Recombinant Mouse Lymphocyte antigen 6A-2/6E-1 (Ly6a)

1. In early stages, overexpression of Sca-1 decreases tumour formation while at later stages overexpression of Sca-1 seems to drive tumours towards malignant progression. PMID: 28732240
2. Sca-1 is a novel cancer stem cells enrichment marker. PMID: 26869189
3. IL-27-induced Sca-1(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes and Blimp1. PMID: 28758191
4. SCA-1 enriches for an ERalpha(+), estrogen-sensitive subpopulation within the CD24(+)/CD49f(hi) MaSC population that may be responsible for the hormonal sensitivity of the developing mammary gland. PMID: 28132885
5. Upregulation of leptin levels in both the vessel wall and the circulation after vessel injury promoted the migration of Sca-1(+) progenitor cells via leptin receptor-dependent signal transducer and activator of transcription 3- Rac1/Cdc42-ERK (extracellular signal-regulated kinase)-FAK pathways, which enhanced neointimal formation. PMID: 28935755
6. Both the number of lung CD31-CD45-Sca-1+ cells and the expression levels of the Shh signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh signaling pathway are reactivated during acute adenovirus infection. PMID: 28352167
7. we report significantly higher expression of the immunoglobulin light chain by B cells in lamina propria of Ly-6A/Sca-1deficient mice when compared to the wild-type control. PMID: 27322740
8. c-Myb regulates proliferation/differentiation of adventitial Sca1+ vascular smooth muscle progenitor cells by transcriptional activation of myocardin. PMID: 27174098
9. sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model. PMID: 27666446
10. Results indicate that IL-17A promotes tumorigenicity of colon cancer cells by enhancing cell cycle progression and directly induces the expression of Sca-1. PMID: 27378226
11. Study provides evidence that up-regulation of miRNA-21 can promote migration and proliferation of Sca-1+ CSCs to enhance the capacity of Sca-1+ CSCs to repair damaged myocardium. PMID: 27210794
12. the androgen-independent and bipotent organoid-forming Sca-1(+) luminal cells as a functionally distinct cellular entity, is reported. PMID: 26418304
13. Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and beta-catenin signaling pathways. PMID: 27066979
14. Data show that bisperoxovanadium (BpV) treatment induces specific epigenetic modifications at the promoter regions of genes associated with stem cell fate, including Sca-1 and Pw1. PMID: 26672000
15. The results suggested that the depletion of the progenitor cell pool and DNA methylation of Sca-1 gene may be involved in the progression of emphysema in mice. PMID: 26264445
16. PDGFRalpha has a role in demarcating the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium PMID: 25980517
17. The progenitor phenotype of the Sp-C(+)Sca-1(+) cells that mediates alveolar epithelial repair might involve Wnt signaling. PMID: 25474582
18. Subcutaneous and visceral fat-derived Sca1(high) ASCs particularly differ in the gene expressions of adhesion and ECM molecules. PMID: 24726953
19. The more aggressive behavior of Ly6a/Sca-1 expressing leukemias is due at least in part to greater capacity to degrade microenvironmental stroma and invade tissues. PMID: 24586463
20. Reversal of ischemic cardiomyopathy with Sca-1+ stem cells modified with multiple growth factors. PMID: 24705272
21. Sca1 and bromodeoxyuridine positive cells may participate in the formation of new thyroid follicles after partial thyroidectomy. PMID: 24278321
22. Sca1 positive murine pituitary adenoma cells show tumor-growth advantage. PMID: 24481638
23. The high and specific expression of stem cell antigen 1 (Sca1) in TtT/GF cells was confirmed by real-time polymerase chain reaction. PMID: 23881407
24. Application of hematopoietic progenitor (lin-/sca-1+) or endothelial progenitor cells potentially improves the inflammatory and oxidative stress parameters in an atherosclerosis model. PMID: 22622053
25. the A2B receptor signaling linked to up-regulation of pro-angiogenic factors in cardiac Sca-1(+)CD31(-) stromal cells is essential for overall improvement of cardiac recovery seen after their transplantation to the injured heart. PMID: 23827818
