Recombinant Mouse NACHT, LRR and PYD domains-containing protein 6 (Nlrp6), partial

1. Clostridium butyricum may exert a beneficial action on visceral hypersensitivity of irritable bowel syndrome (IBS) by inhibiting low grade inflammation of colonic mucous through its action on nod-like receptor pyrin domain-containing protein 6 (NLRP6). PMID: 29329362
2. NLRP6 is important for suppressing the development of spontaneous colitis in the Il10 (-/-) inflammatory bowel disease model and NLRP6 deficiency results in the enrichment of Akkermansia muciniphila. PMID: 28445725
3. these data reveal a previously unappreciated role for NLRP6 in inflammatory monocytes, which are recruited after dextran sodium sulfate-induced intestinal injury to promote barrier function and limit bacteria-driven inflammation PMID: 27353251
4. this study shows that Nlrp6-dependent Inflammasomes do not shape the commensal gut microbiota composition PMID: 28801232
5. this review discuss recent findings related to NLRP6 activity, while highlighting outstanding questions and future perspectives in elucidating its roles in health and disease PMID: 28214100
6. Study identified a set of microbiota-modulated metabolites whose integrative activity drives NLRP6 inflammasome activation and downstream epithelial IL-18-induced anti-microbial peptide secretion, thereby providing favorable conditions for WT microbiota colonization. PMID: 26638072
7. Nlrp6 contributes to recovery from peripheral nerve injury by dampening inflammatory responses independently of IL-1beta and inflammasomes PMID: 26253422
8. These data demonstrate that Nlrp6 functions with Dhx15 as a viral RNA sensor to induce IFN-stimulated genes , and this effect is especially important in the intestinal tract. PMID: 26494172
9. Study demonstrates that NLRP6 is important in maintaining autophagy in the intestinal epithelium, a process previously shown to be critically important in intestinal granule exocytosis pathway. PMID: 24581500
10. Exposure of mice to stress inhibits NLRP6 and alters the composition of the gut microbiota, leading to intestinal inflammation. PMID: 23470617
11. Studies identify AVR/NAVR as key receptors involved in blood pressure regulation and sex-specific modulation of renal water homeostasis, cognitive function, and anxiety-like behavior. PMID: 20923861
12. AVR is distinct from Nalp6/PYPAF5 based on different mRNA and protein sizes, subcellular localization, and tissue-specific expression patterns. PMID: 18413781
13. The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model. PMID: 11984003
14. This publication deals with the rat ortholog of the mouse Nlrp6 gene. PMID: 7489366
15. results reveal NLRP6 as a negative regulator of inflammatory signalling, and demonstrate a role for this NLR in impeding clearance of both Gram-positive and -negative bacterial pathogens PMID: 22763455
16. NLRp6 function in maintaining intestinal homeostasis to prevent the development of aberrant inflammation and tumor development within the colon. PMID: 21543645
17. Data show that absence of NLRP6 accelerated colitis-associated tumor growth in mice. PMID: 21593405
18. Study shows that deficiency of NLRP6 in mouse colonic epithelial cells reduces IL-18 levels & altered fecal microbiota with expanded bacterial phyla Prevotellaceae & TM7; this altered microbiota is associated with a colitogenic phenotype. PMID: 21565393

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KEGG: mmu:101613

STRING: 10090.ENSMUSP00000101660

UniGene: Mm.386833