Recombinant Mouse Interleukin-1 receptor-associated kinase 3 (Irak3)

1. Study using IL-33-induced type 2 immunity signaling in a combination of cell lines, mouse models, and primary cells from mouse models reveal critical roles of IRAK-M and PIN1 in IL-33-induced type 2 immunity. Upon IL-33-induced inflammation, activated PIN1 binds to and catalyzes cis-trans isomerization of phosphorylated IRAK-M, inducing IRAK-M stabilization and nuclear translocation. PMID: 29686383
2. IRAK3 methylation may be a predictive factor in the transition from colitis to cancer. PMID: 28713897
3. IRAK-M plays a crucial role in the regulation of allergic airway inflammation by modifying the function of airway epithelia PMID: 28665693
4. Taken together, these results strongly support a role for IRAK-M in renal injury and identify IRAK-M as a possible modulator in driving an alternatively activated profibrotic macrophage phenotype in unilateral ureteral obstruction-induced chronic kidney disease. PMID: 28701510
5. polycomb recessive complex 2 repressed the IRAK-M promoter, allowing low levels of expression; following LPS stimulation, the IRAK-M promoter is derepressed, and transcription is induced to allow its expression. PMID: 28011933
6. this study shows that following Pseudomonas aeruginosa infection, IRAK-M knock-out mice have enhanced lung neutrophilic inflammation and reduced bactertial load PMID: 28120642
7. Data show that interleukin-1 receptor-associated kinase 3 (IRAK-M) is responsible for regulation of microbial colonization of tumors and STAT3 protein stability in tumor cells, leading to tumor cell proliferation. PMID: 27150039
8. IRAK-M functions to modulate inflammatory signaling pathways and is critical in maintaining immune system homeostasis in the gut. However, increased IRAK-M is associated with increased disease pathogenesis and increased cancer severity in human patients. PMID: 27939424
9. IRAK-M may also contribute to myofibroblast conversion. PMID: 26542797
10. These data demonstrate LTi cells are present in the stomach and promote lymphoid follicle formation in response to infection, but are limited by IRAK-M expression. PMID: 25603827
11. IL-7 reduced IRAK-M expression and attenuated immune tolerance induced by either LPS or CpGA PMID: 26218271
12. the results suggest that IRAK-M may be targeted by L. donovani to inhibit TLR-mediated proinflammatory response late during in vitro infection. PMID: 26140693
13. These data indicate expression of IRAK-M skews lung macrophages toward an alternatively activated profibrotic phenotype, which promotes collagen production, leading to the progression of experimental pulmonary fibrosis. PMID: 25595781
14. Our study identifies the DAP12/IRAK-M/IL-10 to be a novel molecular pathway in APCs exploited by mycobacterial pathogens, allowing infection a foothold in the lung. PMID: 24172845
15. This study illustrates how the modulation of innate immune pathways through IRAK-M influences the development of autoimmune diabetes. PMID: 24696448
16. novel findings provide new insights into the understanding of negative regulatory mechanisms of the TLR4 signaling pathway. PMID: 23872113
17. Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice. PMID: 23567778
18. IRAK-M plays an important role in alcohol-induced liver injury and IRAK-M negatively regulates the innate and possibly the adaptive immune response in the liver reacting to acute insult by alcohol. PMID: 23437317
19. debris-induced IRAK-M decreases foreign body reactions, but at the same time, the over-expression of IRAK-M may also be detrimental on local intrusion of PAMPs or bacteria PMID: 22941946
20. IRAK-M mediates TLR7-induced MEKK3-dependent second wave NFjB activation to produce inhibitory molecules PMID: 23376919
21. IRAK-M impairs host defense during pneumonia caused by a common gram-negative respiratory pathogen. PMID: 22729155
22. Along with endotoxin, bacterial sonicate is able to induce refractory tolerance in BM-DCs, and IRAK-M plays a role in modulating cell surface expression of MHC class II and CD80 and release of IL-10 during this tolerance. PMID: 22472665