26. Report the distribution of c-kit/Sca-1/CXCR4 expressing cardiac stem cells in the different compartments of the heart and significant reduction in their number in adult heart. PMID: 23273785
27. Sca-1(-) Plasmacytoid dendritic cells are an early developmental stage of Plasmacytoid dendritic cells with distinct innate functions representing the true murine natural IFN-alpha-producing cells. PMID: 23922217
28. These results demonstrate that TLR4/Sca-1 signaling plays an important role in the regulation of hematopoietic precursor cell programming and their enhancement of granulocyte lineage commitment in response to E. coli bacteremia. PMID: 23545304
29. PECAM1(+)/Sca1(+)/CD38(+) vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. PMID: 23308177
30. Sca-1(+) cells expressed markedly higher levels of mammary stem cell-related genes in comparison to Sca-1(-) cells. PMID: 22634533
31. Identification of a population of LY6A+ mouse ovarian surface epithelium progenitor cells on the surface of the ovary that may play a role in ovulatory wound healing. PMID: 22914315
32. results of this study suggest that increased Sca1 expression on erythropoietic precursors inhibits erythroid differentiation PMID: 23246681
33. Sca-1 protects against cardiac hypertrophy and fibrosis via regulation of multiple pathways in cardiomyocytes. PMID: 22851736
34. Data show that deletion of Sca-1 causes primary cardiac defects in myocardial contractility and repair consistent with impairment of resident cardiac progenitor cell proliferative capacity. PMID: 22800687
35. Sca-1 is either redundant or a nonessential marker of adipose progenitor/stem cells. PMID: 21510817
36. Studies suggest that the cloned Sca-1+CD45- cells confer the therapeutic benefits of Cardiospheres (CSs) in the mouse myocardial infarction (MI) model. PMID: 22272337
37. Sca-1 is a negative regulator of the tumor suppressor effects of PPARgamma PMID: 21955520
38. enhanced Sca-1 expression facilitates activation of the ERK pathway and supports the proliferation of myeloid and granulopoietic precursors during bacteremia; alcohol intoxication suppresses this response PMID: 22238460
39. MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia. PMID: 21856785
40. These data demonstrate the crucial role of Sca-1 in the maintenance of cardiac integrity and suggest that Sca-1 restrains spontaneous differentiation in the precursor population. PMID: 21957128
41. Results imply that Sca-1-positive cells may have a role in the duct cell proliferation in the regeneration step elicited by excretory duct ligation-induced injury. PMID: 21884259
42. Postulate that SCA1(+)/CD31(+) cardiac side population cells may represent endothelial progenitor cells in the mouse heart. PMID: 21615679
43. Hematopoietic lineage cells with Sca-1(high) expression and CD62L(neg/low) expression are characterized as multipotent progenitor cells, based on transient engraftment. PMID: 21998453
44. Ly6a as a candidate gene for functional involvement in novelty responsiveness PMID: 21673958
45. Inhalation of acrolein increases apoptosis and suppresses the circulating levels of Flk-1(+)/Sca-1(+) cells while increasing these cells in the bone marrow and preventing their mobilization by VEGF. PMID: 21527748
46. Sca-1 attenuated GDF10-dependent TGF-beta signaling by disrupting the heterodimerization of TbetaRI and TbetaRII receptors. PMID: 21518866
47. TGF-beta1 represses Sca-1 expression in T cells and other immune cell populations derived from the spleen, indicating that regulation by TGF-beta1 is a general feature of Sca-1 expression in multiple cell types PMID: 21156809
48. Sca-1-/- mice have a defect in their capacity to recruit soluble IgM, and subsequently C3 complement, to damaged muscle. There was a significant reduction in B-1a cells in Sca-1-/- mice. PMID: 21123737
49. Prior exposure of mesenchymal stem cells to hypoxia led to a significant reduction of ex vivo expansion time, with significantly increased numbers of Sca-1(+) as well as Sca-1(+)/CD44(+)double-positive cells. PMID: 20496083
50. Ly-6C(hi) monocytosis disturbs resolution of inflammation in murine infarcts and consequently enhances left ventricular remodeling. PMID: 20378083

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KEGG: mmu:110454

STRING: 10090.ENSMUSP00000023248

UniGene: Mm.425949