Recombinant Mouse Integrin alpha-IIb (Itga2b), partial

1. alphaIIb beta3 antagonist TMV-7/trimucrin prevents thrombosis with causing Fc receptor gamma-chain IIa-mediated thrombocytopenia. PMID: 28815933
2. Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin. PMID: 28954813
3. Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling. PMID: 26790499
4. platelets clearly support early steps in pulmonary metastasis via GPIIb-dependent formation of platelet-tumor-aggregates PMID: 28253287
5. ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals. PMID: 27010197
6. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. PMID: 25298035
7. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation. PMID: 24969775
8. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. PMID: 24523237
9. reduction of talin-beta3 integrin binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding PMID: 24585775
10. deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation. PMID: 24385425
11. Platelets lacking ERp57 have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation. PMID: 24030382
12. Data indicate that Pyk2 is a common signaling effector downstream of both G12/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation. PMID: 23640884
13. These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen. PMID: 23216754
14. Here we show that platelet integrin CD41 (alphaIIb), currently thought to only transiently mark fetal hematopoietic stem cells, is expressed on an adult subtype that accumulates with age. PMID: 23564910
15. identified Hic-5 as a novel and specific regulatory factor for thrombin-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice. PMID: 22812543
16. These results suggested that platelet associated anti-alphaIIbbeta3 antibodies in primary primary immune thrombocytopenia tended to recognize highly restricted regions of alphaIIb with clonality. PMID: 22730538
17. Impaired spreading on fibrinogen and clot retraction with normal levels of alpha(IIb)beta(3) was observed in Lgals1(-/-) platelets, indicating a failure in the "outside-in" signaling through this integrin. PMID: 22456341
18. Glycoprotein IIb/IIIa-targeted microbubbles specifically bind to activated platelets in vitro, allowing real-time molecular imaging of acute arterial thrombosis in a mouse model. PMID: 22647975
19. Data indicate that the inflammatory cytokines TNF-alpha and IL-1 could be key components of the endothelial cell (EC) response and alphaIIb-beta3 integrin in platelets was required for late-phase thrombus stability. PMID: 22096246
20. Only the threonine 410 gets dephosphorylated, possibly in an integrin aIIbb3-dependent manner PMID: 21645497
21. Murine CD41 is a unique marker of the earliest hematopoietic cells that emerge from the mesodermal (brachyury+) compartment and contribute first to primitive hematopoiesis and definitive hematopoiesis in the blood island region of the murine yolk sac. PMID: 21618089
22. differential and temporal expression of CD41 by hematopoietic stem cells in the distinct hematopoietic territories suggests a developmental/dynamic regulation of this marker throughout development. PMID: 21415271
23. Studies indicate that CalDAG-GEFI mediates the rapid but reversible activation of integrin alphaIIbbeta3, and the adenosine diphosphate receptor P2Y12 facilitates delayed but sustained integrin activation PMID: 20971951
24. vinculin is not required for the traditional functions of alpha(IIb) beta(3) or the platelet actin cytoskeleton PMID: 20670372
25. Studies suggest that the perturbed orientation of talin relative to the membrane in the F2 mutant would be expected to in turn perturb talin/integrin interactions. PMID: 20947017
26. The involvement of fibronectin/RGD-binding integrins including alpha3beta1 and alpha5beta1 as well as glycoprotein IIb in megakaryocyte-induced osteoblast proliferation, was examined. PMID: 20052668
27. Thrombin-stimulated PP1cgamma(-/-) platelets showed decreased alpha(IIb)beta(3) activation despite comparable levels of alpha(IIb)beta(3), PAR3, PAR4 expression and normal granule secretion. PMID: 20016849
28. important role for PI3K p110 beta in regulating the avidity of high affinity integrin alpha(IIb)beta(3) receptors, necessary for the cellular transmission of contractile forces PMID: 19940148
29. study demonstrates not only a function of integrin alphaIIbbeta3 as a noncanonical Galpha13-coupled receptor but also a new concept of Galpha13-dependent dynamic regulation of RhoA PMID: 20075254
30. Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. PMID: 11686325
31. Integrin alpha 2b is expressed in midgestation embryos at sites of hematopoietic stem cell generation and multiple lineages derive from c-kit(+)alphaIIb(+) progenitors. PMID: 11884039
32. integrin alpha(IIb)beta3 activation is induced by G12/G13 activated Gi-mediated signaling pathways PMID: 12183468
33. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. PMID: 12393529
34. The glycoprotein IIb molecule is expressed on early murine hematopoietic progenitors and regulates their numbers in sites of hematopoiesis. PMID: 12871637
35. Results suggest that CD41 expression marks the onset of primitive and definitive hematopoiesis in the murine embryo and persists as a marker of some stem and progenitor cell populations in the fetal liver and adult marrow. PMID: 12900455
36. caspase-12 participates in the development of fully functional signaling pathways linking some G-protein-coupled receptors to alphaIIbbeta3 activation. PMID: 15059849
37. integrin alpha(IIb)beta3 adhesive function is regulated by platelet FXIII and calpain PMID: 15131115
38. alpha IIb beta 3 signaling in platelets is regulated by SHIP1 and Lyn kinase PMID: 15166241
39. CD151 is essential for normal platelet function and that disruption of CD151 induced a moderate outside-in integrin alpha(IIb)beta(3) signaling defect PMID: 15226180
40. T176 I mutation, located in the N-terminal region in the W3:1-2 connecting strand of the beta-propeller, reveals the N-terminal alpha IIb domain plays an important structural role in the formation of heterodimer and is also involved in fibrinogen binding PMID: 15543332
41. A function for GPIIb on mast cells is suggested by the altered adhesion of gbIIb-/- bone marrow mast cells to fibronectin- and vitronectin-coated surfaces. GPIIb could influence the in vivo differentiation or homing of tissue mast cells. PMID: 15781330
42. the engagement of alphaIIb beta3 by the C-terminal sequence of the fibrinogen gamma-chain initiates signals that suppress subsequent fibronectin assembly by spread platelets PMID: 16051597
43. GP IIb not only mediates platelet aggregation but also triggers platelet adhesion to exposed extracellular matrices and dysfunctional endothelial cells PMID: 16103235
44. Time to half-disappearance of pro-alphaIIb (t1/2) was the same in (1) HEK293 cells transfected with (a) alphaIIb plus beta3, (b) alphaIIb alone, (c) mutant beta 3 and beta3-null megakaryocytes. PMID: 16304048
45. TSSC6 appears to regulate integrin alpha(IIb)beta(3) "outside-in" signaling events in platelets and is necessary for stability of arterial thrombi in vivo. PMID: 16720835
46. Megakaryote cells in bone marrow cells contain this antigen. PMID: 17420226
47. talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo PMID: 18086863
48. support an unsuspected role of alphaIIbbeta3/serotonin transporter(SERT)associations as well as alphaIIbbeta3 activation in control of SERT activity in vivo PMID: 18317590
49. Protein phosphatase 2Ac (alpha) can negatively regulate integrin alpha(IIb)beta(3) signaling by suppressing the ERK1/2 signaling pathway PMID: 18334487
50. interaction with alphaIIbbeta3; and, consequently, the two src-family kinases can mediate different functional responses. PMID: 18430780

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KEGG: mmu:16399

STRING: 10090.ENSMUSP00000099375

UniGene: Mm.26646