Recombinant Mouse Interleukin-17 receptor B (Il17rb), partial

Code CSB-YP872844MO
MSDS
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Source Yeast
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Code CSB-EP872844MO
MSDS
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Source E.coli
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Code CSB-EP872844MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP872844MO
MSDS
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Source Baculovirus
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Code CSB-MP872844MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Il17rb
Uniprot No.
Alternative Names
Il17rb; Evi27; Il17br; Interleukin-17 receptor B; IL-17 receptor B; IL-17RB; IL-17 receptor homolog 1; IL-17ER; IL-17Rh1; IL17Rh1; Interleukin-17B receptor; IL-17B receptor
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Gene References into Functions
  1. IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease PMID: 24407884
  2. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
  3. data establish IL-25 and its receptor IL-17RB as targets for innate and adaptive immune responses in chronic allergic airway disease and identify T2M cells as a new steroid-resistant cell population PMID: 22543263
  4. IL-25-mediated activities require both IL-17RB and IL-17RA in this example of an IL-17 family ligand that utilizes a heteromeric receptor complex. PMID: 18768888
  5. Results identify a novel subset of natural killer T cells that expresses the interleukin 17 receptor B (IL-17RB) for IL-25 and is essential for the induction of the airway hypersensitive reaction. PMID: 19015310
  6. IL-17RB(+) iNKT cells were detected in the lungs of wild-type mice, and induction of airway hyperreactivity by intranasal administration of IL-25 was significantly impaired in iNKT cell-deficient mice PMID: 19342692
  7. IL-17RB-positive cells in the bone marrow also express CD11B, GR1, and c-kit, potentially suggesting a maturation of the bone marrow cell once it enters the inflamed lung. PMID: 19828636

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Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Tissue Specificity
Liver and testis. Expressed at lower level in kidney and lung. Expressed in selected T-cell, B-cell and myeloid cell lines.
Database Links
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