Recombinant Mouse Long-chain fatty acid transport protein 1 (Slc27a1), partial

1. this study shows that FATP1 regulates the production of inflammatory cytokines through ceramide and the c-Jun N-terminal kinase signaling pathway PMID: 29272817
2. Macrophage Fatp1 limits atherogenesis in LDL receptor knockout mice. PMID: 29035781
3. our results suggest that FATP1 localized at the basal membrane of brain microvessels contributes to the transport of docosahexaenoic acid, taurine and biotin into the brain PMID: 28035674
4. MicroRNA-199a targets FATP1 and inhibits the adipogenic transdifferentiation of cultured myoblasts. PMID: 27562723
5. These results suggest that n-3 polyunsaturated fatty acids could improve lipid oxidation-related enzymes in liver subjected to hemorrhagic shock/resuscitation. PMID: 27110821
6. Transgenic expression of FATP1 in suprabasal keratinocytes rescued the phenotype of Fatp4 mutants, and FATP1 sorted to the same intracellular organelles as endogenous FATP4 PMID: 25184958
7. FATP1 was localized in mitochondria, in the outer membrane and intermembrane parts, of mouse skeletal muscle PMID: 24858472
8. Fatp1 deficiency affects retinal light response and dark adaptation, and induces age-related alterations. PMID: 23166839
9. Overexpression of Fatp1 in skeletal muscle increased the rate of long-chain fatty acid transport and channelled these lipids to oxidation, not to intramuscular lipid accumulation. PMID: 21442160
10. FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase PMID: 20356843
11. The FATP1 enhanced the activity of 2-oxoglutarate dehydrogenase independently of its acyl-CoA synthetase activity whereas silencing of FATP1 in 3T3-L1 adipocytes resulted in decreased activity of 2-oxoglutarate dehydrogenase. PMID: 19535819
12. FATP1, like FAT/CD36, is associated with mitochondria and has a role in mitochondrial oxidation of fatty acids. PMID: 19429947
13. Insulin causes fatty acid transport protein translocation PMID: 11970897
14. FATP1 homodimeric complexes play an important role in cellular fatty acid import. PMID: 12533547
15. murine fatty acid transport protein 1 has Acyl-CoA synthetase activity PMID: 12937175
16. FATP1 has a role in insulin resistance and intramuscular accumulation of fatty acyl-CoA PMID: 14991074
17. In MHC-FATP mice, increased cardiac myocyte FATP1 overexpression increases uptake in the setting of normal plasma substrate concentrations, providing the 1st demonstration that FATP1 overexpression augments FFA tissue import & causes cardiomyopathy. PMID: 15618539
18. the different mmFATP isoforms play unique roles in fatty acid trafficking, including the transport of exogenous long-chain fatty acids PMID: 15699031
19. Together, our findings suggest that a constitutive interaction between FATP1 and ACSL1 contributes to the efficient cellular uptake of LCFAs in adipocytes through vectorial acylation. PMID: 16357361
20. Insulin-stimulated fatty acid uptake is completely abolished in FATP1-null adipocytes and greatly reduced in skeletal muscle. PMID: 16611988
21. Stimulation of fatty uptake by isoproterenol required both protein kinase A and mitogen-activated kinase signaling and is completely dependent on FATP1 expression. PMID: 17130465
22. PPARgamma, even in the absence of exogenous activators, is required for normal rates of fatty acid uptake in oxidative skeletal muscle via mechanisms independent of AMPK and fatty acid transport protein 1. PMID: 18653710
23. fatty acid influx mediated by FATP1 regulates AMPK and provides a potential regulatory mechanism for balancing de novo production of fatty acids from glucose metabolism with influx of preformed fatty acids via phosphorylation of acetyl-CoA carboxylase. PMID: 19560442

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KEGG: mmu:26457

STRING: 10090.ENSMUSP00000034267

UniGene: Mm.38165