Recombinant Mouse LIM homeobox transcription factor 1-beta (Lmx1b)

1. Authors conclude that Lmx1b plays a key role as an anti-osteogenic factor in patterning the head mesenchyme into areas with different osteogenic competence. In turn, this patterning event is crucial to generating the proper organization of the bones and soft tissue joints of the calvaria. PMID: 29852132
2. Data show that sustained expression of Lmx1a and Lmx1b is required for the survival of adult midbrain dopaminergic neurons. PMID: 27407143
3. Lmx1b is required for the topographical organization of dopaminergic innervation in the striatum.Lmx1b regulates Plxnc1 expression. PMID: 29038581
4. This is the first report to describe genome-wide Lmx1b binding during limb development. PMID: 28455377
5. Otx2 critically depends on Lmx1b for the formation of mdDA neurons. PMID: 26444681
6. results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing. PMID: 25834049
7. Co-immunoprecipitation experiments show that both wild-type and Icst LMX1B are found in complexes with LIM domain binding protein 1 (LDB1), resulting in lower levels of functional LMX1B in Icst heterozygotes than null heterozygotes PMID: 24809698
8. We posit that microRNA modulation of the Lmx1b/Wnt axis in the early midbrain/isthmus could determine midbrain size and allocation of dopamine progenitors. PMID: 24348261
9. Cell biological and biophysical experiments with primary podocytes isolated after 1 week of Lmx1b inactivation indicated dysregulation of actin cytoskeleton organization PMID: 23990680
10. Lmx1b, a key transcription factor for the specification of 5-HT and dopaminergic transmitter phenotypes during embryogenesis, determines some peptide phenotypes in these neurons as well. PMID: 23532063
11. Data indicate that tryptophan hydroxylase 2 Tph2-/- and LIM homeobox transcription factor 1 beta Lmx1b-/- females displayed a change in sexual preference. PMID: 23716677
12. A protein complex was identified containing PSPC1, PSF and LMX1B, suggesting the existence of this complex in mesodiencephalic dopaminergic neurons. PMID: 23308148
13. Lmx1b genes are associated with skeletal development. PMID: 22417325
14. This study demonistrated that Lmx1b promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex PMID: 22397680
15. This study demonstrated that Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of mDA progenitors, including their floor plate-like properties. PMID: 21880902
16. data establish that Lmx1b influences the differentiation of multiple neuronal subtypes in the ventral midbrain, whereas Lmx1a appears to be exclusively devoted to the differentiation of the dopamine neuron lineage PMID: 21752929
17. report 14 genes that require Lmx1b for their normal expression in the dorsal limb or the restriction of their expression to the ventral limb. PMID: 20589901
18. link a specific transcription factor Lmx1b to trabecular meshwork formation and demonstrate specific requirements for Lmx1b in maintaining the integrity of adult anterior segment. PMID: 20568247
19. In Lmx1b knockout ((-)(/)(-)) mice, V primary afferent projections to PrV are normal, albeit reduced in number, whereas the PrV-thalamic lemniscal pathway is sparse and develops late. PMID: 20621716
20. obtained evidence that Lmx1a and Lmx1b cooperate with Foxa2 to specify mesDA neuron identity by gain-of-function approaches using transgenic mice PMID: 20035737
21. Results indicate that whereas Lmx1b activity is required autonomously in skeletal progenitors to direct dorsal pattern, loss or gain of Lmx1b activity in skeletal progenitors has no effect on muscle or connective tissue patterning. PMID: 20215352
22. When Lmx1b expression is deleted at the dorsal midline, Lmx1b/Lmx1a-null mutants fail to generate a hindbrain roof plate. PMID: 19741143
23. Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation. PMID: 11956244
24. The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes PMID: 11956245
25. Review. Studies of Lmx1b knockout mice show it is a transactivator required for coordinate expression of Col4a3 and Col4a4, and other podocyte function genes. PMID: 11978876
26. During development of 5-HT neurons, Lmx1b is a critical intermediate factor that couples early specification with nerve terminal differentiation. PMID: 12897786
27. Ectopic expression of Lmx1b plus Pet-1 is able to induce formation of 5-HT cells in the most ventral spinal cord, where Nkx2.2 is normally expressed. Combined expression of Lmx1b, Pet-1, and Nkx2.2, drives 5-HT differentiation in the dorsal spinal cord PMID: 14602809
28. Myogenic precursors in limb bud were devoid of Lmx1b expression. Lmx1b is not only expressed at early stages of limb development but maintains its pattern, at least until after birth. New details of Lmx1b expression on cellular basis within limb. PMID: 15007643
29. Lmx1b expression localized to dorsal joint-forming regions, to developing tendons and ligaments PMID: 15183306
30. data identify Lmx1b as a key regulator of spinal cord roof plate induction and function PMID: 15215291
31. Results indicate that Lmx1b has a pivotal role in genetic cascades that control the assembly of circuitry in the superficial dorsal horn. PMID: 15229182
32. Lmx1b is required for the differentiation and migration of neurons within the dorsal spinal cord. The inability of afferent sensory neurons to migrate into the dorsal horn is entirely consistent with diminished pain responses in nail patella syndrome PMID: 15562281
33. A critical role is revealed for Lmx1b in maintaining the differentiated status of serotonergic (5-HT) neurons in conditional knock-out Lmx1bf/f/p mice compared with wild-type mice. PMID: 17151281
34. Lmx1b plays an essential role in the development of the tectum and cerebellum by regulating expression of Fgf8, Wnt1 and several isthmus-related transcription factors in the midbrain-hindbrain boundary PMID: 17166916
35. The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes PMID: 17316599
36. First report of a phenotype in heterozygous Lmx1b (Lmx1b+/-) knockout animals. PMID: 17657578
37. Results suggest that LMX1B controls different targets along the proximal-distal axis of the limb, and suggest the existence of a dorsal proximal limb region that is rich in mRNAs requiring Lmx1b for their expression. PMID: 18351676
38. Lmx1b is involved in the postnatal maturation of certain types of neurons and maintenance of their normal functions in the adult brain. PMID: 18512225
39. expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b, En1, Pax2, Pax5, Sox1, Sox2, and Wnt1), and also the number of neural stem cells (NSC) derived from D3mshM6A cells PMID: 18522499
40. These data demonstrate for the first time that LMX1B directly regulates transcription of a subset of NF-kappaB target genes in cooperation with nuclear p50/p65 NF-kappaB. PMID: 18996370
41. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development PMID: 19607821

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KEGG: mmu:16917

STRING: 10090.ENSMUSP00000043616

UniGene: Mm.39825