging to the Homer family. It interacts with metabotropic glutamate receptors (mGluRs) and inositol trisphosphate receptors (IP3Rs), regulating intracellular calcium signaling and synaptic plasticity.
HOMER3 is primarily expressed in the brain, particularly in hippocampal and cortical neurons. Dysregulation is linked to neuropsychiatric disorders like schizophrenia and major depressive disorder. Limited drug研发 focus exists, though its role in synaptic function suggests potential as a therapeutic target for modulating glutamatergic neurotransmission.