23. These data suggest that IRAK-M impairs host defense during pneumococcal pneumonia at the primary site of infection at least in part by inhibiting the early immune response. PMID: 22492852
24. The upregulation of IRAK-M in macrophages is involved in the local immunosuppression around implants, and may contribute to septic and aseptic implant loosening. PMID: 21987497
25. Endotoxin tolerization in vivo blocked TLR4-driven IRAK4 phosphorylation and activation in macrophages, while increasing expression of IRAK-M, SHIP-1, A20 mRNA, and A20 protein. PMID: 21934070
26. These data identify a previously unknown function of IRAK-M :suppression of TLR7-mediated autoimmunity-and mutant IRAK-M as a previously unknown genetic risk for murine SLE. PMID: 21875872
27. Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. PMID: 21690387
28. By facilitating IRAK-M expression, DNAX-activation protein (DAP)12 functions to negatively regulate lipopolysaccharide-induced liver dendritic cell maturation. PMID: 21257958
29. Loss of IRAK-M is associated with colitis. PMID: 20848470
30. IRAK-M is bound to caspase (CASP)-6 in a complex located near the plasma membrane in resting cells, and the components of this complex redistribute to nucleus and cytoplasm after neutrophil stimulation. PMID: 21098228
31. findings indicate that systemic sepsis induces epigenetic silencing of cytokine gene expression in lung macrophages, and IRAK-M appears to be a critical mediator of this response PMID: 20585389
32. manipulation of IRAK-M levels can increase the potency of DC vaccines by enhancing their Ag-presenting function, migration, and longevity PMID: 20817880
33. these findings suggest that IRAK-M negatively regulates the alternative NFkappaB pathway in a ligand-specific manner. PMID: 19809574
34. These data suggest that the absence of IRAK-M in the hematopoietic compartment post-bone marrow transplantation enhances pulmonary host defense and mitigates alveolar macrophage sensitivity to the inhibitory effects of PGE(2 PMID: 20439918
35. IRAK-M is critical to preventing deleterious neutrophil-dependent lung injury during influenza infection of the respiratory tract. PMID: 20042589
36. Endotoxin tolerance was significantly reduced in macrophages from IRAK-M knockout mice. IRAK-M regulates TLR signaling and innate immune homeostasis. PMID: 12150927
37. induction of IRAK-M and inhibition of kinase activity of IRAK-1 are crucial to PGN-induced tolerance in macrophages PMID: 14660668
38. IRAK-M is a key regulator of the bone loss that is due to osteoclastic resorption of bone. PMID: 15809356
39. IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages in the presence of Mycobacterium tuberculosis lipoarabinomannan PMID: 16263713
40. These findings indicate that IRAK-M selectively attenuates p38 activation and inhibits innate immunity through stabilizing MKP-1. PMID: 17379480
41. IRAK-M is directly involved in the regulation of both innate and adaptive immune signaling processes, and deletion of IRAK-M enhances host anti-tumor immune response. PMID: 17477969
42. reduced expression of IRAK-1 and increased expression of IRAK-M after CpG DNA pretreatment resulted in the hyporesponsiveness of macrophages that leads to the protection of mice from hepatic injury and death caused by CpG DNA/D-GalN. PMID: 18378686
43. Tolerance to intraluminally administered LPS in the lymphocyte recruitment process was induced by enterobacteria, possibly via the induction of IRAK-M and TGF-beta. PMID: 19225984
44. The expression of IRAK-M as a negative regulator of TLR7 signaling was markedly augmented in immune tolerant macrophage-like cells while the interleukin-1 receptor-associated kinase (IRAK)-1 functioned normally. PMID: 19251253
45. IRAK-M is a major mediator of globular adiponectin-induced endotoxin tolerance in primary macrophages PMID: 19414798
46. TREM-1 activation beneficially impacts pulmonary IRAK-M expression PMID: 19596984

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KEGG: mmu:73914

STRING: 10090.ENSMUSP00000020448

UniGene: Mm.146194