Recombinant Mouse Nibrin (Nbn)

1. Loss of Nbn expression is associated with premature hair loss. PMID: 27050272
2. the essential role of Nbs1 is via its interaction with Mre11 and that most of the Nbs1 protein is dispensable for Mre11 complex functions and suggest that Mre11 and Rad50 directly activate ATM. PMID: 28076792
3. Low NBS1 expression is associated with B-cell lymphomas. PMID: 28819025
4. Phosphorylation status of NBS1 determines how dysfunctional telomeres are repaired. PMID: 28216226
5. findings show that NBS1 is crucial for macrophage function during normal aging PMID: 26324700
6. TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 or by elimination of the ATM-effector kinase CHK2 PMID: 25768017
7. In the absence of wild type nibrin, the repair of spontaneous errors, presumably arising during DNA replication, makes a major contribution to the basal mutation rate. PMID: 25771721
8. Nbs1 mutants initially accumulate replication intermediate, not DSBs. PMID: 24388752
9. This report showed that ATM-Chk2-P53 signaling pathway and the AKT/mTOR signaling pathway are responsible for the enhanced apoptosis of the Nbn-deficient mature oligodendrocytes. PMID: 24272708
10. JNK signaling and ATR signaling are likely to converge to regulate the cerebellar apoptosis of newborn Nbn-deficient mice. PMID: 23934213
11. Nbn and Atm collaborate to prevent DSB accumulation and apoptosis during development in a tissue- and developmental stage-specific manner. PMID: 23935957
12. the antagonism and redundancy of ATMIN and NBS1 constitute a crucial regulatory mechanism for ATM signaling and function. PMID: 23219553
13. Nbs1-deficient neocortex shows accumulative endogenous DNA damage and defective activation of Ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway upon DNA damage. PMID: 22212482
14. NBS1 haploinsufficiency results in increased mammary tumor latency and metastasis. PMID: 22576691
15. a distinct function of Nbs1 and Atr in neurogenesis PMID: 22078264
16. murine cells have evolved mechanisms to ensure the functional redundancy of Pif1 or Nbs1 in the regulation of chromosome healing. PMID: 21945094
17. Atm has cellular roles not regulated by Nbs1 in the murine cerebellum. PMID: 21300797
18. deletion of the entire Nbs1 protein in T-cell precursors (Nbs1(T-del)) results in severe lymphopenia and a hindrance to the double-negative 3 (DN3)-to-DN4 transition in early T-cell development PMID: 20921278
19. Study concludes that Nbs1 and Rad54 function cooperatively, but in separate pathways to counteract DNA double-strand break. PMID: 19782649
20. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. PMID: 19910469
21. Atm and NBS1 function in overlapping as well as distinct pathways in regulating cellular response to DNA damage and animal development. PMID: 11889050
22. murine model of Nijmegen breakage syndrome, the Nbs1(DeltaB/DeltaB) mouse PMID: 11967151
23. Gamma-irradiation enhanced tumor development in Nbn(+/-) mice, giving rise to a high frequency of epithelial tumors, mostly in the thyroid and lung, as well as lymphomas. PMID: 14612522
24. Data show that NBS1, H2AX, and p53 play synergistic roles in ATM-dependent DNA damage responses and tumor suppression PMID: 15632067
25. Nibrin plays a role in the repair of gamma-irradiation damage, maintenance of chromosomal stability, and the recombination of Ig constant region genes in B lymphocytes. PMID: 15668383
26. Nbs1 is critical for efficient Ig class-switch recombination and maintenance of the integrity of chromosomal structure and number. PMID: 15668392
27. Nbs1 is a novel p53-independent Mdm2 binding protein and links Mdm2 to the Mre11-Nbs1-Rad50-regulated DNA repair response PMID: 15734743
28. Inactivation of the Nbn gene in neural tissues results in a combination of the neurological anomalies characteristic of Nijmegen breakage syndrome, ataxia telangiectasia and ATLD, including microcephaly, growth retardation, cerebellar defects and ataxia. PMID: 15821748
29. overexpression of NBS1 is an oncogenic event that contributes to transformation through the activation of PI3-kinase/Akt PMID: 16036916
30. Nbs1 functions in terminal differentiation of the lens fibre cells and in cataractogenesis. PMID: 16790366
31. Cells lacking Nbs1 display reduced homologous repair of the single double-strand break in chromosomally integrated substrate. PMID: 17082765
32. the defects observed in Nbs1(DeltaC/DeltaC) result from impaired phosphorylation of ATM targets PMID: 17429352
33. REVIEW of phosphorylation signaling cascade response to DNA damage.Phosphorylation of NBS1 is regulated by the acetylation status of the protein, which is modulated by SIRT1 deacetylase. PMID: 18156798
34. The (NBS1 [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci. PMID: 18411308
35. Accelerated DNA repair required both the NBS1 protein and Hdm2, accompanied by phosphorylation of Hdm2, dissociation of NBS-1 and Hdm2, inhibition of NBS-1 degradation, and accelerated phosphorylation of ATM. PMID: 18723444
36. Sequences in mouse nibrin required to direct the nuclear localization of the MRE11/RAD50/nibrin complex were identified by site-specific mutagenesis. PMID: 19075003
37. During V(D)J recombination, MRN deficiency leads to the aberrant joining of Rag double-strand breaks (DSBs) and to the accumulation of unrepaired coding ends. PMID: 19221393
38. the NBS1/ATR/BRCA1 repair machinery affects centrosome behavior, and this might be a crucial role in the prevention of malignances. PMID: 19244116
39. This study demonstrated that Nbs1 loss seriously hampered the organization of glial cells in the optic nerve as well as in the retina PMID: 19345213
40. NBS1 is required for alternative NHEJ of hairpin coding ends, suppresses alternative NHEJ of signal ends, and promotes proper resolution of inversional recombination intermediates. PMID: 19362533
41. Results suggest a model in which MRN stabilizes distant breaks and processes DNA termini to facilitate repair by both the classical and alternative NHEJ pathways. PMID: 19633670
42. The role of Mre11/Rad50/Nbs1 at dysfunctional telomeres is multifaceted, involving both repression of NHEJ in G(2) through end resection and induction of NHEJ in G(1) through ATM-dependent signaling. PMID: 19667071

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KEGG: mmu:27354

STRING: 10090.ENSMUSP00000029879

UniGene: Mm.20866