Recombinant Mouse Neurotrophin-3(Ntf3)

Code CSB-YP016120MO
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Source Yeast
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Code CSB-EP016120MO
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Source E.coli
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Code CSB-EP016120MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP016120MO
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Source Baculovirus
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Code CSB-MP016120MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ntf3
Uniprot No. P20181
Alternative Names Ntf3; Ntf-3; Neurotrophin-3; NT-3; HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor
Species Mus musculus (Mouse)
Expression Region 140-258
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Seems to promote the survival of visceral and proprioceptive sensory neurons.
Gene References into Functions
  1. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. PMID: 29549646
  2. NT-3 modulates both synaptic transmission and plasticity in the striatum; nonetheless, synaptic plasticity was modified by 3-nitropropionic acid treatment, where instead of producing striatal long-term depression (LTD), long-term potentiation (LTP) was obtained. Moreover, the administration of NT-3 in the recording bath restored the plasticity observed under control conditions (LTD) in this model of striatal degeneration. PMID: 29453932
  3. studies for the first time have shown that NT-3 increases muscle fiber diameter in the neurogenic muscle through direct activation of mTOR pathway and that the fiber size increase is more prominent for fast twitch glycolytic fibers PMID: 29523879
  4. that the NT3-TrkA complex uses Ras/MAPK and/or PI3K-AKT signaling to induce axon growth and inhibit axon branching along intermediate targets PMID: 28461220
  5. NT-3-transduced bone marrow- derived neural stem cells differentiated into a greater number of cholinergic neurons. PMID: 27720999
  6. Ntf3, but not Bdnf, expression by postnatal supporting cells regulates cochlear function. PMID: 25329343
  7. Study shows that dissociated cochlear nucleus neurons can be stimulated by neurotrophic factors BDNF, NT-3, and FGF2 PMID: 24978398
  8. Data show that acteoside can up-regulate the expression of brain neurotrophin-3 (NT-3) in D-galactose combined with aluminum trichloride treated mice. PMID: 25270201
  9. CAPS2 plays an important role in subcellular locality (axonal vs. somato-dendritic) of enhanced BDNF and NT-3 release, which is indispensable for proper development of postnatal cerebellum. PMID: 24923991
  10. Uptake of NT-3 from irrigating vasculature and cerebrospinal fluid induces the rapid phosphorylation of endothelial nitric oxide PMID: 25043422
  11. Loss of Ntf3, by contrast, causes an increase in layer VI neurons but does not rescue the Sip1 mutant phenotype, implying that other parallel pathways also control the timing of progenitor cell fate switch. PMID: 25085976
  12. it was PDGF, NT-3 and IGF-2 in combination that conducted the transdifferentiation PMID: 24454677
  13. NT3 is involved in the laminar formation of the developing cerebral cortex through the intercellular MEK/ERK pathway. PMID: 24190235
  14. This study demonistrated that NT-3(-/-) mutants had 65% fewer TG neurons than found in age-matched wild-type (WT) mice. PMID: 23614607
  15. Although microstructural analysis did not reveal a decrease in the rate of decay of eating in smooth muscle-specific-NT-3(KO) mice, they ate continuously during the 30-min meal, whereas controls terminated feeding PMID: 24068045
  16. Data indicate that BDNF, NT3 and NT4 trophic factors were detected in the conditioned medium of both wild-type and Friedreich's ataxia YG8 stem cells. PMID: 23671637
  17. Data indicate that calcineurin regulates levels of STAT3 and neurotrophin dependence. PMID: 23733189
  18. This study indicates that excessive NT-3 from astrocytes contributes to the abnormal neuronal dendritic development and that astrocytes could be a potential therapeutic target for Fragile X syndrome . PMID: 23300470
  19. This study demonistrated that neurotrophin-3 trafficking in the adult olfactory system. PMID: 23261763
  20. We conclude that upregulation of NT-3 in neonatally wounded skin is a critical factor mediating the sensory nerve sprouting that underlies hypersensitivity and pain following skin injury. PMID: 22871470
  21. We find that the expression of many proprioceptor-enriched genes is dramatically altered by genetic NT3 elimination, independent of survival-related activities. PMID: 23029089
  22. present study demonstrates that DIO mice show impairment of both hippocampus-dependent contextual and amygdala-dependent cued responses in the fear-conditioning tests, as well as an imbalance in the interaction between the BDNF and NT-3 systems in brain PMID: 22487415
  23. the motoneuron is a functional source of Ntf3 and motoneuron-derived Ntf3 is an essential pre-target neurotrophin for survival and axonal projection of sensory neurons. PMID: 22318233
