Recombinant Mouse Metabotropic glutamate receptor 2 (Grm2), partial

1. Here we show that glutamate signals through metabotropic glutamate receptor 2 (mGluR2) to induce Erk phosphorylation in SC. mGluR2-elicited Erk phosphorylation requires ErbB2/3 receptor tyrosine kinase phosphorylation to limit the signaling cascade that promotes phosphorylation of Erk, but not Akt. PMID: 27432639
2. activation of mGlu2 receptors is detrimental in the post-ischemic phase, and support the use of mGlu2 receptor antagonists in the experimental treatment of brain ischemia. PMID: 28821279
3. mGlu2 activation exerts effects on striatal physiology that extend beyond modulation of corticostriatal synapses, and has the potential to influence cognition and striatum-related disorders via inhibition of thalamus-derived glutamate and dopamine release. PMID: 28159646
4. These studies provide a foundation for future research seeking to parse out the roles of mGlu2 from mGlu3, paving the way for better understanding of how these receptors regulate activity in the brain. PMID: 27818290
5. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. PMID: 26758213
6. provided evidence that JARID1B via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB PMID: 25950516
7. Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2+) transients and striatal field potentials. PMID: 25781000
8. In GRM2 knockout mice motor coordination and cognition is unchanged compared to GRM2/3 double knockout mice. PMID: 25158312
9. activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission PMID: 23558090
10. The findings support the possibility that interactions between mGlu2/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders PMID: 24053122
11. mGluR3 knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 receptors are critical in mediating addictive-like behavior. PMID: 23624743
12. In the central nervous system, mGluR2 and mGluR4 form a hetero-complex with a distinct pharmacological profile. PMID: 24381270
13. The reduction in the expression of mGluR2 and mGluR3 may be involved in the development of benzodiazepine dependence. PMID: 23392308
14. 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex. PMID: 23508685
15. The mGluR2 subtype activates an inwardly rectifying potassium conductance in dendrites of the dentate gyrus. PMID: 23616537
16. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. PMID: 23382250
17. Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A. PMID: 23129762
18. Restraint stress induces a schizophrenia-like phenotype in mice, with epigenetic changes in mGlu2 and mGlu3 receptors that lie at the core of pathological programming induced by early-life stress. PMID: 22089319
19. Fractionation of hippocampus-dependent memory depending on the appetitive-aversive context is to our knowledge unique, and suggests a role for group II metabotropic GluRs at the interface of arousal and cognition. PMID: 21832989
20. Isolation rearing causes an increase in mGluR2 receptors in prefrontal cortex and hippocampus. PMID: 20970439
21. Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice. PMID: 21360593
22. Data show a significant reduction of the inward current in mGluR3(-/-) but not in mGluR2(-/-) mice. PMID: 21628565
23. Formation of a 5-serotonin 5-HT2A receptor (HT2AR)-mGluR2 complex suggests a functional interaction that affects the hallucinogen-regulated cellular signaling pathways. PMID: 21276828
24. Report activity of mGlu2/3 receptor agonist in memantine-induced brain activation. PMID: 21057775
25. In frontal cortex of mice born to influenza virus-infected mothers, the 5-HT(2A) receptor is upregulated and the mGlu(2) receptor is downregulated, an alteration that may be involved in the behavioral changes observed. PMID: 21289196
26. partial, but highly significant, loss of mGlur2 receptors in amyloid-affected discrete brain regions of Alzheimer cases and PS2APP mice PMID: 20875805
27. Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex. PMID: 11805343
28. Constitutively active Galphai2 occludes the transient suppression of synaptic transmission by mGluR2. PMID: 16606834
29. MGlu2 is regulated by the NF-kappaB transcriptional machinery; agents that increase acetylation and activation of NF-kappaB transcription factors induce analgesia via upregulation of mGlu2 in DRG neurons. PMID: 16764720
30. Kainate receptors activation interferes with the depression of glutamate release produced by Group II metabotropic glutamate receptor stimulation PMID: 17510730
31. 2AR and mGluR2, but not mGluR3, are co-expressed in cortical neurons PMID: 18297054
32. In the hippocampus of mGluR2 knockout mice, there is a compensatory upregulation of other glutamate receptors and a downregulation of glutamate transporter expression. PMID: 18720515
33. major role played by the dentate gyrus and CA3 areas in the early phases of contextual memory processing through MGLUR2 AND MGLUR3 PMID: 19638469

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KEGG: mmu:108068

STRING: 10090.ENSMUSP00000023959

UniGene: Mm.410822