  24. This study demonistrated that NT-3-triggered wave of cell mitosis after birth is specific for the retinal dopamine cells in mice. PMID: 21880927
  25. regular rhythms of BDNF and NT-3 are essential for correct cortical network formation in juvenile rodents PMID: 21527636
  26. Results suggest that proneurotrophin-3 and proBDNF may play important roles in the response to noise-induced injuries or ototoxic damage via the Sortilin:p75(NTR) death-signalling complex. PMID: 21261755
  27. Demonstrate for the first time that neurotrophin-3 (NT-3) regulates the development of physiological properties of ON-OFF center RGCs. PMID: 20975932
  28. Knockdown of Dok6 decreased neurite outgrowth in cortical neurons upon neurotrophin 3 stimulation. PMID: 20565848
  29. NT-3 expression in the GI tract is largely restricted to smooth muscle at ages when vagal axons grow into the GI tract. PMID: 20387078
  30. Report the proangiogenic capacity of NT-3 and propose NT-3 as a novel potential agent for the treatment of ischemic disease. PMID: 20360537
  31. These results demonstrate that DNA methylation and/or histone modification regulate BDNF gene expression, but do not regulate NT-3 gene expression in Neuro-2a cells. PMID: 20188708
  32. The results indicate that a reduction in NT-3 availability during development impairs motor nerve terminal maturation and synaptic vesicle recycling and leads to a reduction in muscle fiber diameter. PMID: 20092553
  33. NT-3 has a role in the developmental mechanism that eliminates redundant synapses though it cannot modulate synaptic transmission locally as the NMJ matures. PMID: 20178830
  34. NT-3 and BDNF exert a profound effect on the types of neurotransmitter receptors expressed on postnatal SGN. PMID: 19778585
  35. NT3 is expressed in the mouse cochlear nucleus by around post-natal day 8 and peaks around d30. NT3 immunostatin was axonal and perisomatic. PMID: 19610111
  36. increases in proprioceptive sensory neurons, spindles and gamma motoneurons, along with continued postnatal neurotrophin 3 overexpression in muscle significantly disrupt normal locomotor control PMID: 11794730
  37. overexpression of NT-3 in muscle significantly reduced neuronal loss following injury PMID: 11810635
  38. promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals PMID: 11848682
  39. detected NT-3 and NT-4/5 in alveolar macrophages,and in lung homogenates; a previously unknown trafficking signal occurs through neurotrophins in peripheral lung PMID: 12122447
  40. Neurotrophin-3 knockout mice exhibit a reduction of axonal bundles projecting from thalamus through cortical white matter, implicating neurotrophins in the critical stage of precise thalamocortical connections. PMID: 12441052
  41. The presence of neurotrophin 3 in supporting cells in the normal and degenerating cochlea indicates their role in the sustenance of inner hair cells PMID: 12485622
  42. Results describe replacement of the coding part of the brain-derived neurotrophic factor gene (BDNF) in mice with that of neurotrophin 3 (NT3) to analyse the specificity and selective roles of BDNF and NT3 during development. PMID: 12620975
  43. NT3-dependent neurons in mice survived and expressed the proprioceptive neuronal marker parvalbumin. Initial extension and collateralization of proprioceptive axons occurred normally, but they extended only as far as the intermediate spinal cord. PMID: 12741988
  44. Increased expression of nt-3 in the mechanically compressed spinal cord of the spinal hyperostotic mouse (twy/twy). PMID: 12774239
  45. During embryonic and postnatal development, beta-galactosidase is detected in the olfactory system, in the nasal epithelium and in the olfactory bulb; the expression of beta-galactosidase faithfully mimics the expression of neurotrophin-3. PMID: 12815759
  46. neurotrophin-3, through its receptor TrkC, plays a critical role in regulating the Th1/Th2 balance PMID: 12941481
  47. Esophageal intraganglionic laminar endings share neurotrophin dependence on NT-3 with spinal proprioceptors and some cutaneous mechanosensors, in concurrence with their proposed function as vagal mechanosensors crucial for reflex peristalsis. PMID: 14614961
  48. NT3 expressed temporally and spatially in the place of BDNF is sufficient in some neuronal populations to compensate for the loss of BDNF in BDNF-/- knockout mice. PMID: 14625444
  49. NT-3 signaling is not required for the differentiation of Merkel cells, but it is essential for their postnatal survival PMID: 14648839
  50. In a primary olfactory neuronal culture, NT-3 is found to activate the phosphatidylinositol 3-kinase/Akt pathway directly and to activate the MAP kinase and phospholipase C pathways indirectly. PMID: 14697654

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Subcellular Location Secreted.
Protein Families NGF-beta family
Tissue Specificity Brain and peripheral tissues.
Database Links

KEGG: mmu:18205

STRING: 10090.ENSMUSP00000107863

UniGene: Mm.267570

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